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Biophysical Regulation of Vascular Differentiation and Assembly pp 167–202Cite as

Microenvironmental Regulation of Tumor Angiogenesis: Biological and Engineering Considerations

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Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Tumor angiogenesis is fundamental to tumor growth and metastasis, and antiangiogenic therapies have been developed to target this process. However, the clinical success of these treatments has been limited, which may be due, in part, to an incomplete understanding of cell–microenvironment interactions and their role in tumor angiogenesis. Traditionally, two-dimensional (2D) culture approaches have been used to study tumor progression in vitro, but these systems fail to faithfully recreate tumor microenvironmental conditions contributing to tumor angiogenesis in vivo. By integrating cancer biology with tissue engineering and drug delivery approaches, the development of biologically inspired tumor models has emerged. Such 3D model systems allow studying the specific role of soluble factor signaling, cell–extracellular matrix (ECM) interactions, cell–cell interactions, mechanical cues, and metabolic stress. This chapter discusses specific biological and engineering design considerations for tissue-engineered tumor models and highlights their application for defining the underpinnings of tumor angiogenesis.

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Acknowledgments

The authors thank Emily Brooks and Daniel Brooks from Cornell University for their help with the editing of this chapter and acknowledge funding from the Cornell Nanobiotechnology Center (supported by the STC Program of the National Science Foundation under Agreement No. ECS-9876771), the Morgan Fund for Tissue Engineering, NIH (RC1 CA146065, 1U54 CA143876-01), and NSF (graduate research fellowship for SPP).

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  1. Department of Biomedical Engineering, Cornell University, 157 Weill Hall, Ithaca, NY, 14853, USA

    Claudia Fischbach

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  1. David W. Infanger
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  2. Siddharth P. Pathi
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    Sharon Gerecht

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Infanger, D.W., Pathi, S.P., Fischbach, C. (2011). Microenvironmental Regulation of Tumor Angiogenesis: Biological and Engineering Considerations. In: Gerecht, S. (eds) Biophysical Regulation of Vascular Differentiation and Assembly. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7835-6_8

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