After hematopoietic stem cell transplant (HSCT), up to 60% of patients develop pulmonary complications. In spite of antibacterial, antiviral, and antifungal prophylaxis, reduced host defenses render the HSCT patient vulnerable to pulmonary and other infections in the early weeks and even months post-transplantation. This chapter will suggest an integrative approach followed by a description of the most common pulmonary syndromes seen in HSCT patients, including diffuse alveolar hemorrhage (DAH), idiopathic pneumonia syndrome (IPS), bronchiolitis obliterans syndrome (BO or BOS), and cryptogenic organizing pneumonia (COP).
KeywordsHematopoietic Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplant Airflow Obstruction Ground Glass Opacity Bronchiolitis Obliterans Syndrome
- Clark, J., Hansen, J., Hertz, M., Parkman, R., Jensen, L., Peavy, H. (1993). NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Resp Diseases, 147:1601–1606.Google Scholar
- Fukuda, T., Hackman, R. G., Sandmaier, B., Boeckh, M., Maris, M., Maloney, D., et al. (2003). Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplanation. Blood, 102:2777–2785.CrossRefPubMedGoogle Scholar
- Vasu, ST., Cavalazzi, R., Hirani, A., Kane, K, (2009) Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. Resp Care, 1028–1032.Google Scholar