Adhesion-GPCRs pp 121-127 | Cite as

Immunity and Adhesion-GPCRs

  • Simon Yona
  • Hsi-Hsien Lin
  • Martin Stacey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 706)


Adhesion-GPCRs are unusual, owing to their unique structure, comprising a large and complex extracellular domain composed of various common protein modules. Adhesion-GPCR family members are expressed ubiquitously; however the expression of each receptor is highly regulated and often restricted to specific cell types. The EGF-TM7 adhesion-GPCR subfamily members are predominantly expressed by leukocytes and involved in coordinating both the innate and acquired immune responses. Here we highlight some immunological insights in relation to EGF-TM7 proteins and other members of the adhesion-GPCR family.


Chondroitin Sulphate Acquire Immune Response Epidermal Growth Factor Domain Rheumatoid Synovial Tissue Human Neutrophil Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Simon Yona
  • Hsi-Hsien Lin
  • Martin Stacey
    • 1
  1. 1.Department of ImmunologyLeeds UniversityLeedsUK

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