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Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer

  • Krishna K. Sanapala
  • Kapila Hewaparakrama
  • Kyung A. Kang
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)

Abstract

Magnetic nanoparticle mediated low heat hyperthermia (42~45 o C) via alternating electromagnetic (AEM) energy is a promising, cancer specific and minimally-invasive cancer therapy. Iron oxide particles frequently used for this therapy are non-toxic and already used as a contrast agent for magnetic resonance imaging. One important issue in the hyperthermia is applying an appropriate amount of energy to the tumor at various sizes and depths, with a minimal damage to normal tissue. For the therapy to be desirable, the AEM energy applicator needs to be non-invasive and user-friendly. To better understand the effect of the probe on the magnetic field distribution, computer simulation was performed for the field distribution by probes with various configurations. In a solenoid-type probe, the field is mainly inside the probe and, therefore, is difficult to use on body. A pancake-shaped probe is easy to use but the field penetration is shallow and, thus, may better serve surface tumor treatment. A sandwich probe, composed of two pancake probes, has a penetration depth deeper than a pancake probe. The results also showed that the spacing between two adjacent coils and the number of coil turns are very important for controlling the field penetration depth and strength. Experiments were also performed to study the effects of the size and concentration of iron oxide nanoparticles on heating. Among the tested particle sizes of 10~50 nm, 30 nm particles showed the best heating for the same mass.

Keywords

Penetration Depth Thermal Ablation Iron Oxide Particle Coil Turn Radiofrequency Thermal Ablation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    FalkMH and Issels RD (2001), Hyperthermia in oncology, International Journal of Hyperthermia, 17, 1-18Google Scholar
  2. 2.
    Livraghi T, Lazzaroni S, and Meloni F (2001) Radiofrequency thermal ablation of hepatocellular carcinoma, European Journal of Ultrasound, 13, 159-166PubMedCrossRefGoogle Scholar
  3. 3.
    Scoggins CR, Gleason JF, Martin RC, Kehdy FJ, Hutchinson JR, and McMasters KM (2004) Thermal ablation of liver tumors, Cancer Therapy, 2, 455-462Google Scholar
  4. 4.
    Kalambur VS, Han B, Hammer BE, Shield TW, Bischof JC (2005) In vitro characterization of movement, heating and visualization of magnetic nanoparticles for biomedical applications, Nanotechnology, 16, 1221–1233CrossRefGoogle Scholar
  5. 5.
    Kotitz, R, Weitschies W, Trahms L, Semmler W (1999) Investigation of brownian and neel relaxation in magnetic fluids, Journal of Magnetism and Magnetic Materials, 201, 102-104CrossRefGoogle Scholar
  6. 6.
    Jin H, Kang KA. (2007) Application of novel metal nanoparticles as optical/thermal agents in optical mammography and hyperthermic treatment for breast cancer, advances in experimental medicine and biology, 599, Oxygen Transport to Tissue XXVIII, 45-52CrossRefGoogle Scholar
  7. 7.
    Jin H, Hong B, Kakar SS, Kang KA (2008) Tumor-specific nano-entities for optical detection and hyperthermic treatment of breast cancer, Advances in ExperimentalMedicine and Biology, 614 (31), Oxygen Transport to Tissue XXIX, 275-284CrossRefGoogle Scholar
  8. 8.
    Smythe, WR (1950) Static and dynamic electricity, McGraw Hill publishers, New YorkGoogle Scholar
  9. 9.
    Hergt R, Andra W, D’ambly CG, Hilger I, KaiserWA, Richter Uwe, Schmidt HG (1998)Physical limits of hyperthermia using magnetite fine particles, IEEE Transactions on Magnetics, 34(5), 3745-3754CrossRefGoogle Scholar
  10. 10.
    Mornet S, Vasseur S, Grasset F, Veverka P, Goglio G, Demourgues A, Portier J, Pollert E, Duguet E (2004) Magnetic nano particle design for medical diagnosis and therapy, Journal of Materials Chemistry, 14, 2161–2175CrossRefGoogle Scholar
  11. 11.
    Zhang SL, Li J, Lykotrafitis G, Bao G, Suresh S (2008) Size-dependant endocytosis of nanoparticles, Advanced Materials, 20, 1-6CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Krishna K. Sanapala
    • 1
  • Kapila Hewaparakrama
    • 1
  • Kyung A. Kang
    • 1
  1. 1.Department of Chemical EngineeringUniversity of LouisvilleLouisvilleUSA

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