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Genomics of Foodborne Bacterial Pathogens pp 311–341Cite as

Genomic and Transcriptomic Analyses of Foodborne Bacterial Pathogens

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Part of the book series: Food Microbiology and Food Safety ((FMFS))

Abstract

DNA microarrays (often interchangeably called DNA chips or DNA arrays) are among the most popular analytical tools for high-throughput comparative genomic and transcriptomic analyses of foodborne bacterial pathogens. A typical DNA microarray contains hundreds to millions of small DNA probes that are chemically attached (or “printed”) onto the surface of a microscopic glass slide. Depending on the specific “printing” and probe synthesis technologies for different microarray platforms, such DNA probes can be PCR amplicons or in situ synthesized short oligonucleotides. DNA microarray technologies have revolutionized the way that we investigate the biology of foodborne bacterial pathogens. The major advantage of these technologies is that DNA microarrays allow comparison of subtle genomic or transcriptomic variations between two bacterial samples, such as genomic variations between two different bacterial strains or transcriptomic alterations of same bacterial strain under two different treatments. Some applications of comparative genomic hybridization microarrays and global gene expression microarrays have been covered in previous chapters of this book.

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Authors and Affiliations

  1. National Center for Food Safety and Technology, Illinois Institute of Technology, Summit, IL, 60501, USA

    Wei Zhang

  2. Department of Food Science, Pennsylvania State University, University Park, PA, USA

    Edward G. Dudley

  3. New York State Department of Health, Wadsworth Center, Albany, NY, USA

    Joseph T. Wade

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  1. Wei Zhang
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  2. Edward G. Dudley
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Correspondence to Wei Zhang .

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Editors and Affiliations

  1. Dept. Food Science, Cornell University, Stocking Hall 116, Ithaca, 14853, New York, USA

    Martin Wiedmann

  2. National Center for Food Safety &, Technology, Illinois Institute of Technology, S. Archer Rd. 6502, Summit, 60501, Illinois, USA

    Wei Zhang

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Zhang, W., Dudley, E.G., Wade, J.T. (2011). Genomic and Transcriptomic Analyses of Foodborne Bacterial Pathogens. In: Wiedmann, M., Zhang, W. (eds) Genomics of Foodborne Bacterial Pathogens. Food Microbiology and Food Safety. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7686-4_10

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