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Adhesion-GPCRs pp 157–166Cite as

Signal Transduction Mediated through Adhesion-GPCRs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

The signaling cascade of most adhesion-GPCRs remains uncharacterized, as the majority are still orphan receptors and further complicated by their unique structure containing a cleaved long extracellular domain (ECD) and a seven-transmembrane domain (7TM). In this chapter, we review previous reports which suggest G protein-dependent and -independent signaling pathways of adhesion-GPCRs and present our approach to investigate the signal transduction of the adhesion-GPCR, GPR56.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, 630-0192, Japan

    Hiroshi Itoh

Authors
  1. Norikazu Mizuno
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  2. Hiroshi Itoh
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Editor information

Editors and Affiliations

  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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Mizuno, N., Itoh, H. (2010). Signal Transduction Mediated through Adhesion-GPCRs. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_14

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