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The Role of CD97 in Regulating Adaptive T-Cell Responses

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Book cover Adhesion-GPCRs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

CD97 was identified as an early activation marker on T cells, having low expression on naive T cells. This is a common feature of molecules that have a role in T-cell function. It was subsequently identified as a ligand for CD55, which has been previously identified as an innate regulator of complement. The interaction of this receptor-ligand pair has been shown to provide a potent costimulatory signal to human T cells, despite their modest affinity. Though both CD97 and CD55 are expressed on T cells as well as antigen presenting cells (APCs), their interaction is significant when CD97 on APCs interacts with CD55 on T cells. The converse interaction is poorly defined and may be less significant. A unique aspect of the interaction of CD97 with CD55 is the stimulation of naive T cells, leading to the induction of IL-10 producing cells that behave like Tr1 regulatory cells. This raises a number of questions regarding the dual functions of CD55; regulating complement and stimulating T cells via CD97 interaction and any potential overlap in the consequences of these dual roles.

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Author information

Authors and Affiliations

  1. Academic Clinical Oncology, The City Hospital, The University of Nottingham, Hucknall Road, Nottingham, Ng5 1PB, UK

    Ian Spendlove

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  1. Ian Spendlove
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  2. Ruhcha Sutavani
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Editor information

Editors and Affiliations

  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Spendlove, I., Sutavani, R. (2010). The Role of CD97 in Regulating Adaptive T-Cell Responses. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_12

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