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Overview of Hematopoietic Stem Cell Transplantation

  • Richard T. Maziarz
Chapter

Abstract

Hematopoietic stem cell transplantation (HSCT) has evolved over the past 50–60 years to become the standard of care procedure for many disorders. Advances in immunogenetics and immunobiology, conditioning regimens, disease characterization and risk stratification, immune suppression, antimicrobials, and other types of supportive care have made this expansion possible. Some of the earliest work contributed to the first successful bone marrow transplant, performed in a young child with immune deficiency syndrome in 1968. Approximately 15 years later, the graft-versus-leukemia response was recognized as overlapping with the development of graft-versus-host disease (GvHD). In the early 1980s, bone marrow transplantation was no longer considered experimental, but as the standard of care for a variety of disorders including acute leukemia and aplastic anemia.

Keywords

Chronic Myeloid Leukemia Hematopoietic Stem Cell Transplantation Aplastic Anemia Conditioning Regimen Hematopoietic Stem Cell Transplantation Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Deeg, H., DiPersio, J., Young, J., Maziarz, R., Perreault, C., Margolis, D., et al. (2009). ASBMT policy statement 2009 research priorities. Biol Blood Marrow Transplant, 15:1489–1491.CrossRefGoogle Scholar
  2. Gajewski, J., LeMaistre, F., Silver, S., Lill, M., Selby, G., Horowitz, M., et al. (2009). Impending challenges in the hematopoietic stem cell transplantation physician workforce. Biol Blood Marrow Transplant, 15:1493–1501.CrossRefPubMedGoogle Scholar
  3. Giralt, S., Arora, M., Goldman, J., Lee, S., Maziarz, R., McCarthy, P., et al. (2007). Impact of imatinib therapy on the use of allogeneic haematopoietic progenitor cell transplantation for the treatment of chronic myeloid leukaemia. Br J Haematol, 137:461–467.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Richard T. Maziarz
    • 1
  1. 1.Center for Hematologic Malignancies, Adult Blood and Marrow Stem Cell Transplant Program, Oregon Health and Science UniversityPortlandUSA

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