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Characterization of Protein Therapeutics using Mass Spectrometry pp 305–341Cite as

Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

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Abstract

As some of the most essential molecules of life, proteins fulfill a plethora of biochemical functions within every living organism. They are involved in virtually all cell functions, such as cell division, cell death, immune response, signal transduction, and ligand binding. In contrast to small molecules, proteins are significantly more complicated in structure. In biophysical conditions, proteins fold into unique three-dimensional structures in solution that are flexible and dynamic.

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Authors and Affiliations

  1. Bristol-Myers Squibb, Route 206 and Province Line Road, Princeton, NJ, 08543, USA

    Hui Wei, Adrienne A. Tymiak & Guodong Chen

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  1. Hui Wei
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  2. Adrienne A. Tymiak
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    Guodong Chen

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Wei, H., Tymiak, A.A., Chen, G. (2013). Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization. In: Chen, G. (eds) Characterization of Protein Therapeutics using Mass Spectrometry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7862-2_8

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