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Genetics of Childhood and Adolescent Anxiety

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Handbook of Child and Adolescent Anxiety Disorders

Abstract

There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. However, the genetic etiology of anxiety disorder is complex (Elston, 2000), involving the interaction of multiple genes of small or modest effect and gene–environment interactions. For such complex traits, genetic risk factors are probabilistic rather than deterministic in nature (Page, George, Go, Page, & Allison, 2003). In addition to genetic complexity, the marked phenotypic heterogeneity of anxiety poses a challenge to genetic investigators, since it is highly unlikely that our current diagnostic categories “carve nature at its joints” with regard to the underlying genetic architecture. Despite these challenges, significant advances in our understanding of the genetic basis of anxiety have been made in recent years. This chapter attempts to provide a critical review of current knowledge regarding the genetic determinants of anxiety.

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Authors and Affiliations

  1. Department of Psychiatry, Hospital for Sick Children & University of Toronto, Toronto, ON, Canada

    Paul D. Arnold

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  1. Paul D. Arnold
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  2. Stephanie Taillefer
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Correspondence to Paul D. Arnold .

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  1. , Department of Psychology, Fordham University, East Fordham Road 441, Bronx, 10458, New York, USA

    Dean McKay

  2. , Departments of Pediatrics, Psychiatry, a, University of South Florida, Tampa, 33612, Florida, USA

    Eric A. Storch

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Arnold, P.D., Taillefer, S. (2011). Genetics of Childhood and Adolescent Anxiety. In: McKay, D., Storch, E. (eds) Handbook of Child and Adolescent Anxiety Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7784-7_5

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