Homostability

Abstract

Genetic information is ‘written’ by a variation in sequence on the one hand, and the physical stability of the double-stranded structure is determined by the base composition on the other hand. … DNA is found to consist of a number of homostability regions which come from homogenous base sequences consisting of 500 base pairs or more. … Biologically, it is hard … to believe that such regional homostability originates in a fundamental characteristic of the genetic code itself. It is quite plausible … that the homostability region plays an important part somewhere in the biological process within which the DNA is closely related. If so, then the evolutionary selective force can be considered to have fixed such regions of DNA. From the size of the homostability region, recombination might be one possible process which is aided by it. In any case, the wobble bases [in codons] must give the necessary redundancy to make a homostability region without spoiling the biological meaning of the genetic code.