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The Molecular Immunology of Complex Carbohydrates-3 pp 757–767Cite as

Glycan Arrays to Decipher the Specificity of Plant Lectins

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 705))

Abstract

In recent years, evidence has been accumulating that protein–carbohydrate interactions play an important role in host–pathogen interaction(s), development, cell–cell communication, and cell signaling. To study the protein–carbohydrate recognition phenomena that take place within or at the surface of a cell, it is requisite to have the appropriate tools for dissecting this type of interaction. During the past decade, microarray technology has successfully been introduced into the field of glycobiology. These carbohydrate or glycan microarrays allow the rapid and comprehensive screening of carbohydrate-binding proteins for interaction with a large set of carbohydrate structures and characterization of their carbohydrate-binding properties.

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Acknowledgments

The financial support of the Research Council of Ghent University and the Fund for Scientific Research-Flanders (FWO grants G.0201.04 and G.0022.08) is gratefully acknowledged. This work was supported in part by the Consortium for Functional Glycomics under National Institutes of Health/National Institute of General Medical Sciences Grant GM62116.

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Authors and Affiliations

  1. Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000, Gent, Belgium

    Els J. M. Van Damme

Authors
  1. Els J. M. Van Damme
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  2. David F. Smith
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  3. Richard Cummings
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  4. Willy J. Peumans
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Corresponding author

Correspondence to Els J. M. Van Damme .

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Editors and Affiliations

  1. College of Medicine, Institute of Molecular&Cellular Biology, Chang-Gung University, Kwei-San, Tao-Yuan, 333, Taiwan R.O.C.

    Albert M. Wu

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Van Damme, E.J.M., Smith, D.F., Cummings, R., Peumans, W.J. (2011). Glycan Arrays to Decipher the Specificity of Plant Lectins. In: Wu, A. (eds) The Molecular Immunology of Complex Carbohydrates-3. Advances in Experimental Medicine and Biology, vol 705. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7877-6_39

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