Abstract
Choriocarcinoma is a rare tumor with an incidence of one in 25,000–40,000 pregnancies. It may develop after an abortion, a term or preterm pregnancy, an ectopic pregnancy, or a hydatidiform mole. In their oft-depicted diagram (Fig. 24.1), Hertig and Mansell estimated that the lesion was preceded by a complete hydatidiform mole in 50%, an abortion in 25%, a normal pregnancy in 22.5%, and an ectopic pregnancy in 2.5%. Choriocarcinoma is more common in young women and in those 40 years of age or older. There is as wide a geographic variation in its incidence as there is for hydatidiform moles.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Selected References
PHP5, Chapter 23, pages 837–846, 852–862.
Baergen RN. Gestational choriocarcinoma. Gen Diagn Pathol 1997;143:127–142.
Baergen RN, Rutgers JL. Trophoblastic lesions of the placental site. Gen Diagn Pathol 1997; 143:143–158.
Driscoll SG. Choriocarcinoma: an “incidental finding” within a term placenta. Obstet Gynecol 1963;21:96–101.
Gardiner HAR, Lage JM. Choriocarcinoma following a partial hydatidiform mole: a case report. Hum Pathol 1992;23:468–471.
Hertiz AT, Mansell H. Tumors of the female sex orangs Part I. Hydatidiform mole and choriocarcinoma. In, Atlas of Tumor Pathology. Sect IX. Fasc. 33. Armed Forces of Pathology, Washington, D.C., 1956.
Jacques SM, Qureshi F, Doss BJ, et al. Intraplacental choriocarcinoma associated with viable pregnancy: pathologic features and implications for the mother and infant. Pediatr Dev Pathol 1998;1:380–387.
Kendall A, Gillmore R, Newlands E. Chemotherapy for trophoblastic disease: current standards. Curr Opin Obstet Gynecol 2002;14:33–38.
Kohorn EI. The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and critical assessment. Int J Gynecol Cancer 2001;11:73–77.
Lage JM, Roberts DJ. Choriocarcinoma in a term placenta: pathologic diagnosis of tumor in an asymptomatic patient with metastatic disease. Int J Gynecol Pathol 1993;12:80–85.
Scully RE, Bonfiglio TA, Kurman RJ, et al. Histologic typing of female genital tract tumours, 2nd ed. New York: Springer-Verlag, 1994.
Seckl MJ, Newlands ES. Treatment of gestational trophoblastic disease. Gen Diagn Pathol 1997;143:159–171.
Silverberg SG, Kurman RJ. Tumors of the uterine corpus and gestational trophoblastic disease. Atlas of tumor pathology, Third Series, Fascicle 3. Washington, DC: AFIP, 1992.
Wells M. The pathology of gestational trophoblastic disease: recent advances. Pathology 2007;39:88–96.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Baergen, R.N. (2011). Choriocarcinoma. In: Manual of Pathology of the Human Placenta. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7494-5_24
Download citation
DOI: https://doi.org/10.1007/978-1-4419-7494-5_24
Published:
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-7493-8
Online ISBN: 978-1-4419-7494-5
eBook Packages: MedicineMedicine (R0)