Neurological Complications of Plasma Cell Disorders

  • Jan Drappatz
  • Kurt A. Jaeckle


Plasma cell disorders include monoclonal gammopathies of unknown significance, multiple myeloma, plasmacytoma, Waldenstrom’s macroglobulinemia, and amyloidosis. This group of neoplastic diseases involves proliferation of a single clone of plasma cells, producing a monoclonal immunoglobulin protein or immunoglobulin fragment (M protein) that can be identified as a spike on electrophoresis of serum or urine. Plasma cell disorders are associated with a wide spectrum of neurological complications. The pathophysiology, diagnosis, and management of these neurological complications are the subject of this review.


Multiple Myeloma Peripheral Neuropathy Nephrogenic Diabetes Insipidus Chronic Inflammatory Demyelinating Polyradiculoneuropathy Sensorimotor Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of NeurologyHarvard Medical School, Center for Neuro-Oncology, Dana Farber Cancer Institute, Brigham and Women’s HospitalBostonUSA
  2. 2.Departments of Oncology and NeurologyMayo Clinic JacksonvilleJacksonvilleUSA

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