Pulmonary Complications

  • Tarek Eid
  • Alan F. Barker
Chapter

Abstract

After hematopoietic stem cell transplant (HSCT), up to 60% of patients develop pulmonary complications. In spite of antibacterial, antiviral, and antifungal prophylaxis, reduced host defenses render the HSCT patient vulnerable to pulmonary and other infections in the early weeks and even months post-transplantation. This chapter will suggest an integrative approach followed by a description of the most common pulmonary syndromes seen in HSCT patients, including diffuse alveolar hemorrhage (DAH), idiopathic pneumonia syndrome (IPS), bronchiolitis obliterans syndrome (BO or BOS), and cryptogenic organizing pneumonia (COP).

Keywords

Pneumonia Influenza Cocaine Fentanyl Aspergillus 

References

  1. Bekele, A., Ayalew, T., Mark, R., Michael, J., Mark, E., Steve, G. (2002). Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med, 166:641–645.CrossRefGoogle Scholar
  2. Clark, J., Hansen, J., Hertz, M., Parkman, R., Jensen, L., Peavy, H. (1993). NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Resp Diseases, 147:1601–1606.Google Scholar
  3. Fukuda, T., Hackman, R. G., Sandmaier, B., Boeckh, M., Maris, M., Maloney, D., et al. (2003). Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplanation. Blood, 102:2777–2785.CrossRefPubMedGoogle Scholar
  4. Gupta, S., Jain, A., Warneke, C., Gupta, A., Shannon, V., Morice, R., et al. (2007). Outcome of alveolar hemorrhage in hematopoietic stem cell transplant recipients. Bone Marrow Transplant, 40:71–78.CrossRefPubMedGoogle Scholar
  5. Kotloff, R., Ahya, V., Crawford, S. (2004). Pulmonary complications of solid organ and stem cell transplantation. Am J Resp Crit Care Med, 170:22–48.CrossRefPubMedGoogle Scholar
  6. Silva, C, Muller, N. (2009). Idiopathic interstitial pneumonias. J Thorac Imaging, 24:260–273.CrossRefPubMedGoogle Scholar
  7. Soubani, A., Uberti, J. (2007). Bronchiolitis obliterans following hematopoietic stem cell transplantation. Eur Respir J, 29:1007–1019.CrossRefPubMedGoogle Scholar
  8. Vasu, ST., Cavalazzi, R., Hirani, A., Kane, K, (2009) Clinical and radiologic distinctions between secondary bronchiolitis obliterans organizing pneumonia and cryptogenic organizing pneumonia. Resp Care, 1028–1032.Google Scholar
  9. Williams, K., Chien, J. G., Pavletic, S. (2009). Bronchiolitis obliterans after allogenetic hematopoietic stem cell transplantation. JAMA, 302:306–314.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Tarek Eid
    • 1
  • Alan F. Barker
    • 1
  1. 1.Pulmonary and Critical Care Medicine, Oregon Health and Science UniversityPortlandUSA

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