Human

Chapter

Abstract

may contain the following mycotoxins and/or their metabolites:

Ochratoxin A

incidence: 4/22, sa. const.: people of Germany, contamination: natural, conc. range: <0.06–0.13 ng/ml, Ø conc.: 0.11 ng/ml, country: Germany

References

  1. 1.
    Abdulrazzaq, Y.M., Osman, N., Yousif, Z.M., Al-Falahi, S., 2003: Aflatoxin M1 in breast-milk of UAE women. Annals of Tropical Paediatrics 23, 173–179Google Scholar
  2. 2.
    Amra, H.A., 1998: Survey of aflatoxin M1 in Egyptian raw milk by enzyme-linked immuno­sorbent assay. Revue de Médicine Vétérinaire 149, 695Google Scholar
  3. 3.
    Amla, I., Kumari, S., Sreenivasa Murthy, V., Jayaraj, P., Parpia, H.A.P., 1970: Role of aflatoxin in Indian childhood cirrhosis. Indian Pediatrics 7, 262–270Google Scholar
  4. 4.
    Phillips, D.L., Yourtee, D.M., Searles, S., 1976: Presence of aflatoxin B1 in human liver in the United States. Toxicology and Applied Pharmacology 36, 403–406Google Scholar
  5. 5.
    Turner, P.C., Mendy, M., Whittle, H., Fortuin, M, Hall, A.J., Wild, C.P., 2000: Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Tropical Medicine and International Health 5, 837–841Google Scholar
  6. 6.
    Cova, L., Wild, C.P., Mehrotra, R., Turusov, V., Shirai, T., Lambert, V., Jacquet, C., Tomatis, L., Trépo, C., Montesano, R., 1990: Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Research 50, 2156–2163Google Scholar
  7. 7.
    Campbell, T.C., Chen, J., Liu, C., Parpia, B., 1990: Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People’s Republic of China. Cancer Research 50, 6882–6893Google Scholar
  8. 8.
    Chaves-Carballo, E., Ellefson, R.D., Gomez, M.R., 1976: An aflatoxin in the liver of a patient with Reye-Johnson Syndrome. Mayo Clinic Proceedings 51, 48–50Google Scholar
  9. 9.
    Bukovjan, K., Prošek, J., Bukovjanová, E., 1990: Preliminary results of the aflatoxin B1 content in liver tissue in the hare (Lepus europaeus). Československá Hygiena 35, 13–18 [Czech]Google Scholar
  10. 10.
    Shank, R.C., Bourgeois, C.H., Keschamras, N., Chandavimol, P., 1971: Aflatoxins in autopsy specimens from Thai children with an acute disease of unknown aetiology. Food and Cosmetics Toxicology 9, 501–507Google Scholar
  11. 11.
    Hendrickse, R.G., 1984: The influence of aflatoxins on child health in the tropics with particular reference to kwashiorkor. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 427–435Google Scholar
  12. 12.
    Qian, G.-S., Ross, R.K., Yu, M.C., Yuan, J.-M., Gao, Y.-T., Henderson, B.E., Wogan, G.N., Groopman, J.D., 1994: A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiology, Biomarkers & Prevention 3, 3–10Google Scholar
  13. 13.
    Wild, C.P., Yin, F., Turner, P.C., Chemin, I., Chapot, B., Mendy, M., Whittle, H., Kirk, G.D., Hall, A.J., 2000: Environmental and genetic determinants of aflatoxin-albumin adducts in The Gambia. International Journal of Cancer 86, 1–7Google Scholar
  14. 14.
    Yu, M.-W., Chiang, Y.-C., Lien, J.-P., Chen, C.-J., 1997: Plasma antioxidant vitamins, chronic hepatitis B virus infection and urinary aflatoxin B1-DNA adducts in healthy males. Carcinogenesis 18, 1189–1194Google Scholar
  15. 15.
    Wild, C.P., Jiang, Y.-Z., Allen, S.J., Jansen, L.A.M., Hall, A.J., Montesano, R., 1990: Aflatoxin-albumin adducts in human sera from different regions of the world. Carcinogenesis 11, 2271–2274Google Scholar
  16. 16.
    Kirby, G.M., Chemin, I., Montesano, R., Chisari, F.V., Lang, M.A., Wild, C.P., 1994: Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice. Molecular Carcinogenesis 11, 74–80Google Scholar
  17. 17.
    Diallo, M.S., Syila, A., Sidibé, K., Sylla, B.S., Trepo, C.R., Wild, C.P., 1995: Prevalence of exposure to aflatoxin and hepatitis B and C virus in Guinea, West Africa. Natural Toxins 3, 6–9Google Scholar
  18. 18.
    Autrup, H., Bradley, K.A., Shamsuddin, A.K.M., Wakhisi, J., Wasunna, A., 1983: Detection of putative adduct with fluorescence characteristics identical to 2,3-dihydro-2-(7′-guanyl)-3-hydroxyaflatoxin B1 in human urine collected in Murang’a district, Kenya. Carcinogenesis 4, 1193–1195Google Scholar
  19. 19.
    Siray, M.Y., Hayes, A.W., Unger, P.D., Hogan, G.R., Ryan, N.J., Wray, B.B., 1981: Analysis of aflatoxin B1 in human tissues with high-pressure liquid chromatography. Toxicology and Applied Pharmacology 58, 422–430Google Scholar
  20. 20.
    Wray, B.B., Hayes, A.W., 1980: Aflatoxin B1 in the serum of a patient with primary hepatic carcinoma. Environmental Research 22, 400–403Google Scholar
  21. 21.
    Tsuboi, S., Nakagawa, T., Tomita, M., Seo, T., Ono, H., Kawamura, K., Iwamura, N., 1984: Detection of aflatoxin B1 in serum samples of male Japanese subjects by radioimmunoassay and high-performance liquid chromatography. Cancer Research 44, 1231–1234Google Scholar
  22. 22.
    Wang, J.-S., Qian, G.-S., Zarba, A., He, X., Zhu, Y.-R., Zhang, B.-C., Jacobson, L., Gange, S.J., Muñoz, A., Kensler, T.W., Groopman, J.D., 1996: Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People’s Republic of China. Cancer Epidemiology, Biomarkers & Prevention 5, 253–261Google Scholar
  23. 23.
    Wild, C.P., Fortuin, M., Donato, F., Whittle, H.C., Hall, A.J., Wolf, C.R., Montesano, R., 1993: Aflatoxin, liver enzymes, and hepatitis B virus infection in Gambian children. Cancer Epidemiology, Biomarkers & Prevention 2, 555–561Google Scholar
  24. 24.
    Wild, C.P., Hasegawa, R., Barraud, L., Chutimataewin, S., Chapot, B., Ito, N., Montesano, R., 1996: Aflatoxin-albumin adducts: a basis for comparative carcinogenesis between animals and humans. Cancer Epidemiology, Biomarkers & Prevention 5, 179–189Google Scholar
  25. 25.
    Groopman, J.D., Jiaqi, Z., Donahue, P.R., Pikul, A., Lisheng, Z, Jun-shi, C., Wogan, G.N., 1992: Molecular dosimetry of urinary aflatoxin-DNA-adducts in people living in Guangxi Autonomous Region, People’s Republic of China. Cancer Research 52, 45–52Google Scholar
  26. 26.
    Sheabar, F.Z., Groopman, J.D., Qian, G.-S., Wogan, G.N., 1993: Quantitative analysis of aflatoxin – albumin adducts. Carcinogenesis 14, 1203–1208Google Scholar
  27. 27.
    Wild, C.P., Garner, R.C., Montesano, R., Tursi, F., 1986: Aflatoxin B1 binding to plasma albumin and liver DNA upon chronic administration to rats. Carcinogenesis 7, 853–858Google Scholar
  28. 28.
    Stora, C., Dvorackova, I., Ayraud, N., 1981: Characterization of aflatoxin B1 (AFB) in human liver cancer. Research Communications in Chemical Pathology and Pharmacology 31, 77–85Google Scholar
  29. 29.
    Hollstein, M.C., Wild, C.P., Bleicher, F., Chutimataewin, S., Harris, C.C., Srivanakul, P., Montesano, R., 1993: p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand. International Journal of Cancer 53, 51–55Google Scholar
  30. 30.
    Wild, C.P., Jansen, L.A.M., Cova, L., Montesano, R., 1993: Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus. Environmental Health Perspectives 99, 115–122Google Scholar
  31. 31.
    Cova, L., Mehrotra, R., Wild, C.P., Chutimataewin, S., Cao, S.F., Duflot, A., Prave, M., Yu, S.Z., Montesano, R., Trepo, C., 1994: Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks. British Journal of Cancer 69, 104–109Google Scholar
  32. 32.
    Coulter, J.B.S., Suliman, G.I., Lamplugh, S.M., Mukhtar, B.I., Hendrickse, R.G., 1986: Aflatoxins in liver biopsies from Sudanese children. American Journal of Tropical Medicine and Hygiene 35, 360–365Google Scholar
  33. 33.
    Allen, S.J., Wild, C.P., Wheeler, J.G., Riley, E.M., Montesano, R., Bennett, S., Whittle, H.C., Hall, A.J., Greenwood, B.M., 1992: Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 426–430Google Scholar
  34. 34.
    Kensler, T.W., Egner, P.A., Trush, M.A., Bueding, E., Groopman, J.D., 1985: Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione. Carcinogenesis 6, 759–763Google Scholar
  35. 35.
    Becroft, D.M., Webster, D.R., 1972: Aflatoxins and Reye’s disease. British Medical Journal 4, 117Google Scholar
  36. 36.
    Hendrickse, R.G., Coulter, J.B.S., Lamplugh, S.M., MacFarlane, S.B.J., Williams, T.E., Omer, M.I.A., Suliman, G.I., 1982: Aflatoxins and kwashiorkor: a study in Sudanese children. British Medical Journal 285, 843–846Google Scholar
  37. 37.
    Turner, P.C., Moore, S.E., Hall, A.J., Prentice, A.M., Wild, C.P., 2003: Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environmental Health Perspectives 111, 217–220Google Scholar
  38. 38.
    Nabney, J., Burbage, M.B., Allcroft, R., Lewis, G., 1967: Metabolism of aflatoxin in sheep: excretion pattern in the lactating ewe. Food and Cosmetics Toxicology 5, 11–17Google Scholar
  39. 39.
    Patterson, D.S.P., Glancy, E.M., Roberts, B.A., 1980: The “carry over” of aflatoxin M1 into the milk of cows fed rations containing a low concentration of aflatoxin B1. Food and Cosmetics Toxicology 18, 35–37Google Scholar
  40. 40.
    Allcroft, R., Roberts, B.A., Lloyd, M.K., 1968: Excretion of aflatoxin in a lactating cow. Food and Cosmetics Toxicology 6, 619–625Google Scholar
  41. 41.
    Zhu, J-Q., Zhang, L.-S., Hu, X., Xiao, Y., Chen, J.-S., Xu, Y.-C., Fremy, J., Chu, F.S., 1987: Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Research 47, 1848–1852Google Scholar
  42. 42.
    Croy, R.G., Wogan, G.N., 1981: Temporal patterns of covalent DNA adducts in rat liver after single and multiple doses of aflatoxin B1. Cancer Research 41, 197–203Google Scholar
  43. 43.
    Choudhary, P.L., Sharma, R.S., Borkhatriya, V.N., Murthi, T.N., Wadodkar, U.R., 1997: Survey on the levels of aflatoxin M1 in raw and market milk in and around Anand Town. Indian Journal of Dairy Science 50, 156–158Google Scholar
  44. 44.
    Domagala, J., Kisza, J., Blüthgen, A., Heeschen, W., 1997: Contamination of milk with aflatoxin M1 in Poland. Milchwissenschaft 52, 631–633Google Scholar
  45. 45.
    Dragacci, S., Fremy, J.-M., 1993: Occurrence of aflatoxin M1 in milk. Fifteen years of sanitary control. Sciences des Aliments 13, 711–722 [French]Google Scholar
  46. 46.
    El-Nezami, H.S., Nicoletti, G., Neal, G.E., Donohue, D.C., Ahokas, J.T., 1995: Aflatoxin M1 in human breast milk samples from Victoria, Australia and Thailand. Food and Cosmetics Toxicology 33, 173–179Google Scholar
  47. 47.
    Ferguson-Foos, J., Warren, J.D., 1984: Improved cleanup for liquid chromatographic analysis and fluorescence detection of aflatoxins M1 and M2 in fluid milk products. Journal of the Association of Official Analytical Chemists 67, 1111–1114Google Scholar
  48. 48.
    Wang, J.-S., Shen, X., He, X., Zhu, Y.-R., Zhang, B.-C., Wang, J.-B., Qian, G.-S., Kuang, S.-Y., Zarba, A., Egner, P.A., Jacobson, L.P., Muñoz, A., Helzlsouer, K.J., Groopman, J.D., Kensler, T.W., 1999: Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People’s Republic of China. Journal of the National Cancer Institute 91, 347–354Google Scholar
  49. 49.
    Hsieh, L.-L., Hsu, S.-W., Chen, D.-S., Santella, R.M., 1988: Immunological detection of aflatoxin B1-DNA adducts formed in vivo. Cancer Research 48, 6328–6331Google Scholar
  50. 50.
    Groopman, J.D., Hall, A.J., Whittle, H., Hudson, G.J., Wogan, G.N., Montesano, R., Wild, C.P., 1992: Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in The Gambia, West Africa. Cancer Epidemiology, Bio-markers & Prevention 1, 221–227Google Scholar
  51. 51.
    Nelson, D.B., Kimbrough, R., Landigran, P.S., Hayes, A.W., Yang, G.C., Benanides, J., Morens, D.M., Morse, D., Pollack, M., Powell, K.E., Sullivan-Bolyai, J.Z., 1980: Aflatoxins and Reye’s Syndrome: a case control study. Pediatrics 66, 865–869Google Scholar
  52. 52.
    Scholl, P.F., Musser, S.M., Groopman, J.D., 1997: Synthesis and characterization of aflatoxin B1 mercapturic acids and their identification in rat urine. Chemical Research in Toxicology 10, 1144–1151Google Scholar
  53. 53.
    Madden, U.A., Stahr, H.M., 1995: Retention and distribution of aflatoxin in tissues of chicks fed aflatoxin-contaminated poultry rations amended with soil. Veterinary and Human Toxicology 37, 24–29Google Scholar
  54. 54.
    Wilkinson, A.P., Denning, D.W., Morgan, R.A., 1988: Analysis of UK sera for aflatoxin by enzyme-linked immunosorbent assay. Human Toxicology 7, 353–356Google Scholar
  55. 55.
    Soini, Y., Chia, S.C., Bennett, W.P., Groopman, J.D., Wang, J.-S., de Benedetti, V.M.G., Cawley, H., Welsh, J.A., Hansen, C., Bergasa, N.V., Jones, E.A., di Bisceglie, A.M., Trivers, G.E., Sandoval, C.A., Calderon, I.E., Munoz Espinosa, L.E., Harris, C.C., 1996: An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis 17, 1007–1012Google Scholar
  56. 56.
    Denning, D.W., Allen, R., Wilkinson, A.P., Morgan, M.R.A., 1990: Transplacental transfer of aflatoxin in humans. Carcinogenesis 11, 1033–1035Google Scholar
  57. 57.
    Kensler, T.W., Gange, S.J., Egner, P.A., Dolan, P.M., Muñoz, A., Groopman, J.D., Rogers, A.E., Roebuck, B.D., 1997: Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer. Cancer Epidemiology, Biomarkers & Prevention 6, 603–610Google Scholar
  58. 58.
    Harrison, J.C., Carvajal, M., Garner, R.C., 1993: Does aflatoxin exposure in the United Kingdom constitute a cancer risk? Environmental Health Perspectives 99, 99–105Google Scholar
  59. 59.
    Groopman, J.D., Donahue, P.R., Zhu, J., Chen, J., Wogan, G.N., 1985: Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proceedings of the National Academy of Science USA 82, 6492–6496Google Scholar
  60. 60.
    Neff, G.L., Edds, G.T., 1981: Aflatoxins B1 and M1: tissue residues and feed withdrawal profiles in young growing pigs. Food and Cosmetics Toxicology 19, 739–742Google Scholar
  61. 61.
    Apeagyei, F., Lamplugh, S.M., Hendrickse, R.G., Affram, K., Lucas, S., 1986: Aflatoxins in the livers of children with kwashiorkor in Ghana. Tropical and Geographical Medicine 38, 273–276Google Scholar
  62. 62.
    Rogan, W.J., Yang, G.C., Kimborough, R.D., 1985: Aflatoxin and Reye’s Syndrome: a study of livers from deceased cases. Archives of Environmental Health 40, 91–95Google Scholar
  63. 63.
    Prelusky, D.B., Veira, D.M., Trenholm, H.L., Hartin, K.E., 1986: Excretion profiles of the mycotoxin deoxynivalenol, following oral and intravenous administration to sheep. Fundamental and Applied Toxicology 6, 356–363Google Scholar
  64. 64.
    Pollmann, D.S., Koch, B.A., Seitz, L.M., Mohr, H.E., Kennedy, G.A., 1985: Deoxynivalenol-contaminated wheat in swine diets. Journal of Animal Science 60, 239–247Google Scholar
  65. 65.
    Ryan, N.J., Hogan, G.R., Hayes, A.W., Unger, P.D., Siraj, M.V., 1979: Aflatoxin B1: its role in the etiology of Reye’s Syndrome. Pediatrics 64, 71–75Google Scholar
  66. 66.
    Lüthy, J., Zweifel, U., Schlatter, C.H., 1980: Metabolism and tissue distribution of [14C]aflatoxin B1 in pigs. Food and Cosmetics Toxicology 18, 253–256Google Scholar
  67. 67.
    Coulter, J.B.S., Hendrickse, R.G., Lamplugh, S.M., MacFarlane, S.B.J., Moody, J.B., Omer, M.I.A., Suliman, G.I., Williams, T.E., 1986: Aflatoxins and kwashiorkor: clinical studies in Sudanese children. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 945–951Google Scholar
  68. 68.
    Denning, D.W., Onwubalili, J.K., Wilkinson, A.P., Morgan, M.R.A., 1988: Measurement of aflatoxin in Nigerian sera by enzyme-linked immunosorbent assay. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 169–171Google Scholar
  69. 69.
    Onyemelukwe, G.C., Ogbadu, G., 1981: Aflatoxin levels in sera of healthy first time rural blood donors: preliminary report. Transactions of the Royal Society of Tropical Medicine and Hygiene 75, 780–782Google Scholar
  70. 70.
    Côté, L.-M., Beasley, V.R., Bratich, P.M., Swanson, S.P., Shivaprasad, H.L., Buck, W.B., 1985: Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. Journal of Animal Science 61, 942–950Google Scholar
  71. 71.
    Helferich, W.G., Garrett, W.N., Hsieh, D.P.H., Baldwin, R.L., 1986: Feedlot performance and tissue residues of cattle consuming diets containing aflatoxins. Journal of Animal Science 62, 691–696Google Scholar
  72. 72.
    Cook, W.O., Richard, J.L., Osweiler, G.D., Trampel, D.W., 1986: Clinical and pathologic changes in acute bovine aflatoxicosis: rumen motility and tissue and fluid concentrations of aflatoxins B1 and M1. American Journal of Veterinary Research 47, 1817–1825Google Scholar
  73. 73.
    Bortell, R., Asquith, R.L., Edds, G.T., Simpson, C.F., Aller, W.W., 1983: Acute experimentally induced aflatoxicosis in the weanling pony. American Journal of Veterinary Research 44, 2110–2114Google Scholar
  74. 74.
    Garner, C.R., 1975: Reduction in binding of [14C] aflatoxin B1 to rat liver macromolecules by phenobarbitone pretreatment. Biochemical Pharmacology 24, 1553–1556Google Scholar
  75. 75.
    Gregory, J.F., III, Manley, D., 1981: High performance liquid chromatographic determination of aflatoxins in animal tissues and products. Journal of the Association of Official Analytical Chemists. 64, 144–151Google Scholar
  76. 76.
    Ray, A.C., Abitt, B., Cotter, S.R., Murphy, M.J., Reagor, J.C., Robinson, R.M., West, J.E., Whitford, H.W., 1986: Bovine abortion and death associated with consumption of aflatoxin-contaminated peanuts. Journal of American Veterinary Medical Association 188, 1187–1188Google Scholar
  77. 77.
    Harvey, R.B., Phillips, T.D., Ellis, J.A., Kubena, L.F., Huff, W.E., Petersen, H.D., 1991: Effects on aflatoxin M1 residues in milk by addition of hydrated sodium calcium aluminosilicate to aflatoxin-contaminated diets of dairy cows. American Journal of Veterinary Research 52, 1556–1559Google Scholar
  78. 78.
    Lewis, R.E., Wiederhold, N.P., Chi, J., Han, X.Y., Komanduri, K.V., Kontoyiannis, D.P., Prince, R.A., 2005: Detection of gliotoxin in experimental and human aspergillosis. Infection and Immunity 73, 635–637Google Scholar
  79. 79.
    Prelusky, D.B., Scott, P.M., Trenholm, H.L., Lawrence, G.A., 1990: Minimal transmission of zearalenone to milk of dairy cows. Journal of Environmental Science and Health B 25, 87–103Google Scholar
  80. 80.
    Cheng, Z., Root, M., Pan, W., Chen, J., Campbell, T.C., 1997: Use of an improved method for analysis of urinary aflatoxin M1 in a survey of mainland China and Taiwan. Cancer Epidemiology, Biomarkers & Prevention 6, 523–529Google Scholar
  81. 81.
    Sawhney, D.S., Vadehra, D.V., Baker, R.C., 1972: The metabolism of 14C aflatoxins in laying hens. Poultry Science 52, 1302–1309Google Scholar
  82. 82.
    Richard, J.L., Dvorak, T.J., Ross, P.F., 1996: Natural occurrence of gliotoxin in turkeys infected with Aspergillus fumigatus, Fresenius. Mycopathologia 134, 167–170Google Scholar
  83. 83.
    Applebaum, R.S., Brackett, R.E., Wiseman, D.W., Marth, E.H., 1982: Responses of dairy cows to dietary aflatoxin: feed intake and yield, toxin content, and quality of milk of cows treated with pure and impure aflatoxin. Journal of Dairy Science 65, 1503–1508Google Scholar
  84. 84.
    James, L.J., Smith, T.K., 1982: Effect of dietary alfalfa on zearalenone toxicity and metabolism in rats and swine. Journal of Animal Science 55, 110–118Google Scholar
  85. 85.
    Munksgaard, L., Larsen, J., Werner, H., Andersen, P.E., Viuf, B.T., 1987: Carry over of aflatoxin from cows’ feed to milk and milk products. Milchwissenschaft 42, 165–167Google Scholar
  86. 86.
    Fremy, J.M., Gautier, J.P., Herry, M.P., Terrier, C., Calet, C., 1987: Effects of ammoniation on the ‘carry-over’ of aflatoxins into bovine milk. Food Additives and Contaminants 5, 39–44Google Scholar
  87. 87.
    Fodor, J., Meyer, K., Riedlberger, M., Bauer, J., Horn, P., Kovács, F., Kovács, M., 2006: Distribution and elimination of fumonisin analogues in weaned piglets after oral administration of Fusarium verticillioides fungal culture. Food Additives and Contaminants 23, 492–501Google Scholar
  88. 88.
    Jemmali, M., Murthy, T.R.K., 1976: A chemical assay method for the determination of aflatoxin residues in animal tissues. Zeitschrift für Lebensmittel-Untersuchung und -Forschung 161, 13–17Google Scholar
  89. 89.
    Kiermeier, F., 1973: Aflatoxin M secretion in cow’s milk depending on the quantity of aflatoxin B1 ingested. Milchwissenschaften 28, 683–685 [German]Google Scholar
  90. 90.
    Mintzlaff, H.-J., Lötzsch, R., Tauchmann, F., Meyer, W., Leistner, L., 1974: Aflatoxin-Rückstände in der Leber und in der Muskulatur von Masthähnchen nach Verabreichung von aflatoxinhaltigen Futtermitteln. Fleischwirtschaft 54, 774–778 [German]Google Scholar
  91. 91.
    de Vries, H.R., Maxwell, S.M., Hendrickse, R.G., 1990: Aflatoxin excretion in children with kwashiorkor or marasmic kwashiorkor – a clinical investigation. Mycopathologia 110, 1–9Google Scholar
  92. 92.
    Trucksess, M.W., Richard, J.L., Stoloff, L., Mc Donald, J.S., Brumley, W.C., 1983: Absorption and distribution patterns of aflatoxicol and aflatoxins B1 and M1 in blood and milk of cows given aflatoxin B1. American Journal of Veterinary Research 44, 1753–1756Google Scholar
  93. 93.
    Stubblefield, R.D., Pier, A.C., Richard, J.L., Shotwell, O.L., 1983: Fate of aflatoxins in tissues, fluids, and excrements from cows dosed orally with aflatoxin B1. American Journal of Veterinary Research 44, 1750–1752Google Scholar
  94. 94.
    Hussain, M., Gabal, M.A., Wilson, T, Summerfelt, R.C., 1993: Effect of aflatoxin-contaminated feed on morbidity and residues in walleye fish. Veterinary and Human Toxicology 35, 396–398Google Scholar
  95. 95.
    de Vries, H.R., Lamplugh, S.M., Hendrickse, R.G., 1987: Aflatoxins and kwashiorkor in Kenya: a hospital based study in a rural area of Kenya. Annals of Tropical Paediatrics 7, 249–251Google Scholar
  96. 96.
    Corbett, W.T., Brownie, C.F., Hagler, S.B., Hagler, W.M., 1988: An epidemiological investigation asssociating aflatoxin M1 with milk production in dairy cattle. Veterinary and Human Toxicology 30, 5–8Google Scholar
  97. 97.
    Micco, C., Ambruzzi, M.A., Miraglia, M., Brera, C., Onori, R., Benelli, L., 1991: Contamination of human milk with ochratoxin A. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Eds. Castegnaro, M., Pleština, R., Dirheimer, G., Chernozemsky, I.N., Bartsch, H. Lyon, International Agency for Research on Cancer (IARC), pp. 105–108Google Scholar
  98. 98.
    Shank, R., Johnsen, D.O., Tanticharoenyos, P., Wooding, W.L., Bourgeois, C.H., 1971: Acute toxicity of aflatoxin B1 in the Macaque monkey. Toxicology and Applied Pharmacology 20, 227–231Google Scholar
  99. 99.
    Keskin, Y., Başkaya, R., Karsli, S., Yurdun, T., Özyaral, O., 2009: Detection of aflatoxin M1 in human breast milk and raw cow’s milk in Istanbul, Turkey. Journal of Food Protection 72, 885–889Google Scholar
  100. 100.
    Groopman, J.D., Trudel, L.J., Donahue, P.R., Marshak-Rothstein, A., Wogan, G.N., 1984: High-affinity monoclonal antibodies for aflatoxins and their application to solid-phase immunoassays. Proceedings of the National Academy of Science USA 81, 7728–7731Google Scholar
  101. 101.
    Krogh, P., Hald, B., Hasselager, E., Madsen, A., Mortensen, H.P., Larsen, A.E., Campbell, A.D., 1973: Aflatoxin residues in bacon pigs. Pure & Applied Chemistry 35, 275–281Google Scholar
  102. 102.
    Krogh, P., Elling, F., Hald, B., Larsen, A.E., Lillehoj, E.B., Madsen, A., Mortensen, H.P., 1976: Time-dependent disappearance of ochratoxin A residues in tissues of bacon pigs. Toxicology 6, 235–242Google Scholar
  103. 103.
    Groopman, J.D., Haugen, A., Goodrich, G.R., Wogan, G.N., Harris, C.C., 1982: Quantitation of aflatoxin B1-modified DNA using monoclonal antibodies. Cancer Research 42, 3120–3124Google Scholar
  104. 104.
    Hatch, M.C., Chen, C.-J., Levin, B., Ji, B.-T., Yang, G.-Y., Hsu, S.-W., Wang, L.-W., Hsieh, L.-L., Santella, R.M., 1993: Urinary aflatoxin levels, hepatitis-B virus infection and hepatocellular carcinoma in Taiwan. International Journal of Cancer 54, 931–934Google Scholar
  105. 105.
    Gregory, J.F., III, Goldstein, S.L., Edds, G.T., 1983: Metabolite distribution and rate of residue clearance in turkeys fed a diet containing aflatoxin B1. Food and Chemical Toxicology 21, 463–467Google Scholar
  106. 106.
    Mirocha, C.J., Robison, T.S., Pawlosky, R.J., Allen, N.K., 1982: Distribution and residue determination of [3H]zearalenone in broilers. Toxicology and Applied Pharmacology 66, 77–87Google Scholar
  107. 107.
    Price, R.L., Lough, O.G., Brown, W.H., 1982: Ammoniation of whole cottonseed at atmospheric pressure and ambient temperature to reduce aflatoxin M1 in milk. Journal of Food Protection 45, 341–344Google Scholar
  108. 108.
    Prelusky, D.B., Miller, J.D., Trenholm, H.L., 1996: Disposition of 14C-derived residues in tissues of pigs fed radiolabelled fumonisin B1. Food Additives and Contaminants 13, 155–162Google Scholar
  109. 109.
    Meyer, K., Mohr, K., Bauer, J., Horn, P., Kovács, M., 2003: Residue formation of fumonisin B1 in porcine tissues. Food Additives and Contaminants 20, 639–647Google Scholar
  110. 110.
    Wolzak, A., Pearson, A.M., Coleman, T.H., Pestka, J.J., Gray, J.I., Chen, C., 1986: Aflatoxin carryover and clearance from tissues of laying hens. Food and Chemical Toxicology 24, 37–41Google Scholar
  111. 111.
    Norred, W.P., Morrissey, R.E., Riley, R.T., Cole, R.J., Dorner, J.W., 1985: Distribution, excretion and skeletal muscle effects of the mycotoxin [14C]cyclopiazonic acid in rats. Food and Chemical Toxicology 23, 1069–1076Google Scholar
  112. 112.
    Wolzak, A., Pearson, A.M., Coleman, T.H., Pestka, J.J., Gray, J.I., 1985: Aflatoxin deposition and clearance in the eggs of laying hens. Food and Chemical Toxicology 23, 1057–1061Google Scholar
  113. 113.
    Hayes, A.W., King, R.E., Unger, P.D., Phillips, T.D., Hatkin, J., Bowen, J.H., 1978: Aflatoxicosis in swine. Journal of the American Veterinary Medical Association 172, 1295–1297Google Scholar
  114. 114.
    Shephard, G.S., Thiel, P.G., Sydenham, E.W., 1992: Initial studies on the toxicokinetics of fumonisin B1 in rats. Food and Chemical Toxicology 30, 277–279Google Scholar
  115. 115.
    Bailey, G.S., Williams, D.E., Wilcox, J.S., Loveland, P.M., Coulombe, R.A., Hendricks, J.D., 1988: Aflatoxin B1 carcinogenesis and its relation to DNA adduct formation and adduct persistence in sensitive and resistant salmoid fish. Carcinogenesis 9, 1919–1926Google Scholar
  116. 116.
    Garner, R.C., Martin, C.N., Lindsay Smith, J.R., Coles, B.F., Tolson, M.R., 1979: Comparison of aflatoxin B1 and aflatoxin G1 binding to cellular macromolecules in vitro, in vivo and after peracid oxidation; characterisation of the major nucleic acid adducts. Chemico-Biological Interactions 26, 57–73Google Scholar
  117. 117.
    Hendrickse, R.G., Maxwell, S.M., Young, R., 1989: Aflatoxins and heroin. British Medical Journal 299, 492–493Google Scholar
  118. 118.
    Preston, R.S., Hayes, J.R., Campbell, T.C., 1976: The effect of protein deficiency on the in vivo binding of aflatoxin B1 to rat liver macromolecules. Life Sciences 19, 1191–1198Google Scholar
  119. 119.
    Olsen, M., Mirocha, C.J., Abbas, H.K., Johansson, B., 1986: Metabolism of high concentrations of dietary zearalenone by young male turkey poults. Poultry Science 65, 1905–1910Google Scholar
  120. 120.
    Monroe, D.H., Holeski, C.J., Eaton, D.L., 1986: Effects of single-dose and repeated-dose pretreatment with 2(3)-tert-butyl-4-hydroxyanisole (BHA) on the hepatobiliary disposition and covalent binding to DNA of aflatoxin B1 in the rat. Food and Chemical Toxicology 24, 1273–1281Google Scholar
  121. 121.
    Yang, G., Nesheim, S., Benavides, J., Ueno, I., Campbell, A.D., Pohland, A., 1980: Radioimmunoassay detection of aflatoxin B1 in monkey and human urine. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene Abt. 1 Originale A 246 (Suppl. 8), 329–335Google Scholar
  122. 122.
    Richir, C., Paccalin, J., Faugeres, R., Moreux, M., Audry, S., N’Diaye, P., 1980: Searching for mycotoxins in human body fluids and viscera. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene Abt. 1 Originale A 246 (Suppl. 8), 337–342Google Scholar
  123. 123.
    Hagler, W.M., Dankó, G., Horváth, L., Palyusik, M., Mirocha, C.J., 1980: Transmission of zearalenone and its metabolite into ruminant milk. Acta Veterinaria Academiae Scientiarum Hungaricae 28, 209–216Google Scholar
  124. 124.
    Li, Y.K., Chu, F.S., 1982: Kinetics of transmission of aflatoxin B1 into aflatoxin M1 in lactating mouse: an ELISA analysis. Experientia 38, 842–843Google Scholar
  125. 125.
    Zepnik, H., Völkel, W., Dekant, W., 2003: Metabolism and toxicokinetics of the mycotoxin ochratoxin A in F344 rats. Mycotoxin Research 19, 102–107Google Scholar
  126. 126.
    Bauer, J., Gareis, M., Bott, A., Gedek, B., 1989: Isolation of a mycotoxin (gliotoxin) from a bovine udder infected with Aspergillus fumigatus. Journal of Medical and Veterinary Mycology 27, 45–50Google Scholar
  127. 127.
    Shephard, G.S., Snijman, P.W., 1999: Elimination and excretion of a single dose of the mycotoxin fumonisin B2 in a non-human primate. Food and Chemical Toxicology 37, 111–116Google Scholar
  128. 128.
    Biehl, M.L., Prelusky, D.B., Koritz, G.D., Hartin, K.E., Buck, W., Trenholm, H.L., 1993: Biliary excretion and enterohepatic cycling of zearalenone in immature pigs. Toxicology and Applied Pharmacology 121, 152–159Google Scholar
  129. 129.
    Vudathala, D.K., Prelusky, D.B., Ayroud, M., Trenholm, H.L., Miller, J.D., 1994: Pharmacokinetic fate and pathological effects of 14C-fumonisin B1 in laying hens. Natural Toxins 2, 81–88Google Scholar
  130. 130.
    Shephard, G.S., Thiel, P.G., Sydenham, E.W., Savard, M.E., 1995: Fate of single dose of 14C-labelled fumonisin B1 in vervet monkeys. Natural Toxins 3,145–150Google Scholar
  131. 131.
    Holzapfel, C.W., Steyn, P.S., Purchase, I.F.H., 1966: Isolation and structure of aflatoxins M1 and M2. Tetrahedron Letters 25, 2799–2803Google Scholar
  132. 132.
    Chou, M.-W., Tung, T.-C., 1969: Aflatoxin B1 in the excretion of aflatoxin poisoned rats. Journal of the Formosan Medical Association 68, 389–391Google Scholar
  133. 133.
    Swenson, D.H., Lin, J.-K., Miller, E.C., Miller, J.A., 1977: Aflatoxin B1–2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo. Cancer Research 37, 172–181Google Scholar
  134. 134.
    Coulter, J.B.S., Lamplugh, S.M., Suliman, G.I., Omer, I.A., Hendrickse, R.G., 1984: Aflatoxins in human breast milk. Annals of Tropical Paediatrics 4, 61–66Google Scholar
  135. 135.
    Prelusky, D.B., Hamilton, R.M.G., Trenholm, H.L., Miller, J.D., 1986: Tissue distribution and excretion of radioactivity following administration of 14C-labelled deoxynivalenol to White Leghorn hens. Fundamental and Applied Toxicology 7, 635–645Google Scholar
  136. 136.
    Jacobson, W.C., Harmeyer, W.C., Jackson, J.E., Armbrecht, B., Wiseman, H.G., 1978: Transmission of aflatoxin B1 into the tissues of growing pigs. Bulletin of Environmental Contamination & Toxicology 19, 156–161Google Scholar
  137. 137.
    Polan, C.E., Hayes, J.R., Campbell, T.C., 1974: Consumption and fate of aflatoxin B1 by lactating cows. Journal of Agricultural and Food Chemistry 22, 635–638Google Scholar
  138. 138.
    Furtado, R.M., Pearson, A.M., Hogberg, M.G., Miller, E.R., 1979: Aflatoxin residues in the tissues of pigs fed a contaminated diet. Journal of Agricultural and Food Chemistry 27, 1351–1354Google Scholar
  139. 139.
    Jacobson, W.C., Wiseman, H.G., 1974: The transmission of aflatoxin B1 into eggs. Poultry Science 53, 1743–1745Google Scholar
  140. 140.
    Gong, Y.Y., Cardwell, K, Hounsa, A., Egal, S., Turner, P.C., Hall, A.J., Wild, C.P., 2002: Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. British Medical Journal 325, 20–21Google Scholar
  141. 141.
    Angsubhakorn, S., Poomvises, P., Romruen, K., Newberne, P.M., 1981: Aflatoxicosis in horses. Journal of American Veterinary Association 178, 274–278Google Scholar
  142. 142.
    Egner, P.A., Yu, X., Johnson, J.K., Nathasingh, C.K., Groopman, J.D., Kensler, T.W., Roebuck, B.D., 2003: Identification of aflatoxin M1-N 7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1. Chemical Research in Toxicology 16, 1174–1180Google Scholar
  143. 143.
    Suzuki, S., Satoh, T., Yamazaki, M., 1977: The pharmacokinetics of ochratoxin A in rats. Japanese Journal of Pharmacology 27, 735–744Google Scholar
  144. 144.
    Li, S., Marquardt, R.R., Frohlich, A.A., 2000: Identification of ochratoxins and some of their metabolites in bile and urine of rats. Food and Chemical Toxicology 38, 141–152Google Scholar
  145. 145.
    Visconti, A., Mirocha, C.J., 1985: Identification of various T-2 toxin metabolites in chicken excreta and tissues. Applied and Environmental Microbiology 49, 1246–1250Google Scholar
  146. 146.
    Richard, J.L., Pier, A.C., Stubblefield, R.D., Shotwell, O.L., Lyon, R.L., Cutlip, R.C., 1983: Effect of feeding corn naturally contaminated with aflatoxin on feed efficiency, on physiologic, immunologic, and pathologic changes, and on tissue residues in steers. American Journal of Veterinary Research 44, 1294–1299Google Scholar
  147. 147.
    Applebaum, R.S., Marth, E.H., 1980: Responses of a dairy cow to dietary aflatoxin: preliminary report. Journal of Dairy Science 63 Suppl. 1, 58Google Scholar
  148. 148.
    Palyusik, M., Harrach, B., Mirocha, C.J., Pathre, S.V., 1980: Transmission of zearalenone and zearalenol into porcine milk. Acta Veterinaria Academiae Scientiarum Hungaricae 28, 217–222Google Scholar
  149. 149.
    Gareis, M., Wernery, U., 1984: Determination of gliotoxin in samples associated with cases of intoxication in camels. Mycotoxin Research 10, 2–8Google Scholar
  150. 150.
    McKinney, J.D., Cavanagh, G.C., Bell, J.T., Hoversland, A.S., Nelson, D.M., Pearson, J., Selkirk, R.J., 1973: Effects of ammoniation on aflatoxins in rations fed lactating cows. Journal of the American Oil Chemists’ Society 50, 79–84Google Scholar
  151. 151.
    Stubblefield, R.D., Shotwell, O.L., Richard, J.L., Pier, A.C., 1981: Transmission and distribution of aflatoxin in contaminated beef liver and other tissues. Journal of the American Oil Chemists’ Society 58, 1015A–1017AGoogle Scholar
  152. 152.
    Nyathi, C.B., Mutiro, C.F., Hasler, J.A., Chetsanga, C.J., 1987: A survey of urinary aflatoxin in Zimbabwe. International Journal of Epidemiology 16, 516–519Google Scholar
  153. 153.
    Garner, R.C., Dvorackova, I., Tursi, F., 1988: Immunoassay procedures to detect exposure to aflatoxin B1 and benzo(a)pyrene in animals and man at the DNA level. International Archives of Occupational and Environmental Health 60, 145–150Google Scholar
  154. 154.
    Irvin, T.R., Wogan, G.N., 1984: Quantitation of aflatoxin B1 adduction within the ribosomal RNA gene sequence of rat liver DNA. Proceedings of the National Academy of Science USA 81, 664–668Google Scholar
  155. 155.
    Haugen, A., Groopman, J.D., Hsu, I.-C., Goodrich, G.R., Wogan, G.N., Harris, C.C., 1981: Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay. Proceedings of the National Academy of Science USA 78, 4124–4127Google Scholar
  156. 156.
    Hsieh, L.-L., Hsieh, T.-T., 1993: Detection of aflatoxin B1-DNA adducts in human placenta and cord blood. Cancer Research 53, 1278–1280Google Scholar
  157. 157.
    Frobish, R.A., Bradley, B.D., Wagner, D.D., Long-Bradley, P.E., Hairston, H, 1986: Aflatoxin residues in milk of dairy cows after ingestion of naturally contaminated grain. Journal of Food Protection 49, 781–785Google Scholar
  158. 158.
    Fukal, L., Březina, P., 1991: Determination of the aflatoxin M1-level in milk for the production of milk baby foods using immunoassay. Nahrung 35, 745–748 [German]Google Scholar
  159. 159.
    Fukal, L., Březina, P., Marek, M., 1990: Immunochemical monitoring of aflatoxin M1 occurrence in milk produced in Czechoslovakia. Deutsche Lebensmittel-Rundschau 86, 289–291Google Scholar
  160. 160.
    Gajek, O., 1982: Aflatoxins in protein food for animals and milk. Roczniki Panstwowego Zaklado Higieny XXXIII, 415–420 [Polish]Google Scholar
  161. 161.
    Gallo, P., Salzillo, A., Rossini, C., Urbani, V., Serpe, L., 2006: Aflatoxin M1 determination in milk: method validation and contamination levels in samples from southern Italy. Italian Journal of Food Science 18, 251–259Google Scholar
  162. 162.
    Gelosa, L., 1986: La presenza di aflatossina M1 nel latte al consumo. Latte XI, 261–264 [Italian]Google Scholar
  163. 163.
    Gilbert, J., Shepherd, M.J., Wallwork, M.A., Knowles, M.E., 1984: A survey of the occurrence of aflatoxin M1 in UK-produced milk for the period 1981–1983. Food Additives and Contaminants 1, 23–28Google Scholar
  164. 164.
    Ioannou-Kakouri, E., Aletari, M., Christou, E., Hadjioannou, A., Koliou, A., Akkelidou, D., 1999: Surveillance and control of aflatoxins B1, B2, G1, G2, and M1 in foodstuffs in the Republic of Cyprus: 1992–1996. Journal of the Association of Official Analytical Chemists International 82, 883–892Google Scholar
  165. 165.
    Jalón, M., Urieta, I, de Pablo, B., Macho, M.L., 1994: Contaminacion por aflatoxina M1 de leche y productos lacteos en la comunidad autónoma Vasca. Alimentaria 3, 25–29 [Spanish]Google Scholar
  166. 166.
    Karaioannoglou, P., Mantis, A., Koufidis, D., Koidis, P., Triantafillou, J., 1989: Occurrence of aflatoxin M1 in raw and pasteurized milk and in Feta and Telme cheese samples. Milchwissenschaft 44, 746–748Google Scholar
  167. 167.
    Li, Y., Su, J.-j., Qin, L.-l., Egner, P.E., Wang, J.-S., Groopman, J.D., Kensler, T.W., Roebuck, B.D., 2000: Reduction of aflatoxin B1 adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis). Cancer Letters 154, 79–83Google Scholar
  168. 168.
    Nayak, S., Tanuja, P., Sashidhar, R.B., 2009: Synthesis and characterization of mercapturic acid (N-acetyl-L-cysteine)-aflatoxin B1 adduct and its quantitation in rat urine by an enzyme immunoassay. Journal of the Association of Official Analytical Chemists International 92, 487–495Google Scholar
  169. 169.
    Masri, M.S., Garcia, V.C., Page, J.R. 1969: The aflatoxin M content of milk from cows fed known amounts of aflatoxin. Veterinary Record 84, 146–147Google Scholar
  170. 170.
    Pietri, A., Bertuzzi, T., Moschini, M., Piva, G., 2003: Aflatoxin M1 occurrence in milk samples destined for Parmigiano Reggiano cheese production. Italian Journal of Food Science 15, 301–306Google Scholar
  171. 171.
    Allcroft, R., Roberts, B.A., 1968: Toxic groundnut meal: the relationship between aflatoxin B1 intake by cows and excretion of aflatoxin M1 in milk. Veterinary Record 82, 116–118Google Scholar
  172. 172.
    Galtier, P., Alvinerie, M., Charpenteau, J.L., 1981: The pharmacokinetic profiles of ochratoxin A in pigs, rabbits and chickens. Food and Cosmetics Toxicology 19, 735–738Google Scholar
  173. 173.
    Croy, R.G., Essigmann, J.M., Reinhold, V.N., Wogan, G.N., 1978: Identification of the principal aflatoxin B1-DNA adduct formed in vivo in rat liver. Proceedings of the National Academy of Science USA 75, 1745–1749Google Scholar
  174. 174.
    Kumagai, S., Aibara, K., 1982: Intestinal absorption and secretion of ochratoxin A in the rat. Toxicology and Applied Pharmacology 64, 94–102Google Scholar
  175. 175.
    Li, S., Marquardt, R.R., Frohlich, A.A., Vitti, T.G., Crow, G., 1997: Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicology and Applied Pharmacology 145, 82–90Google Scholar
  176. 176.
    Walton, M., Egner, P, Scholl, P.F., Walker, J., Kensler, T.W., Groopman, J.D., 2001: Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats. Chemical Research in Toxicology 14, 919–926Google Scholar
  177. 177.
    Whitham, M., Nixon, J.E., Sinnhuber, R.O., 1982: Liver DNA bound in vivo with aflatoxin B1 as a measure of hepatocarcinoma initiation in rainbow trout. Journal of the National Cancer Institue 68, 623–628Google Scholar
  178. 178.
    Ghidini, S., Zanardi, E., Battaglia, A., Varisco, G., Ferretti, E., Campanini, G., Chizzolini, R., 2005: Comparison of contaminant and residue levels in organic and conventional milk and meat products from nothern Italy. Food Additives and Contaminants 22, 9–14Google Scholar
  179. 179.
    Sreemannarayana, O., Frohlich, A.A., Vitti, T.G., Marquardt, R.R., Abramson, D., 1988: Studies of the tolerance and disposition of ochratoxin A in young calves. Journal of Animal Science 66, 1703–1711Google Scholar
  180. 180.
    Chatterjee, K., Pawlowsky, R.J., Treeful, L., Mirocha, C.J., 1986: Kinetic study of T-2 toxin metabolites in a cow. Journal of Food Safety 8, 25–34Google Scholar
  181. 181.
    Ballinger, M.B., Phillips, T.D., Kubena, L.F., 1986: Assessment of the distribution and elimination of ochratoxin A in the pregnant rat. Journal of Food Safety 8, 11–24Google Scholar
  182. 182.
    Miller, D.M., Wilson, D.M., Wyatt, R.D., McKinney, J.K., Crowell, W.A., Stuart, B.P., 1982: High performance liquid chromatographic determination and clearance time of aflatoxin residues in swine tissues. Journal of the Association of Official Analytical Chemists 65, 1–4Google Scholar
  183. 183.
    Fukayama, M.Y., Helferich, W.G., Hsieh, D.P.H., 1984: Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat. Food and Chemical Toxicology 11, 857–860Google Scholar
  184. 184.
    Hassen, W., Abid, S., Achour, A., Creppy, E., Bacha, H., 2004: Ochratoxin A and ß2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of ochratoxin A exposure. Toxicology 199, 185–193Google Scholar
  185. 185.
    Maaroufi, K., Acour, A., Hammami, M., El May, M., Betbeder, A.M., Ellouz, F., Creppy, E.E., Bacha, H., 1995: Ochratoxin A in human blood in relation to nephropathy in Tunisia. Human & Experimental Toxicology 14, 609–615Google Scholar
  186. 186.
    Dvořáčková, I., Pichová, V., 1986: Pulmonary interstitial fibrosis with evidence of aflatoxin B1 in lung tissue. Journal of Toxicology and Environmental Health 18, 153–157Google Scholar
  187. 187.
    Peraica, M., Domijan, A.-M., Fuchs, R., Lucić, A., Radić, B., 1999: The occurrence of ochratoxin A in blood in general population of Croatia. Toxicology Letters 110, 105–112Google Scholar
  188. 188.
    Radić, B., Fuchs, R., Peraica, M., Lucić, A., 1997: Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicology Letters 91, 105–109Google Scholar
  189. 189.
    Peraica, M., Domijan, A.-M., Matašin, M., Lucić, A., Radić, B., Delaš, F., Horvat, M., Bosanac, I., Balija, M., Grgičević, D., 2001: Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities. Archives of Toxicology 75, 410–414Google Scholar
  190. 190.
    Wild, C.P., Umbenhauer, D., Chapot, B., Montesano, R., 1986: Monitoring of individual human exposure to aflatoxins (AF) and N-nitrosamines (NNO) by immunoassays. Journal of Cellular Biochemistry 30, 171–179Google Scholar
  191. 191.
    Fuchs, R., Radić, B., Peraica, M., Hult, K., Pleština, R., 1988: Enterohepatic circulation of ochratoxin A in rats. Periodicum Biologorum 90, 39–42Google Scholar
  192. 192.
    Kovács, F., Sándor, G., Ványi, A., Domány, S., Zomborszky-Kovács, M., 1995: Detection of ochratoxin A in human blood and colostrum. Acta Veterinaria Hungarica 43, 393–400Google Scholar
  193. 193.
    Hagelberg, S., Hult, K., Fuchs, R., 1989: Toxicokinetics of ochratoxin A in several species and its plasma-binding properties. Journal of Applied Toxicology 9, 91–96Google Scholar
  194. 194.
    Watson, F.A., Mirocha, C.J., Hayes, A.W., 1984: Analysis for trichothecenes in samples from southeast Asia associated with „Yellow Rain“. Fundamental and Applied Toxicology 4, 700–717Google Scholar
  195. 195.
    Sodeinde, O., Chan, M.C.K., Maxwell, S.M., Familusi, J.B., Hendrickse, R.G., 1995: Neonatal jaundice, aflatoxins and naphthols: report of a study in Ibadan, Nigeria. Annals of Tropical Paediatrics 15, 107–113Google Scholar
  196. 196.
    Breitholtz-Emanuelsson, A., Minervini, F., Hult, K., Visconti, A., 1994: Ochratoxin A in human serum samples collected in southern Italy from healthy individuals and individuals suffering from different kidney disorders. Natural Toxins 2, 366–370Google Scholar
  197. 197.
    Studer-Rohr, I., Schlatter, J., Dietrich, D.R., 2000: Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Archives of Toxicology 74, 499–510Google Scholar
  198. 198.
    Fuchs, R., Hult, K., Peraica, M., Radič, B., Pleština, R., 1984: Conversion of ochratoxin C into ochratoxin A in vivo. Applied and Environmental Microbiology 48, 41–42Google Scholar
  199. 199.
    Kiessling, K.-H., Pettersson, H., Sandholm, K., Olsen, M., 1984: Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Applied and Environmental Microbiology 47, 1070–1073Google Scholar
  200. 200.
    Xiao, H, Marquardt, R.R., Frohlich, A.A., Phillips, G.D., Vitti, T.G., 1991: Effect of hay and a grain diet on the rate of hydrolysis of ochratoxin A in the rumen of sheep. Journal of Animal Science 69, 3706–3714Google Scholar
  201. 201.
    Micco, C., Brera, C., Miraglia, M., Onori, R., 1987: HPLC determination of the total content of aflatoxins in naturally contaminated eggs in free and conjugate forms. Food Additives and Contaminants 4, 407–414Google Scholar
  202. 202.
    Grosso, F., Saïd, S., Mabrouk, I., Fremy, J.M., Castegnaro, M., Jemmali, M., Dragacci, S., 2003: New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food and Chemical Toxicology 41, 1133–1140Google Scholar
  203. 203.
    Szuets, P., Mesterhazy, A., Falkay, G.Y., Bartok, T., 1997: Early telarche symptoms in children and their relations to zearalenon contamination in foodstuffs. Cereal Research Communications 25, 429–436Google Scholar
  204. 204.
    Mortensen, H.P., Hald, B., Madsen, A., 1983: Feeding experiments with ochratoxin A contaminated barley for bacon pigs. 5. Ochratoxin A in pig blood. Acta Agriculturœ Scandinavica 33, 235–239Google Scholar
  205. 205.
    Maxwell, S.M., Familusi, J.B., Sodeinde, O., Chan, M.C.K., Hendrickse, R.G., 1994: Detection of naphthols and aflatoxins in Nigerian cord blood. Annals of Tropical Paediatrics 14, 3–5Google Scholar
  206. 206.
    Plestina, R., Ceović, S., Gatenbeck, S., Habazin-Novak, V., Hult, K., Hökby, E., Krogh, P., Radić, B., 1990: Human exposure to ochratoxin A in areas of Yugoslavia with endemic nephropathy. Journal of Environmental Pathology, Toxicology, Oncology 10, 145–148Google Scholar
  207. 207.
    Solti, L., Salamon, F., Barna-Vetró, I., Gyöngyösi, Á., Szabó, E., Wölfling, A., 1997: Ochratoxin A content of human sera determined by a sensitive ELISA. Journal of Analytical Toxicology 21, 44–48Google Scholar
  208. 208.
    Palli, D., Miraglia, M., Saieva, C., Masala, G., Cava, E., Colatosti, M., Corsi, A.M., Russo, A., Brera, C., 1999: Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidemiology, Biomarkers & Prevention 8, 265–269Google Scholar
  209. 209.
    van Walbeek, W., Moodie, C.A., Scott, P.M., Harwig, J., Grice, H.C., 1971: Toxicity and excretion of ochratoxin A in rats intubated with pure ochratoxin A or fed cultures of Penicillium viridicatum. Toxicology and Applied Pharmacology 20, 439–441Google Scholar
  210. 210.
    Patterson, D.S.P., Shreeve, B.J., Roberts, B.A., Berrett, S., Brush, P.J., Glancy, E.M., Krogh, P., 1981: Effect on calves of barley naturally contaminated with ochratoxin A and groundnut meal contaminated with low concentrations of aflatoxin B1. Research in Veterinary Science 31, 213–218Google Scholar
  211. 211.
    Veldman, A., Meijs, J.A.C., Borggreve, G.J., Heeres-van der Tol, J.J., 1992: Carry-over of aflatoxin from cows’ food to milk. Animal Production 55, 163–168Google Scholar
  212. 212.
    Goeger, D.E., Shelton, D.W., Hendricks, J.D., Bailey, G.S., 1986: Mechanisms of anti-carcinogenesis by indole-3-carbinol: effect on the distribution and metabolism of aflatoxin B1 in rainbow trout. Carcinogenesis 7, 2025–2031Google Scholar
  213. 213.
    Shelton, D.W., Goeger, D.E., Hendricks, J.D., Bailey, G.S., 1986: Mechanisms of anti-carcinogenesis: the distribution and metabolism of aflatoxin B1 in rainbow trout fed Arocolor 1254. Carcinogenesis 7, 1065–1071Google Scholar
  214. 214.
    Wild, C.P., Montesano, R., van Bethem, J., Scherer, E., Den Engelse, L., 1990: Intercellular variation in levels of adducts of aflatoxin B1 and G1 in DNA from rat tissue: a quantitative immunocytochemical study. Journal of Cancer Research and Clinical Oncology 116, 134–140Google Scholar
  215. 215.
    Eko-Ebongue, S., Antalick, J.-P., Bonini, M., Betbeder, A.-M., Faugère, J.-G., Maaroufi, K., Bacha, H., Achour, M., Grosse, Y., Pfohl-Leszkowicz, A., Creppy, E.E., 1994: Détermination des teneurs en ochratoxine A, vitamine E et vitamine A dans des sérums humains de France et de Tunisie: recherche dúne corrélation. Annales des Falsifications et de l’Éxpertise Chimique et Toxicologique 929, 213–224Google Scholar
  216. 216.
    Bagni, A., Castagnetti, G.B., Chiavari, C., Ferri, G., Losi, G., Montanari, G., 1993: A study about aflatoxin M1 and M2 in dairy cow milk samples collected in the province of Reggio Emilia. L’Industria del Latte XXIX, 55–66 [Italian]Google Scholar
  217. 217.
    El-Nezami, H., Mykkänen, H., Kankaanpää, P., Suomalainen, T., Salminen, S., Ahokas, J., 2000: Ability of a mixture of Lactobacillus and Propionibacterium to influence the faecal aflatoxin content in healthy Egyptian volunteers: a pilot clinical study. Bioscience Microflora 19, 41–45Google Scholar
  218. 218.
    Chang, F.C., Chu, F.S., 1977: The fate of ochratoxin A in rats. Food and Cosmetics Toxicology 15, 199–204Google Scholar
  219. 219.
    Filali, A., Betbeder, A.M., Baudrimont, I., Benyada, A., Soulaymani, R., Creppy, E.E., 2002: Ochratoxin A in human plasma in Morocco: a preliminary survey. Human & Experimental Toxicology 21, 241–245Google Scholar
  220. 220.
    Özçelik, N., Koşar, A., Soysal, D., 2001: Ochratoxin A in human serum samples collected in Isparta-Turkey from healthy individuals and individuals suffering from different urinary disorders. Toxicology Letters 121, 9–13Google Scholar
  221. 221.
    Jiménez, A.M., López de Cerain, A., Gónzalez-Peňas, E., Bello, J., Bétbéder, A.M., Créppy, E.E., 1998: Exposure to ochratoxin A in Europe: comparison with a region of northern Spain. Journal of Toxicology – Toxin Reviews 17, 479–491Google Scholar
  222. 222.
    Ruprich, J., Ostrý, V., 1993: Study of human exposure to ochratoxin A and assessment of possible sources. Central European Journal of Public Health 1, 46–48Google Scholar
  223. 223.
    Sun, Z., Lu, P., Gail, M.H., Pee, D., Zhang, Q., Ming, L., Wang, J., Wu, Y., Liu, G., Wu, Y., Zhu, Y., 1999: Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 30, 379–383Google Scholar
  224. 224.
    Oyelami, O.A., Maxwell, S.M., Adelusola, K.A., Aladekoma, T.A., Oyelese, A.O., 1997: Aflatoxins in the lungs of children with kwashiorkor and children with miscellaneous diseases in Nigeria. Journal of Toxicology and Environmental Health 51, 623–628Google Scholar
  225. 225.
    Malir, F., Jergeova, Z., Severa, J., Cerna, M., Smid, J., Betbeder, A.M., Baudrimont, I., Creppy, E.E., 1998: The level of ochratoxin A in blood serum of adults in the Czech Republic. Revue de Médicine Vétérinaire 149, 710Google Scholar
  226. 226.
    Domijan, A.-M., Peraica, M., Fuchs, R., Lucić, A., Radić, B., Balija, M., Bosanac, I., Grgičević, D., 1999: Ochratoxin A in blood of healthy population in Zagreb. Archives of Industrial Hygiene and Toxicology 3, 263–271Google Scholar
  227. 227.
    Wafa, E.W., Yahya, R.S., Sobh, M.A., Eraky, I., El-Baz, M., El-Gayar, H.A.M., Betbeder, A.M., Creppy, E.E., 1998: Human ochratoxicosis and nephropathy in Egypt: a preliminary study. Human & Experimental Toxicology 17, 124–129Google Scholar
  228. 228.
    Bailey, G.S., Dashwood, R., Loveland, P.M., Pereira, C., Hendricks, J.D., 1998: Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout. Mutation Research 339, 233–244Google Scholar
  229. 229.
    Croy, R.G., Nixon, J.E., Sinnhuber, R.O., Wogan, G.N., 1980: Investigation of covalent aflatoxin B1-DNA adducts formed in vivo in rainbow trout (Salmo gairdneri) embryos and liver. Carcinogenesis 1, 903–909Google Scholar
  230. 230.
    Erasmuson, A.F., Scahill, B.C., West, D.M., 1994: Natural zeranol (α-zearalenol) in the urine of pasture-fed animals. Journal of Agricultural and Food Chemistry 42, 2721–2725Google Scholar
  231. 231.
    Galvano, F., Pietri, A., Bertuzzi, T., Fusconi, G., Galvano, M., Piva, A., Piva, G., 1996: Reduction of carryover of aflatoxin from cow feed to milk by addition of activated carbons. Journal of Food Protection 59, 551–554Google Scholar
  232. 232.
    Micco, C., Miraglia, M., Onori, R., Brera, C., Mantovani, A.L., Ioppolo, A., Stasolla, D., 1988: Long-term administration of low doses of mycotoxins to poultry. 1. Residues of aflatoxin B1 and its metabolites in broilers and laying hens. Food Additives and Contaminants 5, 303–308Google Scholar
  233. 233.
    Galvano, F., Pietri, A., Bertuzzi, T., Gagliardi, L., Ciotti, S., Luisi, S., Bognanno, M., la Fauci, L., Iacopino, A.M., Nigro, F., li Volti, G., Vanella, L., Giammanco, G., Tina, G.L., Gazzolo, D., 2008: Maternal dietary habits and mycotoxin occurrence in human mature milk. Molecular Nutrition & Food Research 52, 496–501Google Scholar
  234. 234.
    Tápai, K., Téren, J., Mesterházy, Á., 1997: Ochratoxin A in the sera of blood donors and ill persons. Cereal Research Communications 25, 307–308Google Scholar
  235. 235.
    Ueno, Y., Maki, S., Lin, J., Furuya, M., Sugiura, Y., Kawamura, O., 1998: A 4-year study of plasma ochratoxin A in a selected population in Tokyo by immunoassay and immunoaffinity column-linked HPLC. Food and Chemical Toxicology 36, 445–449Google Scholar
  236. 236.
    Gilbert, J., Brereton, P., MacDonald, S., 2001: Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples. Food Additives and Contaminants 18, 1088–1093Google Scholar
  237. 237.
    Krishnamachari, K.A., Bhat, R.V., Nagarajan, V., Tilak, T.B., 1975: Investigations into an outbreak of hepatitis in parts of western India. Indian Journal of Medical Research 63, 1036–1049Google Scholar
  238. 238.
    López, C.E., Ramos, L.L., Ramadán, S.S., Bulacio, L.C., 2003: Presence of aflatoxin M1 in milk for human consumption in Argentina. Food Control 14, 31–34Google Scholar
  239. 239.
    MAFF – UK, 1996: Survey of aflatoxin M1 in farm gate milk. Food-Surveillance-Information-Sheet No. 78Google Scholar
  240. 240.
    Martins, M.L., Martins, H.M., 2000: Aflatoxin M1 in raw and ultra high temperature-treated milk commercialized in Portugal. Food Additives and Contaminants 17, 871–874Google Scholar
  241. 241.
    Maxwell, S.M., Apeagyei, F., de Vries, H.R., Mwanmut, D.D., Hendrickse, R.G., 1989: Aflatoxins in breast milk, neonatal cord blood and sera of pregnant women. Journal of Toxicology – Toxin Reviews 8, 19–29Google Scholar
  242. 242.
    McKenzie, R.A., Blaney, B.J., Connole, M.D., Fitzpatrick, L.A., 1981: Acute aflatoxicosis in calves fed peanut hay. Australian Veterinary Journal 57, 284–286Google Scholar
  243. 243.
    Oruç, H.H., Sonal, S., 2001: Determination of aflatoxin M1 levels in cheese and milk consumed in Bursa, Turkey. Veterinary and Human Toxicology 43, 292–293Google Scholar
  244. 244.
    Polychronaki, N., Turner, P.C., Mykkänen, H., Gong, Y., Amra, H., Abdel-Wahhab, M., El-Nezami, H., 2006: Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers. Food Additives and Contaminants 23, 700–708Google Scholar
  245. 245.
    Rachelsperger, M., 1987: Essay about aflatoxin M1-content of drinking milk: summer/winter exposition. Ernährung/Nutrition 11, 248–249Google Scholar
  246. 246.
    Roussi, V., Govaris, A., Varagouli, A., Botsoglou, N.A., 2002: Occurrence of aflatoxin M1 in raw and market milk commercialized in Greece. Food Additives and Contaminants 19, 863–868Google Scholar
  247. 247.
    Saad, A.M., Abdelgadir, A.M., Moss, M.O., 1989: Aflatoxin in human and camel milk in Abu Dabi, United Arab Emirates. Mycotoxin Research 5, 57–60Google Scholar
  248. 248.
    Saad, A.M., Abdelgadir, A.M., Moss, M.O., 1995: Exposure of infants to aflatoxin M1 from mothers’ breast milk in Abu Dabi, UAE. Food Additives and Contaminants 12, 255–261Google Scholar
  249. 249.
    Sabino, M., Purchio, A., Milanez, T.V., 1996: Survey of aflatoxins B1, M1 and aflatoxicol in poultry and swine tissues from farms located in the states of Rio Grande Do Suland Santa Catarina, Brazil. Revista de Microbiologia 27, 189–191Google Scholar
  250. 250.
    Sabino, M., Purchio, A., Zorzetto, M.A.P., 1989: Variations in the levels of aflatoxin in cows milk consumed in the city of Sāo Paulo, Brazil. Food Additives and Contaminants 6, 321–326Google Scholar
  251. 251.
    Saitanu, K., 1997: Incidence of aflatoxin M1 in Thai milk products. Journal of Food Protection 60, 1010–1012Google Scholar
  252. 252.
    Salem, D.A., 2002: Natural occurrence of aflatoxins in feedstuffs and milk of dairy farms in Assiut Province, Egypt. Wiener Tierärztliche Monatsschrift 89, 86–91Google Scholar
  253. 253.
    Sassahara, M., Pontes Netto, D., Yanaka, E.K., 2005: Aflatoxin occurrence in foodstuff supplied to dairy cattle and aflatoxin M1 in raw milk in the north of Paraná State. Food and Chemical Toxicology 43, 981–984Google Scholar
  254. 254.
    Schuddeboom, L.J., 1983: Development of legislation concerning mycotoxins in dairy products in The Netherlands. Microbiologie – Aliments – Nutrition 1, 179–185Google Scholar
  255. 255.
    Srivastava, V.P., Bu-Abbas, A., Alaa-Basuny X, Al-Johar, W., Al-Mufti, S., Siddiqui, M.K.J., 2001: Aflatoxin M1 contamination in commercial samples of milk and dairy products in Kuwait. Food Additives and Contaminants 18, 993–997Google Scholar
  256. 256.
    Suzangar, M., Emami, A., Barnett, R., 1976: Aflatoxin contamination of village milk in Isfahan, Iran. Tropical Science 18, 155–159Google Scholar
  257. 257.
    Thirumala-Devi, K., Mayo, M.A., Hall, A.J., Craufurd, P.Q., Wheeler, T.R., Waliyar, F., Subrahmanyam, A., Reddy, D.V.R., 2002: Development and application of an indirect competitive enzyme-linked immunoassay for aflatoxin M1 in milk and milk-based confectionery. Journal of Agricultural and Food Chemistry 50, 933–937Google Scholar
  258. 258.
    Porter, J.K., Wray, E.M., Rimando, A.M., Stancel, P.C., Bacon, C.W., Voss, K.A., 1996: Lactational passage of fusaric acid from the feed of nursing dams to the neonate rat and effects on pineal neurochemistry in the F1 and F2 generations at weaning. Journal of Toxicology and Environmental Health 49, 161–175Google Scholar
  259. 259.
    Chao, T.-C., Maxwell, S.M., Wong, S.Y., 1991: An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: a clinicopathological study. Journal of Pathology 164, 225–233Google Scholar
  260. 260.
    Goeger, D.E., Shelton, D.W., Hendricks, J.D., Pereira, C., Bailey, G.S., 1988: Comparative effect of dietary butylated hydroxyanisole and ß-naphthoflavone on aflatoxin B1 metabolism, DNA adduct formation, and carcinogenesis in rainbow trout. Carcinogenesis 9, 1793–1800Google Scholar
  261. 261.
    Creppy, E.E., Betbeder, A.-M., Godin, M., Fillastre, J.-P., AMG, K.S., Simon, P., Lasseur, C., Combe, C., Aparicio, M., 1995: Ochratoxin A in human blood and chronic interstitial nephropathy: case report in France. Proceedings from 17. Mykotoxin-Workshop in der Bundesforschungsanstalt für Landwirtschaft, Braunschweig-Völkenrode 56–62Google Scholar
  262. 262.
    Ahmed, H., Hendrickse, R.G., Maxwell, S.M., Yakubu, A.M., 1995: Neonatal jaundice with reference to aflatoxins: an aetiological study in Zaria, northern Nigeria. Annals of Tropical Paediatrics 15, 11–20Google Scholar
  263. 263.
    Scheuer, R., Bernard, K., Leistner, L., 1984: Rückstände von Ochratoxin A in Schweinenieren. Mitteilungsblatt der Bundesanstalt für Fleischforschung 83, 5781–5784 [German]Google Scholar
  264. 265.
    Shepherd, E.C., Phillips, T.D., Rick Irvin, T., Safe, S.H., Robertson, L.W., 1984: Aflatoxin B1 metabolism in the rat: polyhalogenated biphenyl enhanced conversion to aflatoxin M1. Xenobiotica 14, 741–750Google Scholar
  265. 266.
    Patterson, D.S.P., Roberts, B.A., Small, B.J., 1976: Metabolism of ochratoxins A and B in the pig during early pregnancy and the accumulation in body tissues of ochratoxin A only. Food and Cosmetics Toxicology 14, 439–442Google Scholar
  266. 267.
    Shreeve, B.J., Patterson, D.S.P., Roberts, B.A., 1979: The „carry-over“of aflatoxin, ochratoxin and zearalenone from naturally contaminated feed to tissues, urine and milk of dairy cows. Food and Cosmetics Toxicology 17, 151–152Google Scholar
  267. 268.
    Miraglia, M., Brera, C., Cava, E., Calfapietra, F.R., 1998: The evaluation of major sources of ochratoxin A (OA) intake through the analysis of OA in biological fluids in Italy. Revue de Médicine Vétérinaire 149, 711Google Scholar
  268. 269.
    Olubuyide, I.O., Maxwell, S.M., Akinyinka, O.O., Hart, C.A., Neal, G.E., Hendrickse, R.G., 1993: HbsAg and aflatoxins in sera of rural (Igbo-Ora) and urban (Ibadan) populations in Nigeria. African Journal of Medicine and Medical Sciences 22, 77–80Google Scholar
  269. 270.
    Visconti, A., Bottalico, A., Solfrizzo, M., 1985: Aflatoxin M1 in milk, in southern Italy. Mycotoxin Research 1, 71–75Google Scholar
  270. 271.
    Wild, C.R., Pionneau, F.A., Montesano, R., Mutiro, C.F., Chetsanga, C.J., 1987: Aflatoxin detected in human breast milk by immunoassay. International Journal of Cancer 40, 328–333Google Scholar
  271. 272.
    Yadagiri, B., Tulpule, P.G., 1974: Aflatoxin in buffalo milk. Indian Journal of Dairy Science 27, 293–297Google Scholar
  272. 273.
    Zarba, A., Wild, C.P., Hall, A.J., Montesano, R., Hudson, G.J., Groopman, J.D., 1992: Aflatoxin M1 in human breast milk from The Gambia, West Africa, quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC. Carcinogenesis 13, 891–894Google Scholar
  273. 274.
    Hammer, P., Blüthgen, A., Walte, H.G., 1996: Carry-over of fumonisin B1 into the milk of lactating cows. Milchwissenschaft 51, 691–695Google Scholar
  274. 275.
    Maragos, C.M., Richard, J.L., 1994: Quantitation and stability of fumonisins B1 and B2 in milk. Journal of the Association of Official Analytical Chemists International 77, 1162–1167Google Scholar
  275. 276.
    Rice, L.G., Ross, P.F., 1994: Methods for detection and quantitation of fumonisins in corn, cereal products and animal excreta. Journal of Food Protection 57, 536–540Google Scholar
  276. 277.
    Hussain, I., Anwar, J., Munawar, M.A., Asi, M.R., 2008: Variation of levels of aflatoxin M1 in raw milk from different localities in the central areas of Punjab, Pakistan. Food Control 19, 1126–1129Google Scholar
  277. 278.
    Côté, L.-M., Dahlem, A.M., Yoshizawa, T., Swanson, S.P., Buck, W.B., 1986: Excretion of deoxynivalenol and its metabolite in milk, urine, and feces of lactating dairy cows. Journal of Dairy Science 69, 2416–2423Google Scholar
  278. 279.
    Steimer, J., Blüthgen, A., Heeschen, W., Wetzel, S., Hamann, J., 1990: Studies on the influence of aflatoxin M1-excretion by polychlorinated biphenyls in lactating cows. Kieler Milchwirtschaftliche Forschungsberichte 42, 543–552 [German]Google Scholar
  279. 280.
    Rizzi, L., Simioli, M., Roncada, P., Zaghini, A., 2003: Aflatoxin B1 and clinoptilolite in feed for laying hens: effects on egg quality, mycotoxin residues in livers, and hepatic mixed-function oxygenase activities. Journal of Food Protection 66, 860–865Google Scholar
  280. 281.
    Fukal, L., 1991: Spontaneous occurrence of ochratoxin A residues in Czechoslovak slaughter pigs determined by immunoassay. Deutsche Lebensmittel-Rundschau 87, 316–319Google Scholar
  281. 282.
    Smith, E.E., Phillips, T.D., Ellis, J.A., Harvey, R.B., Kubena, L.F., Thompson, J., Newton, G., 1994: Dietary hydrated sodium calcium aluminosilicate reduction of aflatoxin M1 residue in dietary goat milk and effects on milk production and components. Journal of Animal Science 72, 677–682Google Scholar
  282. 283.
    Höhler, D., Südekum, K.-H., Wolffram, S., Frohlich, A.A., Marquardt, R.R., 1999: Metabolism and excretion of ochratoxin A fed to sheep. Journal of Animal Science 77, 1217–1223Google Scholar
  283. 284.
    Prelusky, D.B., Veira, D.M., Trenholm, H.L., Foster, B.C., 1987: Metabolic fate and elimination in milk, urine and bile of deoxynivalenol following administration to lactating sheep. Journal of Environmental Science and Health B22, 125–148Google Scholar
  284. 285.
    Oyelami, O.A., Maxwell, S.M., Adelusola, K.A., Aladekoma, T.A., Oyelese, A.O., 1995: Aflatoxins in the autopsy brain tissue of children in Nigeria. Mycopathologia 132, 35–38Google Scholar
  285. 286.
    Chopra, R.C., Chhabra, A., Prasad, K.S.N., Dudhe, A., Murthy, T.N., Prasad, T., 1999: Carryover of aflatoxin M1 in milk of cows fed aflatoxin B1 contaminated ration. Indian Journal of Animal Nutrition 16, 103–106Google Scholar
  286. 287.
    Fukui, Y., Hoshino, K., Kameyama, Y., Yasui, T., Toda, C., Nagano, H., 1987: Placental transfer of ochratoxin A and its cytotoxic effect on the mouse embryo brain. Food and Chemical Toxicology 25, 17–24Google Scholar
  287. 288.
    Mirocha, C.J., Pawlowsky, R.A., Chatterjee, K., Watson, S., Hayes, W., 1983: Analysis for Fusarium toxins in various samples implicated in biological warfare in Southeast Asia. Journal of the Association of Official Analytical Chemists 66, 1485–1499Google Scholar
  288. 289.
    Anderson, P.H., Wells, G.A.H., Jackman, R., Morgan, M.R.A., 1984: Ochratoxicosis and ochratoxin residues in adult pig’s kidneys – a pilot study. In: Moss, M.O., Frank, M. (eds)., Proceedings of the 5th Meeting on Mycotoxins in Animal and Human Health, Meeting, pp 23–29. University of Edinburgh, Surrey Press, Guildford, UKGoogle Scholar
  289. 290.
    Apostolou, E., El-Nezami, H.S., Ahokas, J.T., Donohue, D.C., 1998: The evaluation of ochratoxin A in breast milk in Victoria (Australia). Revue de Médicine Vétérinaire 149, 709Google Scholar
  290. 291.
    Bauer, J., Gareis, M., 1987: Ochratoxin A in the food chain. Journal of Veterinary Medicine Series B 34, 613–627 [German]Google Scholar
  291. 292.
    Baumann, U., Zimmerli, B., 1988: A simple determination of ochratoxin A in foods. Mitteilungen aus dem Gebiete der Lebensmitteluntersuchung und Hygiene 79, 151–158 [German]Google Scholar
  292. 293.
    Breitholtz, A., Olsen, M., Dahlbäck, Ǻ, Hult, K., 1991: Plasma ochratoxin A levels in three Swedish populations surveyed using an ion-pair HPLC technique. Food Additives and Contaminants 8, 182–192Google Scholar
  293. 294.
    Breitholtz-Emanuelson, A., Olsen, M., Oskarsson, A., Palminger, I., Hult, K., 1993: Ochratoxin A in cow’s milk and in human milk with corresponding human blood samples. Journal of the Association of Official Analytical Chemists International 76, 842–846Google Scholar
  294. 295.
    Büchmann, N.B., Hald, B., 1985: Analysis, occurrence and control of ochratoxin A residues in Danish pig kidneys. Food Additives and Contaminants 2, 193–199Google Scholar
  295. 296.
    Dieber, F., Köfer, J., 1999: Ochratoxin A-Nachweis im Serum steirischer Schlachtschweine. Deutsche Lebensmittel-Rundschau 95, 327–329 [German]Google Scholar
  296. 297.
    Dragacci, S., Grosso, F., Bire, R., Fremy, J.M., Coulon, S., 1999: A French monitoring programme for determining ochratoxin A occurrence in pig kidneys. Natural Toxins 7, 167–173Google Scholar
  297. 298.
    Elling, F., Hald, B., Lacobsen, Chr., Krogh, P., 1975: Spontaneous toxic nephropathy in poultry associated with ochratoxin A. Pathologica et Microbiologica Scandinavica Section A 83, 739–741Google Scholar
  298. 299.
    Ferrufino-Guardia, E.V., Tangni, E.K., Larondelle, Y., Ponchaut, S., 2000: Transfer of ochratoxin A during lactation: exposure of suckling via the milk of rabbit does fed a naturally-contaminated feed. Food Additives and Contaminants 17, 167–175Google Scholar
  299. 300.
    Fukal, L., 1990: A survey of cereals, cereal products, feedstuffs and porcine kidneys for ochratoxin A by radioimmunoassay. Food Additives and Contaminants 7, 253–258Google Scholar
  300. 301.
    Gareis, M., Märtlbauer, E., Bauer, J., Gedek, B., 1988: Determination of ochratoxin A in human milk. Zeitschrift für Lebensmittel-Untersuchung und -Forschung 186, 114–117Google Scholar
  301. 302.
    Gareis, M., Rosner, H., Ehrhardt, S., 2000: Blood serum levels of ochratoxin A and nutrition habits. Archiv für Lebensmittelhygiene 51, 108–110Google Scholar
  302. 303.
    Goliński, P., Grabarkiewicz-Szczęsna, J., 1985: The first in Poland cases of detection of ochratoxin A residues in human blood. Roczniki Panstwowego Zakladu Higieny 36, 378–381 [Polish]Google Scholar
  303. 304.
    Goliński, P., Hult, K., Grabarkiewicz-Szczęsna, J., Chelkowski, J., Kneblewski, P., Szebiotko, K., 1984: Mycotoxic porcine nephropathy and spontaneous occurrence of ochratoxin A residues in kidneys and blood of Polish swine. Applied and Environmental Microbiology 47, 1210–1212Google Scholar
  304. 305.
    Goliński, P., Hult, K., Grabarkiewicz-Szczęsna, J., Chelkowski, J., Szebiotko, K., 1985: Spontaneous occurrence of ochratoxin A residues in porcine kidney and serum samples in Poland. Applied and Environmental Microbiology 49, 1014–1015Google Scholar
  305. 306.
    Hult, K., Hökby, E., Gatenbeck, S., Rutqvist, L., 1980: Ochratoxin A in blood from slaughter pigs in Sweden: use in evaluation of toxin content of consumed feed. Applied and Environmental Microbiology 39, 828–830Google Scholar
  306. 307.
    Langseth, W., Nymoen, U., Bergsjø, B., 1993: Ochratoxin A in plasma of Norwegian swine determined by an HPLC column-switching method. Natural Toxins 1, 216–221Google Scholar
  307. 308.
    Corley, R.A., Swanson, S.P., Buck, W.B., 1985: Glucuronide conjugates of T-2 toxin and metabolites in swine bile and urine. Journal of Agricultural and Food Chemistry 33, 1085–1089Google Scholar
  308. 309.
    Olsen, M., Malmlöf, K., Pettersson, H., Sandholm, K., Kiessling, K.-H., 1985: Plasma and urinary levels of zearalenone and α-zearalenol in a prepubertal gilt fed zearalenone. Acta Pharmacologica et Toxicologica 56, 239–243Google Scholar
  309. 310.
    Vinitketkumnuen, U., Chewonarin, T., Dhumtanom, P., Lertprasertsuk, N., Wild, C.P., 1999: Aflatoxin-albumin adduct formation after single and multiple doses of aflatoxin B1 in rats treated with Thai medicinal plants. Mutation Research 428, 345–351Google Scholar
  310. 311.
    Godin, M., Francois, A., le Roy, F., Morin, J.-P., Creppy, E., Hemet, J., Fillastre, J.-P., 1996: Karyomegalic interstitial nephritis. American Journal of Kidney Diseaes 27, 166Google Scholar
  311. 312.
    Breitholtz-Emanuelsson, A., Palminger-Hallén, I., Wohlin, P.O., Oskarsson, A., Hult, K., Olsen, M., 1993: Transfer of ochratoxin A from lactating rats to their offsprings: a short term study. Natural Toxins 1, 347–352Google Scholar
  312. 313.
    Dashwood, R.H., Arbogast, D.N., Fong, A.T., Hendricks, J.D., Bailey, G.S., 1988: Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1. Carcinogenesis 9, 427–432Google Scholar
  313. 314.
    Murthy, T.R.K., Jemmali, M., Henry, Y., Frayssinet, C., 1975: Aflatoxin residues in tissues of growing swine: effect of separate and mixed feeding of protein and protein-free portions of the diet. Journal of Animal Science 41, 1339–1347Google Scholar
  314. 315.
    Josefsson, A.E., 1979: Study of ochratoxin A in pig kidneys. Vår Föda 31, 415–420 [Swedish]Google Scholar
  315. 316.
    Frye, C.E., Chu, F.S., 1977: Distribution of ochratoxin A in chicken tissues and eggs. Journal of Food Safety 1, 147–159Google Scholar
  316. 317.
    Galtier, P., 1974: The fate of ochratoxin A in the animal organism. I. Transport of the toxin in the blood of the rat. Annales des Recherches Vétérinaires 5, 311–318 [French]Google Scholar
  317. 318.
    Robison, T.S., Mirocha, C.J., Kurtz, H.J., Behrens, J.C., Weaver, G.A., Chi, M.S., 1979: Distribution of tritium-labeled T-2 toxin in swine. Journal of Agricultural and Food Chemistry 27, 1411–1413Google Scholar
  318. 319.
    Hayes, J.R., Polan, C.E., Campbell, T.C., 1977: Bovine liver metabolism and tissue distribution of aflatoxin B1. Journal of Agricultural and Food Chemistry 25, 1189–1193Google Scholar
  319. 320.
    Lötzsch, R., Leistner, L., 1976: Aflatoxin residues in hen’s eggs and egg products. Fleischwirtschaft 56, 1777–1785 [German]Google Scholar
  320. 321.
    Jiang, Y., Jolly, P.E., Ellis, W.O., Wang, J.-S., Phillips, T.D., Williams, J.H., 2005: Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. International Immunology 17, 807–814Google Scholar
  321. 322.
    Hallén, I.P., Breitholz-Emanuelsson, A., Hult, K., Olsen, M., Oskarsson, A., 1998: Placental and lactational transfer of ochratoxin A in rats. Natural Toxins 6, 43–49Google Scholar
  322. 323.
    Hult, K., Pleština, R., Habazin-Novak, V., 1982: Ochratoxin A in human blood and Balkan endemic nephropathy. Archives of Toxicology 51, 313–321Google Scholar
  323. 324.
    Jørgensen, K., Petersen, A., 2002: Content of ochratoxin A in paired kidney and meat samples from healthy Danish slaughter pigs. Food Additives and Contaminants 19, 562–567Google Scholar
  324. 325.
    Köfer, J., Schuh, M., Fuchs, K., 1991: Ochratoxin A residues in Styrian slaughter pigs. Tierärztliche Umschau 46, 657–660 [German]Google Scholar
  325. 326.
    Kotowski, K., Grabarkiewicz-Szczęsna, J., Waskiewicz, A., Kostecki, M., Golinski, P., 2000: Ochratoxin A in porcine blood and in consumed feed samples. Mycotoxin Research 16, 66–72Google Scholar
  326. 327.
    Kotowski, K., Kostecki, M., Grabarkiewicz-Szczęsna, J., Golinski, P., 1993: Ochratoxin A residue in kidneys and blood of pigs. Medycyna Weterynaryjna 49, 554–556 [Polish]Google Scholar
  327. 328.
    Krogh, P., 1977: Ochratoxin A residues in tissues of slaughter pigs with nephropathy. Nordic Veterinary Medicine A 29, 402–405Google Scholar
  328. 329.
    Maaroufi, K., Achour, A., Betbeder, A.M., Hammami, M., Ellouz, F., Creppy, E.E., Bacha, H., 1995: Foodstuffs and human blood contamination by the mycotoxin ochratoxin A: correlation with chronic interstitial nephropathy in Tunisia. Archives of Toxicology 69, 552–558Google Scholar
  329. 330.
    Madsen, A., Hald, B., Lillehøj, E., Mortensen, H.P., 1982: Feeding experiments with ochratoxin A contaminated barley for bacon pigs. 2. Naturally contaminated barley given for 6 weeks from 20 kg compared with normal barley supplemented with crystalline ochratoxin A and/or citrinin. Acta Agriculturœ Scandinavica 32, 369–372Google Scholar
  330. 331.
    Ministry of the Agriculture, Fisheries and Foods (MAFF), 1993: Mycotoxins: Third report: 36th report of the steering group on chemical aspects of food surveillance (London: HSMO) pp. 39–44Google Scholar
  331. 332.
    Sadeghi, N., Oveisi, M.R., Jannat, B., Hajimahmoodi, M., Bonyani, H., Jannat, F., 2009: Incidence of aflatoxin M1 in human breast milk in Teheran, Iran. Food Control 20, 75–78Google Scholar
  332. 333.
    Majerus, P., Otteneder, H., Hower, C., 1989: Beitrag zum Vorkommen von Ochratoxin A in Schweineblutserum. Deutsche Lebensmittel-Rundschau 85, 307–313 [German]Google Scholar
  333. 334.
    Marquardt, R.R., Frohlich, A.A., Sreemannarayana, O., Abramson, D., Bernatsky, A., 1988: Ochratoxin A in blood from slaughter pigs in western Canada. Canadian Journal of Veterinary Research 52, 186–190Google Scholar
  334. 335.
    Morgan, M.R.A., McNerney, R., Chan, H.W.-S., Anderson, P.H., 1986: Ochratoxin A in pig kidney determined by enzyme-linked immunosorbent assay (ELISA). Journal of the Science of Food and Agriculture 37, 475–480Google Scholar
  335. 336.
    Mortensen, H.P., Hald, B., Larsen, A.E., Madsen, A., 1983: Ochratoxin A contaminated barley for sows and piglets. Pig performance and residues in milk and pigs. Acta Agriculturœ Scandinavica 33, 349–352Google Scholar
  336. 337.
    Olberg, I.H., Yndestad, M., 1982: A Norwegian survey of ochratoxin A in cereals and animal tissue. Nordisk Jordbruksforskning 64, 296Google Scholar
  337. 338.
    Ominski, K.H., Frohlich, A.A., Marquardt, R.R., Crow, G.H., Abramson, D., 1996: The incidence and distribution of ochratoxin A in western Canadian swine. Food Additives and Contaminants 13, 185–198Google Scholar
  338. 339.
    Pietri, A., Bertuzzi, T., Gualla, A., Piva, G., 2006: Occurrence of ochratoxin A in raw ham muscles and in pork products from nothern Italy. Italian Journal of Food Science 18, 99–106Google Scholar
  339. 340.
    Razzazi, E., Böhm, J., Grajewski, J., Szczepaniak, K., Kübber-Heiss, A.J., Iben, C.H., 2001: Residues of ochratoxin A in pet foods, canine and feline kidneys. Journal of Animal Physiology and Animal Nutrition 85, 212–216Google Scholar
  340. 341.
    Rosner, H., Rohrmann, B., Peiker, G., 2000: Ochratoxin A in human serum. Archiv für Lebensmittelhygiene 51, 104–107Google Scholar
  341. 342.
    Rousseau, D.M., Candlish, A.A.G., Slegers, G.A., van Peteghem, C.H., Stimson, W.H., Smith, J.E., 1987: Detection of ochratoxin A in porcine kidneys by a monoclonal antibody-based radioimmunoassay. Applied and Environmental Microbiology 53, 514–518Google Scholar
  342. 343.
    Rousseau, D.M., van Peteghem, C.H., 1989: Spontaneous occurrence of ochratoxin A residues in porcine kidneys in Belgium. Bulletin of Environmental Contamination and Toxicology 42, 181–186Google Scholar
  343. 344.
    Rutqvist, L., Björklund, N.-E., Hult, K., Gatenbeck, S., 1977: Spontaneous occurrence of ochratoxin residues in kidneys of fattening pigs. Zentralblatt für Veterinär Medizin A 24, 402–408Google Scholar
  344. 345.
    Scott, P.M., Kanhere, S.R., Lau, B.P.-Y., Lewis, D.A., Hayward, S., Ryan, J.J., Kuiper-Goodman, T., 1998: Survey of Canadian human blood plasma for ochratoxin A. Food Additives and Contaminants 15, 555–562Google Scholar
  345. 346.
    Skaug, M.A., Helland, I., Solvoll, K., Saugstad, O.D., 2001: Presence of ochratoxin A in human milk in relation to dietary intake. Food Additives and Contaminants 18, 321–327Google Scholar
  346. 347.
    Skaug, M.A., Størmer, F.C., Saugstad, O.D., 1998: Ochratoxin A: a naturally occurring mycotoxin found in human milk samples from Norway. Acta Pædiatrica 87, 1275–1278Google Scholar
  347. 348.
    Tyllinen, H., Hintikka, E.-L., 1982: Occurrence of ochratoxin A in swine kidneys and feed in Finland. Nordisk Jordbruksforskning 64, 298–299Google Scholar
  348. 349.
    Zimmerli, B., Dick, R., 1995: Determination of ochratoxin A at the ppt level in human blood, serum, milk and some foodstuffs by high-performance liquid chromatography with enhanced fluorescence detection and immunoaffinity column cleanup: methodology and Swiss data. Journal of Chromatography B, 666, 85–99Google Scholar
  349. 350.
    Curtui, V.G., Gareis, M., Usleber, E., Märtlbauer, E., 2001: Survey of Romanian slaughtered pigs for the occurrence of mycotoxins ochratoxins A and B, and zearalenone. Food Additives and Contaminants 18, 730–738Google Scholar
  350. 351.
    El-Sayed, A.M.A.A., Neamat-Allah, A.A., Soher, E.A., 2000: Situation of mycotoxins in milk, dairy products and human milk in Egypt. Mycotoxin Research 16, 91–100Google Scholar
  351. 352.
    El-Sayed, A.M.A.A., Soher, E.A., Neamat-Allah, A.A., 2002: Human exposure to mycotoxins in Egypt. Mycotoxin Research 18, 23–30Google Scholar
  352. 353.
    Fukal, L., Reisnerova, H., 1990: Monitoring of aflatoxins and ochratoxin A in Czechoslovak human sera by immunoassay. Bulletin of Environmental Contamination and Toxicology 44, 345–349Google Scholar
  353. 354.
    Jonsyn, F.E., Maxwell, S.M., Hendrickse, R.G., 1995: Ochratoxin A and aflatoxins in breast milk samples from Sierra Leone. Mycopathologia 131, 121–126Google Scholar
  354. 355.
    Navas, S.A., Sabino, M., Rodriguez-Amaya, D.B., 2005: Aflatoxin M1 and ochratoxin A in a human milk bank in the city of São Paulo, Brazil. Food Additives and Contaminants 22, 457–462Google Scholar
  355. 356.
    Turconi, G., Guarcello, M., Livieri, C., Comizolli, S., Maccarini, L., Castellazzi, A.M., Pietri, A., Piva, G., Roggi, C., 2004: Evaluation of xenobiotics in human milk and ingestion by the newborn. An epidemiological survey in Lombardy (Nothern Italy). European Journal of Nutrition 43, 191–197Google Scholar
  356. 357.
    Chen, C., Pearson, A.M., Coleman, T.H., Gray, J.I., Pestka, J.J., Aust, S.D., 1984: Tissue deposition and clearance of aflatoxins from broiler chickens fed a contaminated diet. Food and Chemical Toxicology 22, 447–451Google Scholar
  357. 358.
    Fernández, A., Belio, R., Ramos, J.J., Sanz, M.C., Sáez, T., 1997: Aflatoxins and their metabolites in the tissues, faeces and urine from lambs feeding on an aflatoxin-contaminated diet. Journal of the Science of Food and Agriculture 74, 161–168Google Scholar
  358. 359.
    Fernández, A., Verde, M.T., Gascón, M., Ramos, J.J., Gómez, J., 1994: Aflatoxin and its metabolites in tissues from laying hens and broiler chickens fed a contaminated diet. Journal of the Science of Food and Agriculture 65, 407–414Google Scholar
  359. 360.
    Okumura, H., Kawamura, O., Kishimoto, S., Hasegawa, A., Shrestha, S.M., Okuda, K., Obata, H., Okuda, H., Haruki, K., Uchida, T., Ogasawara, Y., Ueno, Y., 1993: Aflatoxin M1 in Nepalese sera, quantified by combination of monoclonal antibody immunoaffinity chromatography and enzyme-linked immunosorbent assay. Carcinogenesis 14, 1233–1235Google Scholar
  360. 361.
    Oliveira, C.A.F., Kobashigawa, E., Reis, T.A., Mestieri, L., Albuquerque, R., Corrêa, B., 2000: Aflatoxin B1 residues in eggs of laying hens fed a diet containing different levels of the mycotoxin. Food Additives and Contaminants 17, 459–462Google Scholar
  361. 362.
    Trucksess, M.W., Stoloff, L., Brumley, W.C., Wilson, D.M., Hale, O.M., Sangster, L.T., Miller, D.M., 1982: Aflatoxicol and aflatoxins B1 and M1 in the tissues of pigs receiving aflatoxin. Journal of the Association of Official Analytical Chemists 65, 884–887Google Scholar
  362. 363.
    Trucksess, M.W., Stoloff, L., Young, K., Wyatt, R.D., Miller, B.L., 1983: Aflatoxicol and aflatoxins B1 and M1 in eggs and tissues of laying hens consuming aflatoxin-contaminated feed. Poultry Science 62, 2176–2182Google Scholar
  363. 364.
    Valenta, H., Dänicke, S., Döll, S., 2003: Analysis of deoxynivalenol and de-epoxy-deoxynivalenol in animal tissues by liquid chromatography after clean-up with an immunoaffinity column. Mycotoxin Research 19, 51–55Google Scholar
  364. 365.
    Lusky, K., Tesch, D., Göbel, R., 1995: Untersuchung der Wirkung von natürlichem und kristallinem Ochratoxin A nach Verfütterung über 28 Tage beim Schwein mit anschließender Untersuchung des Rückstandsverhaltens beider Formen des Mykotoxins in Körperflüssigkeit und Organen sowie in Fleisch- und Wurstwaren. Archiv für Lebensmittelhygiene 46, 45–48 [German]Google Scholar
  365. 366.
    Lusky, K., Tesch, D., Göbel, R., Doberschütz, K.-D., 1994: Ochratoxin A. Untersuchungen zum Rückstandsverhalten beim Schwein und in daraus hergestellten Lebensmitteln. Fleisch-wirtschaft 74, 558–560 [German]Google Scholar
  366. 367.
    Dorner, J.W., Cole, R.J., Erlington, D.J., Suksupath, S., McDowell, G.H., Bryden, W.L., 1994: Cyclopiazonic acid residues in milk and eggs. Journal of Agricultural and Food Chemistry 42, 1516–1518Google Scholar
  367. 368.
    Belmadani, A., Tramu, G., Betbeder, A.M., Steyn, P.S., Creppy, E.E., 1998: Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain. Archives of Toxicology 72, 656–662Google Scholar
  368. 369.
    Razzazi, E., Böhm, J., Kettner, B., Hochsteiner, W., Kahlbacher, H., 2002: Metabolisierung von Deoxynivalenol beim Schwein: Bestimmung von DON und DOM-1 im Urin vom Schwein. Mycotoxin Research 18A, 84–88 [German]Google Scholar
  369. 370.
    Azcona-Olivera, J.I., Ouyang, Y., Murtha, J., Chu, F.S., Pestka, J.J., 1995: Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicology and Applied Pharmacology 133, 109–120Google Scholar
  370. 371.
    Hult, K., Rutquist, L., Holmberg, T., Thafvelin, B., Gatenbeck, S., 1984: Ochratoxin A in blood of slaughter pigs. Nordisk Veterinaermedicin 36, 314–316Google Scholar
  371. 372.
    Teleb, H.M., Fakhry, F.M., 1988: Aflatoxin B1 residue in broiler and its effect on fat metabolism. Veterinary Medical Journal 36, 135–145Google Scholar
  372. 373.
    Espada, Y., Guitart, R., Arboix, M., 1991: Quantitative determination of aflatoxin B1 in chick liver. Food Additives and Contaminants 8, 163–170Google Scholar
  373. 374.
    Bauer, J., Niemiec, J., Scholtyssek, S., 1988: Ochratoxin A in layers’ feed. 2. Report: residues in blood sera, livers and eggs. Archiv für Geflügelkunde 52, 71–75 [German]Google Scholar
  374. 375.
    Garaleviciene, D., Pettersson, H., Elwinger, K., 2002: Effects on health and blood plasma parameters of laying hens by pure nivalenol in the diet. Journal of Animal Physiology and Animal Nutrition 86, 389–398Google Scholar
  375. 376.
    Prior, M.G., O’Neil, J.B., Sisodia, C.S., 1980: Effects of ochratoxin A on growth response and residues in broilers. Poultry Science 59, 1254–1257Google Scholar
  376. 377.
    Lun, A.K., Young, L.G., Moran, Jr., E.T., Hunter, D.B., Rodriguez, J.P., 1986: Effects of feeding hens a high level of vomitoxin-contaminated corn on performance and tissue residues. Poultry Science 65, 1095–1099Google Scholar
  377. 378.
    Lusky, K., Göbel, R., Tesch, D., Tenner, G., Haider, W., Krüger, M., Lippert, A., 1998: Studies on the effects of ochratoxin A and deoxynivalenol toxicity on the health of pigs and tissue residue concentrations. Tierärztliche Umschau 53, 623–630 [German]Google Scholar
  378. 379.
    Kipper, L., Schweigmann, A., Vater, N., 1991: Studies of the carry-over of ochratoxin A within the line „animal food–pigs for slaughter–meat products“. Tierärztliche Umschau 46, 538–542 [German]Google Scholar
  379. 380.
    Lusky, K., Tesch, D., Göbel, R., Haider, W., 1997: Effects of OTA and ZEA on animal health and residue behaviour of pigs. Tierärztliche Umschau 52, 212–221 [German]Google Scholar
  380. 381.
    Wilkinson, A.P., Denning, D.W., Morgan, M.R.A., 1989: Immunoassay of aflatoxin in food and human tissue. Journal of Toxicology – Toxin Reviews 8, 69–79Google Scholar
  381. 382.
    Piskorska-Pliszczyńska, J., Juskiewicz, T., 1990: Tissue distribution and passage into eggs of ochratoxin A in Japanese quail. Journal of Environmental Pathology, Toxicology and Oncology 10, 8–10Google Scholar
  382. 383.
    Krogh, P., Elling, F., Gyrd-Hansen, N., Hald, B., Larsen, A.E., Lillehøj, E.B., Madsen, A., Mortensen, H.P., Ravnskov, U., 1976: Experimental porcine nephropathy: changes of renal function and structure perorally induced by crystalline ochratoxin A. Acta Pathologia Microbiologica Scandinavica Section A 84, 429–434Google Scholar
  383. 384.
    Bailey, G.S., Loveland, P.M., Pereira, C., Pierce, D., Hendricks, J.D., Groopman, J.D., 1994: Quantitative carcinogenesis and dosimetry in rainbow trout for aflatoxin B1 and aflatoxicol, two aflatoxins that form the same DNA adduct. Mutation Research 313, 25–38Google Scholar
  384. 385.
    Matsumoto, H., Ito, T., Ueno, Y., 1978: Toxicological approaches to the metabolites of Fusaria. XII. Fate and distribution of T-2 toxin in mice. Japanese Journal of Experimental Medicine 48, 393–399Google Scholar
  385. 386.
    Hald, B., 1991: Ochratoxin A in human blood in European countries. IARC Scientific Publications pp. 159–164Google Scholar
  386. 387.
    Brasel, T.L., Campbell, A.W., Demers, R.E., Ferguson, B.S., Fink, J., Vojdani, A., Wilson, S.C., Straus, D.C., 2004: Detection of trichothecene mycotoxins in sera from individuals exposed to Stachybotrys chartarum in indoor environments. Archives of Environmental Health 59, 317–323Google Scholar
  387. 388.
    Wang, J.-S., Huang, T., Su, J., Liang, F., Wei, Z., Liang, Y., Luo, H., Kuang, S.-Y., Qian, G.-S., Sun, G., He, X., Kensler, T.W., Groopman, J.D., 2001: Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People’s Republic of China. Cancer Epidemiology, Biomarkers & Prevention 10, 143–146Google Scholar
  388. 389.
    Pace, J.G., Watts, M.R., Burrows, E.P., Dinterman, R.E., Matson, C., Hauer, E.C., Wannemacher, Jr., R.W., 1985: Fate and distribution of 3H-labeled T-2 mycotoxin in guinea pigs. Toxicology and Applied Pharmacology 80, 377–385Google Scholar
  389. 390.
    Jonsyn, F.E., Maxwell, S.M., Hendrickse, R.G., 1995: Human fetal exposure to ochratoxin A and aflatoxins. Annals of Tropical Paediatrics 15, 3–9Google Scholar
  390. 391.
    Ueno, Y, Takai, Y., Baba, Y., 1990: Analysis of T-2 toxin metabolites in tissues and excreta of rats. Journal of Environmental Pathology, Toxicology and Oncology 10, 31–40Google Scholar
  391. 392.
    Sudhakar, B.V., 1992: The carry-over effect of aflatoxin B1 into eggs and liver of chicken. Indian Veterinary Journal 69, 1061–1062Google Scholar
  392. 393.
    Pepeljnjak, S., Blaževic, N., Čuljak, K., 1982: Histopathological changes and findings of ochratoxin A in organs of pigs, in the area of endemic nephropathy in Yugoslavia. Proceedings of the V. International Symposium on Mycotoxins and Phycotoxins, Vienna 346–348Google Scholar
  393. 394.
    Dailey, R.E., Reese, R.E., Brouwer, E.A., 1980: Metabolism of [14C]zearalenone in laying hens. Journal of Agricultural and Food Chemistry 28, 286–291Google Scholar
  394. 395.
    Solti, L., Pécsi, T., Barna-Vetró, I., Szasz, Jr., F., Biró, K, Szabó, E., 1999: Analysis of serum and seminal plasma after feeding ochratoxin A with breeding boars. Animal Reproduction Science 56, 123–132Google Scholar
  395. 396.
    Commission of the European Communities. Reports on tasks for scientific cooperation. Report of experts participating in task 3.2.2: assessment of dietary intake of ochratoxin A by the population in EU member states. Report EUR 17523 EN, 1997Google Scholar
  396. 397.
    Hoogenboom, L.A.P., Tulliez, J., Gautier, J.-P., Coker, R.D., Melcion, J.-P., Nagler, M.J., Polman, T.H.G., Delort-Laval, J., 2001: Absorption, distribution and excretion of aflatoxin-derived ammoniation products in lactating cows. Food Additives and Contaminants 18, 47–58Google Scholar
  397. 398.
    Yadav, A.S., Satija, K.C., Mahipal, S.K., 1995: Aflatoxin B1 deposition and clearance from tissues of broiler. Indian Journal of Poultry Science 30, 165–166Google Scholar
  398. 399.
    Colvin, B.M., Harrison, L.R., Gosser, H.S., Hall, R.F., 1984: Aflatoxicosis in feeder cattle. Journal of American Veterinary Association 184, 956–958Google Scholar
  399. 400.
    Reichmann, K.G., Blaney, B.J., Connor, J.K., Runge, B.M., 1982: The significance of aflatoxin and ochratoxin in the diet of Australian chickens. Australian Veterinary Journal 58, 211–212Google Scholar
  400. 401.
    Jonsyn-Ellis, F.E., 2000: Seasonal variation in exposure frequency and concentration levels of aflatoxins and ochratoxins in urine samples of boys and girls. Mycopathologia 152, 35–40Google Scholar
  401. 402.
    James, L.J., McGirr, L.G., Smith, T.K., 1982: High pressure liquid chromatography of zearalenone and zearenols in rat urine and liver. Journal of the Association of Official Analytical Chemists 65, 8–13Google Scholar
  402. 403.
    Beasley, V.R., Swanson, S.P., Corley, R.A., Buck, W.B., Koritz, G.D., Burmeister, H.R., 1986: Pharmacokinetics of the trichothecene mycotoxin, T-2 toxin, in swine and cattle. Toxicon 24, 13–23Google Scholar
  403. 404.
    Meyer, K., Usleber, E, Märtlbauer, E., Bauer, J., 2000: Occurrence of zearalenone, α- and β-zearalenol in biles of breeding sows in relation to the reproductive performance. Berliner und Münchener Tierärztliche Wochenschrift 113, 374–379 [German]Google Scholar
  404. 405.
    Loveland, P.M., Wilcox, J.S., Pawlowski, N.E., Bailey, G.S., 1987: Metabolism and DNA binding of aflatoxicol and aflatoxin B1 in vivo and in isolated hepatocytes from rainbow trout (Salmo gairdneri). Carcinogenesis 8, 1065–1070Google Scholar
  405. 406.
    Prelusky, D.B., Trenholm, H.L., 1992: Nonaccumulation of residues in swine tissue following extended consumption of deoxynivalenol-contaminated diets. Journal of Food Science 57, 801–802Google Scholar
  406. 407.
    Prelusky, D.B., Trenholm, H.L., 1991: Tissue distribution of deoxynivalenol in swine dosed intravenously. Journal of Agricultural and Food Chemistry 39, 748–751Google Scholar
  407. 408.
    Barel, S., Yagen, B., Bialer, M., 1990: Pharmacokinetics of the trichothecene mycotoxin verrucarol in dogs. Journal of Pharmaceutical Sciences 79, 548–551Google Scholar
  408. 409.
    Tesch, D., Lusky, K., 1993: Untersuchungen zum Einfluß des Mykotoxins Ochratoxin A auf die Tiergesundheit und auf das Rückstandsverhalten beim Schwein. Archiv für Lebensmittelhygiene 44, 77–80 [German]Google Scholar
  409. 410.
    Rousseau, D.M., Slegers, G.A., van Peteghem, C.H., 1986: Solid-phase radioimmunoassay of ochratoxin A in serum. Journal of Agricultural and Food Chemistry 34, 862–865Google Scholar
  410. 411.
    Holmberg, T., Breitholz, A., Bengtsson, A., Hult, K., 1990: Ochratoxin A in swine blood in relation to moisture content in feeding barley at harvest. Acta Agriculturae Scandinavica 40, 201–204Google Scholar
  411. 412.
    Tomaszewski, J., Miturski, R., Semezuk, A., Kotarski, J., Jakowicki, J., 1998: Tissue zearalenone concentrations in normal, hyperplastic and neoplastic human endometrium. Ginkologia Polska 69, 363–366 [Polish]Google Scholar
  412. 413.
    Dänicke, S., Valenta, H., Döll, S., 2004: On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Archives of Animal Nutrition 58, 169–180Google Scholar
  413. 414.
    Sypecka, Z., Kelly, M., Brereton, P., 2004: Deoxynivalenol and zearalenone residues in eggs of laying hens fed with a naturally contaminated diet: effects on egg production and estimation of transmission rates from feed to eggs. Journal of Agricultural and Food Chemistry 52, 5463–5471Google Scholar
  414. 415.
    Meky, F.A., Turner, P.C., Ashcroft, A.E., Miller, J.D., Qiao, Y.-L., Roth, M.J., Wild, C.P., 2003: Development of a urinary biomarker of human exposure to deoxynivalenol. Food and Chemical Toxicology 41, 265–273Google Scholar
  415. 416.
    Eriksen, G.S., Pettersson, H., Lindberg, J.E., 2003: Absorption, metabolism and excretion of 3-acetyl DON in pigs. Archives of Animal Nutrition 57, 335–345Google Scholar
  416. 417.
    Turner, P.C., Rothwell, J.A., White, K.L.M., Gong, Y.Y., Cade, J.E., Wild, C.P., 2008: Urinary deoxynivalenol is correlated with cereal intake in individuals from the United Kingdom. Environmental Health Perspectives 116, 21–25Google Scholar
  417. 418.
    Obremski, K., Gajęcki, M., Zwierzchowski, W., Bakula, T., Apoznański, J., Wojciechowski, J., 2003: The level of zearalenone and α-zearalenol in the blood of gilts with clinical symptoms of toxicosis, fed diets with a low zearalenone content. Journal of Animal and Feed Sciences 12, 529–538Google Scholar
  418. 419.
    Stoev, S.D., Vitanov, S., Anguelov, G., Petkova-Bocharova, T., Creppy, E.E., 2001: Experimental mycotoxic nephropathy in pigs provoked by a diet containing ochratoxin A and penicillic acid. Veterinary Research Communications 25, 205–223Google Scholar
  419. 420.
    Turner, P.C., Collison, A.C., Cheung, Y.B., Gong, Y.Y., Hall, A.J., Prentice, A.M., Wild, C.P., 2007: Aflatoxin exposure in utero causes growth faltering in Gambian infants. International Journal of Epidemiology 36, 1119–1125Google Scholar
  420. 421.
    Bauer, J., Bollwahn, W., Gareis, M., Gedek, B., Heinritzi, K., 1985: Kinetic profiles of diacetoxyscirpenol and two of its metabolites in blood serum of pigs. Applied and Environmental Microbiology 49, 842–845Google Scholar
  421. 422.
    Farnworth, E.R., Trenholm, H.L., 1983: The metabolism of the mycotoxin zearalenone and its effects on the reproductive tratcts of young male and female pigs. Canadian Journal of Animal Science 63, 967–975Google Scholar
  422. 423.
    Prelusky, D.B., Trenholm, H.L., Hamilton, R.M.G., Miller, J.D., 1987: Transmission of [14C]deoxynivalenol to eggs following oral administration to laying hens. Journal of Agricultural and Food Chemistry 35, 182–186Google Scholar
  423. 424.
    Prelusky, D.B., Hamilton, R.M.G., Trenholm, H.L., 1989: Transmission of residues to eggs following long-term administration of 14C-labelled deoxynivalenol to laying hens. Poultry Science 68, 744–748Google Scholar
  424. 425.
    Corley, R.A., Swanson, S.P., Gullo, G.J., Johnson, L., Beasley, V.R., Buck, W.B., 1986: Disposition of T-2 toxin, a trichothecene mycotoxin, in intravascularly dosed swine. Journal of Agricultural and Food Chemistry 34, 868–875Google Scholar
  425. 426.
    Manique, R., Pena, A., Lino, C.M., Moltó, J.C., Maňes, J., 2008: Ochratoxin A in the morning and afternoon portions of urine from Coimbra and Valencian populations. Toxicon 51, 1281–1287Google Scholar
  426. 427.
    McCoy, L.F., Scholl, P.F., Sutcliffe, A.E., Kieszak, S.M., Powers, C.D., Rogers, H.S., Gong, Y.Y., Groopman, J.D., Wild, C.P., Schleicher, R.L., 2008: Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detectection, and HPLC with isotope dilution mass spectrometry. Cancer Epidemiology, Biomarkers & Prevention 17, 1653–1657Google Scholar
  427. 428.
    Abdulrazzaq, Y.M., Osman, N., Yousif, Z.M., Trad, O., 2004: Morbidity in neonates of mothers who have ingested aflatoxins. Annals of Tropical Paediatrics 24, 145–151Google Scholar
  428. 429.
    Assaf, H., Betbeder, A.-M., Creppy, E.E., Pallardy, M., Azouri, H., 2004: Ochratoxin A levels in human plasma and foods in Lebanon. Human & Experimental Toxicology 23, 495–501Google Scholar
  429. 430.
    Bammler, T.K., Slone, D.H., Eaton, D.L., 2000: Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates. Toxicological Science 54, 30–41Google Scholar
  430. 431.
    Losito, I., Monaci, L., Palmisano, F., Tantillo, G., 2004: Determination of ochratoxin A in meat products by high-performance liquid chromatography coupled to electrospray ionisation sequential mass spectrometry. Rapid Communications in Mass Spectrometry 18, 1965–1971Google Scholar
  431. 432.
    Gajęcki, M, Przybylowicz, M., Zielonka, L., Zwierzchowski, W., Obremski, K., Skorska-Wyszyńska, E., Gajęcka, M., Polak, M., Jakimiuk, E., 2004: Preliminary results of monitoring research on zearalenone presence in blood of women with neoplastic lesions in reproductive system. Polish Journal of Veterinary Sciences 7, 153–156Google Scholar
  432. 433.
    Zarba, A., Hmieleski, R., Hemenway, D.R., Jakab, G.J., Groopman, J.D., 1992: Aflatoxin B1-DNA adduct formation in rat liver following exposure by aerosol inhalation. Carcinogenesis 13, 1031–1033Google Scholar
  433. 434.
    Lopez, C., Ramos, L., Bulacio, L., Ramadan, S., Rodriguez, F., 2002: Aflatoxin B1 content in patients with hepatic diseases. MEDICINA (Buenos Aires) 62, 313–316Google Scholar
  434. 435.
    Autrup, J.L., Schmidt, J., Autrup, H., 1993: Exposure to aflatoxin B1 in animal-feed production plant workers. Environmental Health Perspectives 99, 195–197Google Scholar
  435. 436.
    Sewram, V., Mshicileli, N., Shephard, G.S., Marasas, W.F.O., 2003: Fumonisin mycotoxins in human hair. Biomarkers 8, 110–118Google Scholar
  436. 437.
    Nayak, S., Sashidhar, R.B., Bhat, R.V., 2001: Quantification and validation of enzyme immunoassay for urinary aflatoxin B1-N 7-guanine adduct for biological monitoring of aflatoxins. Analyst 126, 179–183Google Scholar
  437. 438.
    Sangare-Tigori, B., Moukha, S., Kouadio, J.H., Dano, D.S., Betbeder, A.-M., Achour, A., Creppy, E.E., 2006: Ochratoxin A in human blood in Abidjan, Côte d’Ivoire. Toxicon 47, 894–900Google Scholar
  438. 439.
    Vettorazzi, A., Gonzales-Peňas, E., Arbillagra, L., Corcuera, L.-A., López de Cerain, A., 2008: Simple high-performance liquid chromatography-fluorescence detection method for plasma, kidney and liver of rats as a tool for toxicological studies. Journal of Chromatography A 1215, 100–106Google Scholar
  439. 440.
    Skaug, M.A., 2003: Levels of ochratoxin A and IGG against conidia of Penicillium verruculosum in blood samples from healthy farm workers. Annals of Agricultural and Environmental Medicine 10, 73–77Google Scholar
  440. 441.
    Monaci, L., Tantillo, G., Palmisano, F., 2004: Determination of ochratoxin A in pig tissues by liquid-liquid extraction and clean-up and high-performance liquid chromatography. Analytical and Bioanalytical Chemistry 378, 1777–1782Google Scholar
  441. 442.
    Turner, P.C., Burley, V.J., Rothwell, J.A., White, K.L.M., Cade, J.E., Wild, C.P., 2008: Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adults. Journal of Exposure Science and Environmental Epidemiology 18, 392–399Google Scholar
  442. 443.
    Ibeh, I.N., Uraih, N., Ogonar, J.I., 1994: Dietary exposure to aflatoxin in human male infertility in Benin City, Nigeria. International Journal of Fertility and Menopausal Studies 39, 208–214Google Scholar
  443. 444.
    Chao, T.C., Lo, D., Bloodworth, B., Gunasegaram, R., Koh, T., Ng, H., 1994: Aflatoxin exposure in Singapore: blood aflatoxin levels in normal subjects, hepatitis B virus carriers and primary hepatocellular carcinoma patients. Medicine, Science and the Law 34, 289–298Google Scholar
  444. 445.
    Mehta, R., Laver, G.W., Stapley, R., McMullen, E., 1992: Liver DNA adducts in methyl-deficient rats administered a single dose of aflatoxin B1. Carcinogenesis 13, 1241–1247Google Scholar
  445. 446.
    Postupolski, J., Karlowski, K., Kubik, P., 2006: Ochratoxin A in maternal and foetal blood and in maternal milk. Roczniki Panstwowego Zaklado Higieny 57, 23–30Google Scholar
  446. 447.
    Hatem, N.L., Hassab, H.M.A., Abd Al-Rahman, E.M., El-Deeb, S.A., El-Sayed Ahmed, R.L., 2005: Prevalence of aflatoxins in blood and urine of Egyptian infants with protein-energy malnutrition. Food and Nutrition Bulletin 26, 49–56Google Scholar
  447. 448.
    Egner, P.A., Groopman, J.D., Wang, J.-S., Kensler, T., Friesen, M.D., 2006: Quantification of aflatoxin-B1-N 7-guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chemical Research in Toxicology 19, 1191–1195Google Scholar
  448. 449.
    Hassan, A.M., Sheashaa, H.A., Fattah, M.F.A., Ibrahim, A.Z., Gaber, O.A., Sobh, M.A., 2006: Study of ochratoxin A as an environmental risk that causes renal injury in breast-fed Egyptian infants. Pediatric Nephrology 21, 102–105Google Scholar
  449. 450.
    Dostal, A., Jakusova, L., Cajdova, J., Hudeckova, H., 2008: Results of the first studies of occurrence of ochratoxin A in human milk in Slovakia. Bratislavslec Lekarske Listy 109, 276–278Google Scholar
  450. 451.
    Tang, L., Tang, M., Xu, L., Luo, H., Huang, T., Yu, J., Zhang, L., Gao, W., Cox, S.B., Wang, J.-S., 2008: Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention. Carcinogenesis 29, 411–417Google Scholar
  451. 452.
    Tajik, H., Rohani, S.M.R., Moradi, M., 2007: Detection of aflatoxin M1 in raw and commercial pasteurized milk in Urmia, Iran. Pakistan Journal of Biological Sciences 10, 4103–4107Google Scholar
  452. 453.
    Sefidgar, S.A.A., Azizi, G., Khosravi, A.R., Roudbar-Mohammadi, S., 2008: Presence of aflatoxin M1 in raw milk at cattle farms in Babol, Iran. Pakistan Journal of Biological Science 11, 484–486Google Scholar
  453. 454.
    Shundo, L., Sabino, M., 2006: Aflatoxin M1 in milk by immunoaffinity column cleanup with TLC/HPLC determination. Brazilian Journal of Microbiology 37, 164–167Google Scholar
  454. 455.
    Mokhles, M., Abdl El Wahhab, M.A., Tawfik, M., Ezzat, W., Gamil, K., Ibrahim, M., 2007: Detection of aflatoxin among hepatocellular carcinoma patients in Egypt. Pakistan Journal of Biological Science 10, 1422–1429Google Scholar
  455. 456.
    Duarte, S., Bento, J., Pena, A., Lino, C.M., Delerue-Matos, C., Oliva-Teles, T., Morais, S., Correira, M., Oliveira, M.B.P.P., Alves, M.R., Pereira, J.A., 2010: Monitoring of ochratoxin A exposure of the Portuguese population through a nationwide urine survey – Winter 2007. Science of the Total Environment 408, 1195–1198Google Scholar
  456. 457.
    Jolly, P., Jiang, Y., Ellis, W., Awuah, R., Nnedu, O., Phillips, T., Wang, J.-S., Afriyie-Gyawu, E., Tang, L., Persom, S., Williams, J., Jolly, C., 2006: Determinants of aflatoxin levels in Ghanaians: sociodemographic factors, knowledge of aflatoxin and food handling and consumption practices. International Journal of Hygiene and Environmental Health 209, 345–358Google Scholar
  457. 458.
    Abulu, E.O., Uriah, N., Aigbefo, H.S., Oboh, P.A., Agbonlahor, D.E., 1998: Preliminary investigation on aflatoxin in cord blood of jaundiced neonates. West African Journal of Medicine 17, 184–187Google Scholar
  458. 459.
    Matsumura, M., Mori, T., 1998: Detection of aflatoxins in autopsied materials from a patient infected with Aspergillus flavus. Nippon Ishinkin Gakkai Zasshi 39, 167–171Google Scholar
  459. 460.
    Denning, D.W., Quiepo, S.C., Altman, D.G., Makarananda, K., Neal, G.E., Camallerre, E.L., Morgan, M.R.A., Tupasi, T.E., 1995: Aflatoxin and outcome from acute lower respiratory infection in children in The Phillippines. Annals of Tropical Peadiatrics 15, 209–216Google Scholar
  460. 461.
    Ankrah, N.A., Rikimaru, T., Ekuban, F.A., 1994: Observations on aflatoxins and the liver status of Ghanaian subjects. East African Medical Journal 71, 739–741Google Scholar
  461. 462.
    Liu, Z.-H., Tu, W.-S., Li, D.-R.O, Li, Y.-D., Xie, C.-H., Yang, Y.Z., Qin, B.-B., 1990: A new method for the quantitation of aflatoxin M1 in urine by high performance liquid chromatography and its application to the etiologic study of hepatoma. Biomedical Chromatography 4, 83–86Google Scholar
  462. 463.
    Chelule, P.K., Gqaleni, N., Chuturgoon, A.A., Dutton, M.F., 2000: The determination of fumonisin B1 in human faeces: a short term marker for assessment of exposure. Biomarkers 5, 1–8Google Scholar
  463. 464.
    Castegnaro, M., Maru, V., Petkova-Bocharova, T., Nikolov, I., Bartsch, H., 1991: Concentrations of ochratoxin A in the urine of endemic nephropathy patients and controls in Bulgaria: lack of detection of 4-hydroxyochratoxin A. In: Castegnaro, R., Dirheimer, G., Chernozemsky, I.N., Bartsch, H. (eds). Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Lyon, International Agency for Research on Cancer, IARC, pp.165–169Google Scholar
  464. 465.
    Cusumano, V., 1991: Aflatoxins in sera from patients with lung cancer. Oncology 48, 194–195Google Scholar
  465. 466.
    de Vries, H.R., Lamplugh, S.M., 1989: Aflatoxins in liver biopsies from Kenya. Tropical and Geographical Medicine 41, 26–30Google Scholar
  466. 467.
    Abdulrazzaq, Y.M., Osman, N., Ibrahim, A., 2002: Fetal exposure to aflatoxins in the United Arab Emirates. Annals of Tropical Paediatrics 22, 3–9Google Scholar
  467. 468.
    Dinis, A.M.P., Lino, C.M., Pena, A.S., 2007: Ochratoxin A in nephropathic patients from two cities of central zone in Portugal. Pharmaceutical and Biomedical Analysis 44, 553–557Google Scholar
  468. 469.
    Dänicke, S., Ueberschär, K.-H., Valenta, H., Matthes, S., Matthäus, K., Halle, I., 2004: Effects of graded levels of Fusarium-toxin-contaminated wheat in Pekin duck diets on performance, health and metabolism of deoxynivalenol and zearalenone. British Poultry Science 45, 264–272Google Scholar
  469. 470.
    Iavicoli, I., Brera, C., Carelli, G., Caputi, R., Marinaccio, A., Miraglia, M., 2002: External and internal dose in subjects occupationally exposed to ochratoxin A. International Archives of Occupational and Environmental Health 75, 381–386Google Scholar
  470. 471.
    Newman, S.J., Smith, J.R., Stenske, K.A., Newman, L.B., Dunlap, J.R., Imerman, P.M., Kirk, C.A., 2007: Aflatoxicosis in nine dogs after exposure to contaminated commercial dog food. Journal of Veterinary Diagnostic Investigation 19, 168–175Google Scholar
  471. 472.
    Fazekas, B., Tar, A., Kovács, M., 2005: Ochratoxin A content of urine samples of healthy humans in Hungary. Acta Veterinaria Hungarica 53, 35–44Google Scholar
  472. 473.
    Biró, K., Solti, L., Barna-Vetró, I., Bagó, G., Glávits, R., Szabó, E., Fink-Gremmels, J., 2002: Tissue distribution of ochratoxin A as determined by HPLC and ELISA and histopathological effects in chickens. Avian Pathology 31, 141–148Google Scholar
  473. 474.
    Poapolathep, A., Poapolathep, S., Sugita-Konishi, Y., Imsilp, K., Tassanawat, T., Sinthusing, C., Itoh, Y., Kumagai, S., 2008: Fate of fusarenon-X in broilers and ducks. Poultry Science 87, 1510–1515Google Scholar
  474. 475.
    Schneweis, I., Meyer, K., Ritzmann, M., Hoffmann, P., Dempfle, L., Bauer, J., 2005: Influence of organically or conventionally produced wheat on health, performance and mycotoxin residues in tissues and bile of growing pigs. Archives of Animal Nutrition 59, 155–163Google Scholar
  475. 476.
    Battacone, G., Nudda, A., Cannas, A., Cappio Borlino, A, Bomboi, G., Pulina, G., 2003: Excretion of aflatoxin M1 in milk of dairy ewes treated with different doses of aflatoxin B1. Journal of Dairy Science 86, 2667–2675Google Scholar
  476. 477.
    Battacone, G., Nudda, A., Palomba, M., Pascale, M., Nicolussi, P., Pulina, G., 2005: Transfer of aflatoxin B1 from feed to milk and from milk to curd and whey in dairy sheep fed artificially contaminated concentrates. Journal of Dairy Science 88, 3063–3069Google Scholar
  477. 478.
    Boudra, H., Barnouin, J., Dragacci, S., Morgavi, D.P., 2007: Aflatoxin M1 and ochratoxin A in raw bulk milk from French dairy herds. Journal of Dairy Science 90, 3197–3201Google Scholar
  478. 479.
    Tajkarimi, M., Shojaee Aliabadi, F., Salah Nejad, M., Pursoltani, H., Motallebi, A.A., Mahdavi, H., 2007: Seasonal study of aflatoxin M1 contamination in milk in five regions in Iran. International Journal of Food Microbiology 116, 346–349Google Scholar
  479. 480.
    Tardieu, D., Bailly, J.-D., Skiba, F., Grosjean, F., Guerre, P., 2008: Toxicokinetics of fumonisin B1 in turkey poults and tissue persistence after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds. Food and Chemical Toxicology 46, 3213–3218Google Scholar
  480. 481.
    Polychronaki, N., Wild, C.P., Mykkänen, H., Amra, H., Abdel-Wahhab, M., Sylla, A., Diallo, M., El-Nezami, H., Turner, P.C., 2008: Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea. Food and Chemical Toxicology 46, 519–526Google Scholar
  481. 482.
    Blank, R., Rolfs, J.-P., Südekum, K.-H., Frohlich, A.A., Marquadt, R.R., Wolffram, S., 2003: Effects of chronic ingestion of ochratoxin A on blood levels and excretion of the mycotoxin in sheep. Journal of Agricultural and Food Chemistry 51, 6899–6905Google Scholar
  482. 483.
    Döll, S., Dänicke, S, Valenta, H., 2008: Residues of deoxynivalenol (DON) in pig tissue after feeding mash or pellet diets containing low concentrations. Molecular Nutrition & Food Research 52, 727–734Google Scholar
  483. 484.
    Dänicke, S., Valenta, H., Klobasa, F., Döll, S., Ganter, M., Flachowsky, G., 2004: Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Archives of Animal Nutrition 58, 1–17Google Scholar
  484. 485.
    Ahsan, H., Wang, L.-Y., Chen, C.-J., Tsai, W.-Y., Santella, R.M., 2001: Variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C Virus infection and glutathione S-transferase M1 and T1 genotype. Environmental Health Perspectives 109, 833–837Google Scholar
  485. 486.
    Chen, S.-Y., Chen, C.-J., Chou, S.-R., Hsieh, L.-L., Wang, L.-Y., Tsai, W.-Y., Ahsan, H., Santella, R.M., 2001: Association of aflatoxin B1-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan. Cancer Epidemiology, Biomarkers & Prevention 10, 1223–1226Google Scholar
  486. 487.
    Yagen, B., Bialer, B., Sintov, A., 1985: Gas chromatographic assay with pharmacokinetic applications for monitoring T-2 and HT-2 toxins in plasma. Journal of Chromatography 343, 67–75Google Scholar
  487. 488.
    Gong, Y., Hounsa, A., Egal, S., Turner, P.C., Sutcliffe, A.E., Hall, A.J., Cardwell, K., Wild, C.P., 2004: Postweaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Aftrica. Environmental Health Perspectives 112, 1334–1338Google Scholar
  488. 489.
    Campbell, T.C., Hayes, J.R., Newberne, P.M., 1978: Dietary lipotropes, hepatic microsomal mixed-function oxidase activities, and in vivo covalent binding of aflatoxin B1 in rats. Cancer Research 38, 4569–4573Google Scholar
  489. 490.
    Schrager, T.F., Newberne, P.M., Pikul, A.H., Groopman, J.D., 1990: Aflatoxin-DNA adduct formation in chronically dosed rats fed a choline-deficient diet. Carcinogenesis 11, 177–180Google Scholar
  490. 491.
    Micco, C., Miraglia, M., Onori, R., Libanori, A., Brera, C., Mantovani, A.L., Macrì, C., 1991: Effects of combined exposure to ochratoxin A and penicillic acid on residues and toxicity in broilers. La Revista della Società Italiana di Scienza dell’Alimentazione 20, 101–108Google Scholar
  491. 492.
    Qin, G., Gopalan-Kriczky, P., Su, J., Ning, Y., Lotlikar, P.D., 1997: Inhibition of aflatoxin B1-induced initiation of hepatocarcinogenesis in the rat by green tea. Cancer Letters 112, 149–154Google Scholar
  492. 493.
    Tang, L., Guan, H, Ding, X., Wang, J.-S., 2007: Modulation of aflatoxin toxicity and biomarkers by lycopene in F344 rats. Toxicology and Applied Pharmacology 219, 10–17Google Scholar
  493. 494.
    Pestka, J.J., Islam, Z., Amuzie, C.J., 2008: Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicology Letters 178, 83–87Google Scholar
  494. 495.
    Egner, P.A., Wang, J.-B., Zhu, Y.-R., Zhang, B.-C., Wu, Y., Zhang, Q.-N., Qian, G.-S., Kuang, S.-Y., Gange, S. J., Jacobson, L.P., Helzsouer, K.J., Bailey, G.S., Groopman, J.D., Kensler, T.W., 2001: Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proceedings of the National Academy of Science 98, 14601–14606Google Scholar
  495. 496.
    Guan, R., Oon, C.J., Wild, C., Motesano, R., 1986: A preliminary survey on aflatoxin exposure in Singapore. Annals Academy of Medicine 15, 201–205Google Scholar
  496. 497.
    Mirocha, C.J., Pawlosky, R.J., Chatterjee, K., 1984: Analytical methodology, detection of trichothecenes from Southeast Asia samples and their residues in animal tissue. Archives Belges Supplement, 210–218Google Scholar
  497. 498.
    Heyndrickx, A., Sookvanichsilp, N., van den Heede, M., 1984: Detection of trichothecene mycotoxins (Yellow Rain) in blood, urine and faeces of Iranian soldiers treated as victims of a gas attack. Archives Belges Supplement, 143–146Google Scholar
  498. 499.
    Pang, V.F., Swanson, S.P., Beasley, V.R., Buck, W.B., Haschek, W.M., 1987: The toxicity of T-2 toxin in swine following topical application. I. Clinical signs, pathology, and residue concentrations. Fundamental and Applied Toxicology 9, 41–49Google Scholar
  499. 500.
    Naudé, T.W., O’Brien, O.M., Rundberget, T., Mc Gregor, A.D.G., Roux, C., Flåøyen, A., 2002: Tremorgenic neuromycotoxicosis in 2 dogs ascribed to the ingestion of penitrem A and possibly roquefortine in rice contaminated with Penicillium crustosum. Journal of the South African Veterinary Association 73, 211–215Google Scholar
  500. 501.
    Hedman, R., Pettersson, H., Lindberg, J.E., 1997: Absorption and metabolism of nivalenol in pigs. Archives of Animal Nutrition 50, 13–24Google Scholar
  501. 502.
    Pacin, A.M., Ciancio Bovier, E.V., Motta, E., Resnik, S.L., Villa, D., Olsen, M., 2008: Survey of Argentinean human plasma for ochratoxin A. Food Additives and Contaminants 25, 635–641Google Scholar
  502. 503.
    Turner, P.C., Loffredo, C., El Kafrawy, S., Ezzat, S., Abdel Latif Eissa, S., El Daly, M., Nada, O., Abdel-Hamid, M., 2008: Pilot survey of aflatoxin-albumin adducts in sera from Egypt. Food Additives and Contaminants 25, 583–587Google Scholar
  503. 504.
    Muňoz, K., Vega, M., Rios, G., Muňoz, S., Madariaga, R., 2006: Preliminary study of ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption. Food and Chemical Toxicology 44, 1884–1889Google Scholar
  504. 505.
    Pena, A., Seifrtová, M., Lino, C., Silveira, I., Solich, P., 2006: Estimation of ochratoxin A in Portuguese population: new data on the occurrence in human urine by high performance liquid chromatography with fluorescence detection. Food and Chemical Toxicology 44, 1449–1454Google Scholar
  505. 506.
    Thuvander, A., Paulsen, J.E., Axberg, K., Johannson, N., Vidnes, A., Enghardt-Barbieri, H., Trygg, K., Lund-Larsen, K., Jahrl, S., Widenfalk, A., Bosnes, V., Alexander, J., Hult, K., Olsen, M., 2001: Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food and Chemical Toxicology 39, 1145–1151 (and personal communication)Google Scholar
  506. 507.
    Lino, C.M., Baeta, M.L., Henri, M., Dinis, A.M.P., Pena, A.S., Silveira, M.I.N., 2008: Levels of ochratoxin A in serum from urban and rural Portuguese populations and estimation of exposure degree. Food and Chemical Toxicology 46, 879–885Google Scholar
  507. 508.
    Commission of the European Communities, 2002. Reports on tasks for scientific cooperation. Report of experts participating in task 3.2.7: assessment of dietary intake of ochratoxin A by the population in EU member statesGoogle Scholar
  508. 509.
    Aoudia, N., Tangni, E.K., Larondelle, Y., 2008: Distribution of ochratoxin A in plasma and tissues of rat fed a naturally contaminated diet amended with micronized wheat fibres: effectiveness of mycotoxin sequestering activity. Food Chemical Toxicology 46, 871–878Google Scholar
  509. 510.
    Gong, Y.Y., Torres-Sanchez, L., Lopez-Carillo, L., He Peng, J., Sutcliffe, A.E., White, K.L., Humpf, H.-U., Turner, P.C., Wild, C.P., 2008: Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population. Cancer Epidemiology, Biomarkers & Prevention 17, 688–694Google Scholar
  510. 511.
    Monroe, D.H., Eaton, D.L., 1988: Effects of modulation of hepatic glutathione on biotransformation and covalent binding of aflatoxin B1 to DNA in the mouse. Toxicology and Applied Pharmacology 94, 118–127Google Scholar
  511. 512.
    Coppock, R.W., Swanson, S.P., Gelberg, H.B., Koritz, G.D., Buck, W.B., Hoffmann, W.E., 1987: Pharmacokinetics of diacetoxyscirpenol in cattle and swine: effects of halothane. American Journal of Veterinary Research 48, 691–695Google Scholar
  512. 513.
    Pascale, M., Visconti, A., 2000: Rapid method for the determination of ochratoxin A in urine by immunoaffinity column clean-up and high-performance liquid chromatography. Mycopathologia 152, 91–95Google Scholar
  513. 514.
    Elgerbi, A.M., Aidoo, K.E., Candlish, A.A.G., Tester, R.F., 2004: Occurrence of aflatoxin M1 in randomly selected North African milk and cheese samples. Food Additives and Contaminants 21, 592–597Google Scholar
  514. 515.
    Micco, C., Miraglia, M., Benelli, L., Onori, R., Ioppolo, A., Mantovani, A.L., 1988: Long term administration of low doses of mycotoxins in poultry. 2. Residues of ochratoxin A and aflatoxins in broilers and laying hens after combined administration of ochratoxin A and aflatoxin B1. Food Additives and Contaminants 5, 309–314Google Scholar
  515. 516.
    Plakas, S.M., Loveland, P.M., Bailey, G.S., Blazer, V.S., Wilson, G.L., 1991: Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in channel catfish. Food and Chemical Toxicology 29, 805–808Google Scholar
  516. 517.
    Wang, J.-S., Abubaker, S., He, X., Sun, G., Strickland, P.T., Groopman, J.D., 2001: Development of aflatoxin B1-lysine adduct monoclonal antibody for human exposure studies. Applied and Environmental Microbiology 67, 2712–2717Google Scholar
  517. 518.
    Kamkar, A., 2005: A study on the occurrence of aflatoxin M1 in raw milk produced in Sarab City of Iran. Food Control 16, 593–599Google Scholar
  518. 519.
    Honstead, J.P., Dreesen, D.W., Stubblefield, R.D., Shotwell, O.L., 1992: Aflatoxins in swine tissues during drought conditions: an epidemiologic study. Journal of Food Protection 55, 182–186Google Scholar
  519. 520.
    Benedetti, S., Iametti, S., Bonomi, F., Mannino, S., 2005: Head space sensor array for the detection of aflatoxin M1 in raw ewe’s milk. Journal of Food Protection 68, 1089–1092Google Scholar
  520. 521.
    Onyemelukwe, C.G., Nirodi, C., West, C.E., 1980: Aflatoxin B1 in hepatocellular carcinoma. Tropical and Geographical Medicine 32, 237–240Google Scholar
  521. 522.
    Sarr, A.B., Mayura, K., Kubena, L.F., Harvey, R.B., Phillips, T.D., 1995: Effects of phyllosilicate clay on the metabolic profile of aflatoxin B1 in Fischer-344 rats. Toxicology Letters 75, 145–151Google Scholar
  522. 523.
    Ruprich, J., Ostrý, V., 1993: Health risk assessment of the mycotoxin ochratoxin A to humans: Czech Republic – Brno – 1991/1992. Central European Journal of Public Health 2, 86–93Google Scholar
  523. 524.
    Hanna, G.D., Phillips, T.D., Kubena, L.F., Cysewski, S.J., Ivie, G.W., Heidelbaugh, N.D., Witzel, D.A., Hayes, A.W., 1981: High pressure liquid chromatographic determination of penicillic acid in chicken tissues. Poultry Science 60, 2246–2252Google Scholar
  524. 525.
    Prior, M.G., Sisodia, C.S., 1978: Ochratoxicosis in White Leghorn hens. Poultry Science 57, 619–623Google Scholar
  525. 526.
    Meyer, K., Usleber, E., Märtlbauer, E., Bauer, J., 1997: Analysis of zearalenone-metabolites in bile of gilts with reproductive problems. Berliner und Münchener Tierärztliche Wochenschrift 110, 281–283Google Scholar
  526. 527.
    Canela, R., Viladrich, R., Velazquez, C.A., Sanchis, V., 1994: A survey of porcine kidneys and chicken liver for ochratoxin A in Spain. Mycopathologia 125, 29–32Google Scholar
  527. 528.
    MacDougald, O.A., Thulin, A.J., Pestka, J.J., 1990: Determination of zearalenone and related metabolites in porcine urine by modified enzyme-linked immunosorbent assay. Journal of the Association of Official Analytical Chemists 73, 65–68Google Scholar
  528. 529.
    Kennedy, D.G., McEvoy, J.D.G., Blanchflower, W.J., Hewitt, S.A., Cannavan, A., McCaughey, W.J., Elliott, C.T., 1995: Possible naturally occurring zeranol in bovine bile in Northern Ireland. Journal of Veterinary Medicine Series B 42, 509–512Google Scholar
  529. 530.
    Dänicke, S., Goyarts, T., Valenta, H., Razzazi, E., Böhm, J., 2004: On the effects of deoxynivalenol (DON) in pig feed on growth performance, nutrients utilization and DON metabolism. Journal of Animal and Feed Science 13, 539–556Google Scholar
  530. 531.
    Golínski, P., Chelkowski, J., Konarkowski, A., Szebiotko, K., 1983: Mycotoxins in cereal grain. Part VI. The effect of ochratoxin A on growth and tissue residues of the mycotoxin in broiler chickens. Nahrung, 27, 251–256Google Scholar
  531. 532.
    Velasco, M.L.R., Delso, M.M.C., Escudero, D.O., 2003: ELISA and HPLC determination of the occurrence of aflatoxin M1 in raw cow’s milk. Food Additives and Contaminants 20, 276–280Google Scholar
  532. 533.
    Polychronaki, N., West, R.M., Turner, P.C., Amra, H., Abdel-Wahab, M., Mykkänen, H., El-Nezami, H., 2007: A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers. Food and Chemical Toxicology 45, 1210–1215Google Scholar
  533. 534.
    Amuzie, C.J., Harkema, J.R., Pestka, J.J., 2008: Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. Toxicology 248, 39–44Google Scholar
  534. 535.
    Shephard, G.S., Thiel, P.G., Sydenham, E.W., Alberts, J.F., Cawood, M.E., 1994: Distribution and excretion of a single dose of the mycotoxin fumonisin B1 in a non-human primate. Toxicon 32, 735–741Google Scholar
  535. 536.
    Breinholt, V., Hendricks, J., Pereira, C., Arbogast, D., Bailey, G., 1995: Dietary chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in rainbow trout. Cancer Research 55, 57–62Google Scholar
  536. 537.
    Dänicke, S., Brüssow, K.-P., Valenta, H, Ueberschär, K.-H., Tiemann, U., Schollenberger, M., 2005: On the effects of graded levels of Fusarium toxin contaminated wheat in diets for gilts on feed intake, growth performance and metabolism of deoxynivalenol and zearalenone. Molecular Nutrition & Food Research 49, 932–943Google Scholar
  537. 538.
    Petkova-Bocharova, T., Castegnaro, M., Pfohl-Leszkowicz, A., Garren, L., Grosso, F., Nikolov, I., Vrabcheva, T., Dragacci, S., Chernozemsky, I.N., 2003: Analysis of ochratoxin A in serum and urine of inhabitants from an area with Balkan endemic nephropathy: a one month follow up study. Facta Universitas Series: Medicine and Biology 10, 62–68Google Scholar
  538. 539.
    Hussain, I., Anwar, J., 2008: A study on contamination of aflatoxin M1 in raw milk in the Punjab province of Pakistan. Food Control 19, 393–395Google Scholar
  539. 540.
    Jonsyn, F.E., 1999: Intake of aflatoxins and ochratoxins by infants in Sierra Leone: possible effects on the general health of these children. Journal of Nutrition and Environmental Medicine 9, 15–22Google Scholar
  540. 541.
    Turner, P.C., Sylla, A., Gong, Y.Y., Diallo, M.S., Sutcliffe, A.E., Hall, A.J., Wild, C.P., 2005: Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in West Africa: a community-based intervention study. Lancet 365, 1950–1956Google Scholar
  541. 542.
    Burdaspal, P.A., Legarda, T.M., 1998: Datos sorbe la presencia de ocratoxina A en plasma humano en Espaňa. Alimentaria 292, 103–109 [Spanish]Google Scholar
  542. 543.
    Dänicke, S., Ueberschär, K.-H., Halle, I., Valenta, H., Flachowsky, G., 2001: Excretion kinetics and metabolism of zearalenone in broilers in dependence on a detoxifying agent. Archives of Animal Nutrition 55, 299–313Google Scholar
  543. 544.
    Aslam, M., Beg, A.E., Blaskewicz, M., Degen, G.H., Golka, K., 2005: Ochratoxin A blood concentration in healthy subjects and bladder cancer cases from Pakistan. Abstract, 27th Mycotoxin-Workshop, 13–15 June 2005, Dortmund, GermanyGoogle Scholar
  544. 545.
    Ngindu, A., Kenya, P.R., Ocheng, D.M., Omondi, T.N., Ngare, W., Gatei, D., Johnson, B.K., Ngira, J.A., Nandwa, H., Jansen, A.J., Kaviti, J.N., Arap Siongok, T., 1982: Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet 12, 1346–1348Google Scholar
  545. 546.
    Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J., Bailey, G., 1999: Chlorophyllin chemoprevention in trout initiated by aflatoxin B1 bath treatment: an evaluation of reduced bioavailability vs. target organ protective mechanisms. Toxicology and Applied Pharmacology 158, 141–151Google Scholar
  546. 547.
    Gemechu-Hatewu, M., Platt, K.-L., Oesch, F., Hacker, H.-J., Bannasch, P., Steinberg, P., 1997: Metabolic activation of aflatoxin B1 to aflatoxin B1–8,9-epoxide in woodchucks undergoing chronic active hepatitis. International Journal of Cancer 73, 587–591Google Scholar
  547. 548.
    Prasanna, H.R., Lu, M.H., Beland, F.A., Hart, R.W., 1989: Inhibition of aflatoxin B1 binding to hepatic DNA by dehydroepiandrosterone in vivo. Carcinogenesis 10, 2197–2200Google Scholar
  548. 549.
    Gradelet, S., Le Bon, A.-M., Suschetet, M., Astorg, P., 1998: Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in rat: role of the modulation of aflatoxin B1 metabolism. Carcinogenesis 19, 403–411Google Scholar
  549. 550.
    Salbe, A.D., Bjeldanes, L.F., 1989: Effect of diet and route of administration on the DNA binding of aflatoxin B1 in the rat. Carcinogenesis 10, 629–634Google Scholar
  550. 551.
    Kensler, T.W., Egner, P.A., Davidson, N.E., Roebuck, B.D., Pikul, A., Groopman, J.D., 1986: Modulation of aflatoxin metabolism, aflatoxin-N 7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferase. Cancer Research 46, 3924–3931Google Scholar
  551. 552.
    Lotlikar, P.D., Raj, H.G., Bohm, L.S., Ho, L.L., Jhee, E.-C., Tsujii, K., Gopalan, P., 1989: A mechanism of inhibition of aflatoxin B1-DNA binding in the liver by phenobarbital pretreatment of rats. Cancer Research 49, 951–957Google Scholar
  552. 553.
    Gresham, A., Done, S., Livesey, C., MacDonald, S., Chan, D., Sayers, R., Clark, C., Kemp, P., 2006: Survey of pigs’ kidneys with lesions consistent with PMWS and PDNS and ochratoxicosis. Part 1: concentrations and prevalence of ochratoxin A. Veterinary Record 159, 737–742Google Scholar
  553. 554.
    Turner, P.C., Sylla, A., Kuang, S.-Y., Marchant, C.L., Diallo, M.S., Hall, A.J., Groopman, J.D., Wild, C.P., 2005: Absence of TP53 codon 249 mutations in young Guinean children with high aflatoxin exposure. Cancer Epidemiology, Biomarkers & Prevention 14, 2053–2055Google Scholar
  554. 555.
    Boudra, H., Morgavi, D.P., 2006: Development and validation of a HPLC method for the quantitation of ochratoxins in plasma and raw milk. Journal of Chromatography B 843, 295–301Google Scholar
  555. 556.
    Gopalan-Kriczky, P., Hiruma, S., Lotlikar, P.D., 1994: Effect of glutathione levels on aflatoxin B1-DNA binding in livers and kidneys of male rats and hamsters pretreated with buthionine sulfoximine and diethylmaleate. Cancer Letters 76, 25–30Google Scholar
  556. 557.
    Norred, W.P., Porter, J.K., Dorner, J.W., Cole, R.J., 1988: Occurrence of the mycotoxin cyclopiazonic acid in meat after oral administration to chickens. Journal of Agricultural and Food Chemistry 36, 113–116Google Scholar
  557. 558.
    Takahashi, N., Harttig, U., Williams, D.E., Bailey, G.S., 1996: The model Ah-receptor agonist ß-naphthoflavone inhibts aflatoxin B1-DNA binding in vivo in rainbow trout at dietary levels that do not induce CYP1A enzymes. Carcinogenesis 17, 79–87Google Scholar
  558. 559.
    Autrup, J.L., Schmidt, J., Seremet, T., Autrup, H., 1991: Determination of exposure to aflatoxins among Danish workers in animal-feed production through the analysis of aflatoxin B1 adducts to serum albumin. Scandinavian Journal of Work, Environment & Health 17, 436–440Google Scholar
  559. 560.
    Dashwood, R.H., Breinholt, V., Bailey, G.S., 1991: Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis 12, 939–942Google Scholar
  560. 561.
    Schwerdt, G., Bauer, K., Gekle, M., Silbernagl, S., 1996: Accumulation of ochratoxin A in rat kidney in vivo and in cultivated renal epithelial cells in vitro. Toxicology 114, 177–185Google Scholar
  561. 562.
    Srivatanakul, P., Parkin, D.M., Jiang, Y.-Z., Khlat, M., Kao-Ian, U.-T., Sontipong, S., Wild, C., 1991: The role of infection by Opisthorchis viverrini, hepatitis B virus, and aflatoxin exposure in the etiology of liver cancer in Thailand. Cancer 68, 2411–2417Google Scholar
  562. 563.
    Mandel, H.G., Manson, M.M., Judah, D.J., Simpson, J.L., Green, J.A., Forrester, L.M., Wolf, C.R., Neal, G.E., 1987: Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat. Cancer Research 47, 5218–5223Google Scholar
  563. 564.
    Sylla, A., Diallo, M.S., Castegnaro, J.-J., Wild, C.P., 1999: Interactions between hepatitis B virus infection and exposure to aflatoxins in the development of hepatocellular carcinoma: a molecular epidemiological approach. Mutation Research 428, 187–196Google Scholar
  564. 565.
    Stresser, D.M., Williams, D.E., McLellan, L.I., Harris, T.M., Bailey, G.S., 1994: Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Drug Metabolism and Disposition 22, 392–399Google Scholar
  565. 566.
    Krogh, P., Elling, F., Hald, B., Jylling, B, Petersen, V.E., Skadiiauge, E., Svendsen, C.K., 1975: Experimental avian nephrophathy. Changes of renal function and structure induced by ochratoxin A-contaminated feed. Acta Pathologica et Microbiologica Scandinavica, Section A 84, 215–221Google Scholar
  566. 567.
    Veldman, A., 1992: Effect of sorbentia on carry-over of aflatoxin from cow feed to milk. Milchwissenschaft 47, 777–780Google Scholar
  567. 568.
    Fuchs, R., Radić, B., Čeović, S., Šoštarić, B., Hult, K., 1991: Human exposure to ochratoxin A. IARC Scientific Publications 115, 131–135Google Scholar
  568. 569.
    Nyathi, C.B., Mutiro, C.F., Hasler, J.A., Chetsanga, C.J., 1989: Human exposure to aflatoxins in Zimbabwe. Central African Journal of Medicine 35, 542–545Google Scholar
  569. 570.
    Richir, C.L., Paccalin, J., Larcebeau, S., Faugeres, J., Morard, J.-L., Lamant, M., 1979: Presence d’aflatoxine B1 dans le foie humain. Cahiers de Nutrition et de Diététique 11, 223–226Google Scholar
  570. 571.
    Yu, M.-W., Lien, J.-P., Liaw, Y.-F., Chen, C.-J., 1996: Effects of multiple risk factors for hepatocellular carcinoma on formation of aflatoxin B1-DNA adducts. Cancer Epidemiology, Biomarkers & Prevention 5, 613–619Google Scholar
  571. 572.
    Byrem, T.M., Pestka, J.J., Chu, F.S., Strasburg, G.M., 1999: Analysis and pharmacokinetics of cyclopiazonic acid in market weight pigs. Journal of Animal Science 77, 173–179Google Scholar
  572. 573.
    Petkova-Bocharova, T., Castegnaro, M., 1991: Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary tract tumours in Bulgaria. In: Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Ed. Castegnaro, M., Dirheimer, G., Chemozemsky, I.N., Bartsch, H. Lyon, International Agency for Research on Cancer, pp. 135–137, IARC, 1991Google Scholar
  573. 574.
    Bintvihok, A., Kositcharoenkul, S., 2006: Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Toxicon 47, 41–46Google Scholar
  574. 575.
    Megalla, S.E., Kamel, Y.Y., Abdel-Fattah, H.M., Hafez, A.H., 1981: Determining the kinetic behaviour for the secretion of milk toxin as related to dosage level of aflatoxin B1. Zeitschrift für Ernährungswissenschaften 20, 216–222Google Scholar
  575. 576.
    Tangni, E.K., Waegeneers, N., van Overmeire, I., Goeyens, L., Pussemier, L., 2009: Mycotoxin analyses in some home produced eggs in Belgium reveal small contribution to the total intake. Science of the Total Environment 407, 4411–4418Google Scholar
  576. 577.
    Bintvihok, A., Davitiyananda, D., Kositcharoenkul, S., Panichkriangkrai, W., Jamratchai, O., 1998: Residues of aflatoxins and their metabolites in chicken tissues in Thailand. Journal of Toxicological Science 23 (Suppl. II), 389Google Scholar
  577. 578.
    Hirano, K., Adachi, Y., Ishibashi, S., Sueyoshi, M., Bintvihok, A., Kumazawa, N.H., 1991: Detection of aflatoxin B1 in plasma of fowl receiving feed naturally contaminated with aflatoxin B1. Journal of Veterinary Medical Science 53, 1083–1085Google Scholar
  578. 579.
    Shin, B.S., Hong, S.H., Hwang, S.W., Kim, H.J., Lee, J.B., Yoon, H.-S., Kim, D.J., Yoo, S.D., 2009: Determination of zearalenone by liquid chromatography/tandem mass spectrometry and application to a pharmacokinetic study. Biomedical Chromatography 23, 1014–1021Google Scholar
  579. 580.
    Duarte, S.C., Bento, J.M.V., Pena, A., Lino, C.M., 2009: Ochratoxin A exposure assessment of the inhabitants of Lisbon during winter 2007/2008 through bread and urine analysis. Food Additives and Contaminants 26, 1411–1420Google Scholar
  580. 581.
    Stoev, S.D., Dutton, M.F., Njobeh, P.B., Mosonik, J.S., Steenkamp, P.A., 2010: Mycotoxic nephropathy in Bulgarian pigs and chickens: complex aetiology and similarity to Balkan Endemic Nephropathy. Food Additives and Contaminants 27, 72–88Google Scholar
  581. 582.
    Mizrak, D., Engin, B., Önder, F.O., Yener, B., Bektaş, M., Biyikili, Z., Idilman, R., Çinar, K., Karayalçin, K., Ersöz, S., Karayalçin, S., Özden, A., Yurdaydin, C., Yazihan, N., Ataoğlu, H., Bozkaya, H., Uzunalimoğlu, Ö., 2009: Aflatoxin exposure in viral hepatitis patients in Turkey. Turkish Journal of Gastroenterology 20, 192–197Google Scholar
  582. 583.
    Battacone, G., Nudda, A., Palomba, M., Mazette, A., Pulina, G., 2009: The transfer of aflatoxin M1 in milk of ewes fed diet naturally contaminated by aflatoxins and effect of inclusion of dried yeast culture in the diet. Journal of Dairy Science 92, 4997–5004Google Scholar
  583. 584.
    Coronel, M.B., Sanchis, V., Ramos, A.J., Marin, S., 2009: Assessment of the exposure to ochratoxin A in the province of Lleida, Spain. Food and Chemical Toxicology 47, 2847–2852Google Scholar
  584. 585.
    Shin, B.S., Hong, S.H., Bulitta, J.B., Hwang, S.W., Kim, H.J., Lee, J.B., Yang, S.D., Kim, J.E., Yoon, H.-S., Kim, D.J., Yoo, S.D., 2009: Disposition, oral bioavailability, and tissue distribution of zearalenone in rats at various dose levels. Journal of Toxicology and Environmental Health Part A 72, 1406–1411Google Scholar
  585. 586.
    Eriksen, G.S., Hultin Jäderlund, K., Moldes-Anaya, A., Schönheit, J., Bernhoft, A., Jæger, G., Rundberget, T., Skaar, I., 2010: Poisoning of dogs with tremorgenic Penicillium toxins. Medical Mycology 48, 188–196Google Scholar
  586. 587.
    Layton, R.C., Purdy, C.W., Jumper, C.A., Straus, D.C., 2009: Detection of macrocyclic trichothecene mycotoxin in a caprine (goat) tracheal instillation model. Toxicology and Industrial Health 25, 693–701Google Scholar
  587. 588.
    Gürbay, A., Atasayar Sabuncuonğlu, S., Girgin, G., Şahin, G., Yiğit, Ş., Yurdakök, M, Tekinalp, G., 2010: Exposure of newbornes to aflatoxin M1 and B1 from mothers’ breast milk in Ankara, Turkey. Food and Chemical Toxicology 48, 314–319Google Scholar
  588. 589.
    Alonso, V.A., Monge, M.P., Larriestra, A., Dalcero, A.M., Cavaglieri, L.R., Chiacchiera, S.M., 2010: Naturally occurring aflatoxin M1 in raw bulk milk from farm cooling tanks in Argentina. Food Additives and Contaminants 27, 373–379Google Scholar
  589. 590.
    Niemiec, J., Borzemska, W., Goliński, P., Karpińska, E., Szeleszuk, P., Celeda, T., 1994: The effect of ochratoxin A on egg quality, development of embryos and the level of toxin in eggs and tissues of hens and chicks. Journal of Animal and Feed Sciences 3, 309–316Google Scholar
  590. 591.
    Abdelhamid, A.M., Dorra, T.M., 1990: Study on the effects of feeding laying hens on separate mycotoxins (aflatoxins, patulin, or citrinin)-contaminated diets on the egg quality and tissue constituents. Archiv Tierernährung 40, 305–316Google Scholar
  591. 592.
    Abdel-Wahab, M., Mostafa, M., Sabry, M., El-Farrash, M., Yousef, T., 2008: Aflatoxins as a risk factor for hepatocellular carcinoma in Egypt, Mansoura Gastroenterology Center Study. Hepato-Gastroenterology 55, 1754–1759Google Scholar
  592. 593.
    Adekunle, A.A., 1980: A comparative study on the biliary excretion of aflatoxin B1 in the albino Rat (Rattus norvegicus) and the African giant rat (Cricetomys gambianus, Waterhouse). Comparative Biochemistry and Physiology 66, 105–109Google Scholar
  593. 594.
    Allameh, A., Saxena, M., Raj, H.G., 1989: Interaction of aflatoxin B1 metabolites with cellular macromolecules in neonatal rats receiving carcinogen through mother’s milk. Carcinogenesis 10, 2131–2134Google Scholar
  594. 595.
    Arulmozhi, A., Varghese, K., Ismail, P.K., Peethambaran, P.A., Ramachandran, K.M., 2002: Aflatoxin residues in tissues of broiler chicken. Indian Veterinary Journal 79, 901–903Google Scholar
  595. 596.
    Bean, T.A., Yourtee, D.M., 1989: Aflatoxin metabolites in the urine of Nigerians comparison of chromatographic methods. Journal of Toxicology – Toxin Reviews 8, 43–52Google Scholar
  596. 597.
    Beaver, R.W., Wilson, D.M., James, M.A., Haydon, K.D., Colvin, B.M., Sangster, L.T., Pikul, A.H., Groopman, J.D., 1990: Distribution of aflatoxins in tissues of growing pigs fed an aflatoxin-contaminated diet amended with a high affinity aluminosilicate sorbent. Veterinary and Human Toxicology 32, 16–18Google Scholar
  597. 598.
    Bennett, R.A., Essigmann, J.M., Wogan, G.N., 1981: Excretion of an aflatoxin-guanine adduct in the urine of aflatoxin B1-treated rat. Cancer Research 41, 650–654Google Scholar
  598. 599.
    Kleinova, M., Zöllner, P., Kahlbacher, H., Hochsteiner, W., Lindner, W., 2002: Metabolic profiles of the mycotoxin zearalenone and of the growth promoter zeranol in urine, liver, and muscle of heifers. Journal of Agricultural and Food Chemistry 50, 4769–4776Google Scholar
  599. 600.
    Zöllner, P., Jodlbauer, J., Kleinova, M., Kahlbacher, H., Kuhn, T., Hochsteiner, W., Lindner, W., 2002: Concentration levels of zearalenone and its metabolites in urine, muscle tissue, and liver samples of pigs fed with mycotoxin-contaminated oats. Journal of Agricultural and Food Chemistry 50, 2494–2501Google Scholar
  600. 601.
    Niemiec, J., Scholtyssek, S., Bauer, J., 1988: Ochratoxin A in the broiler feed: effect on weight gain and residues in the tissues. Archiv für Geflügelkunde 52, 163–168Google Scholar
  601. 602.
    Buss, P., Caviezel, M., Lutz, W.K., 1990: Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B1. Carcinogenesis 11, 2133–2135Google Scholar
  602. 603.
    Chen, C.-J., Zhang, Y.-J., Lu, S.-N., Santella, R.M., 1992: Aflatoxin B1 DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma. Hepatology 16, 1150–1155Google Scholar
  603. 604.
    Coulombe, R.A., Jr., Huie, J.M., Ball, W., Sharma, R.P., Wilson, D.W., 1991: Pharmacokinetics of intratracheally administered aflatoxin B1. Toxico-logy and Applied Pharmacology 109, 196–206Google Scholar
  604. 605.
    Egner, P.A., Gange, S.J., Dolan, P.M., Groopman, J.D., Muňoz, A., Kensler, T.W., 1995: Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz. Carcinogenesis 16, 1769–1773Google Scholar
  605. 606.
    Friend, D.W., Trenholm, H.L., Thompson, B.K., Prelusky, D.B., Hartin, K.H., 1986: Effect of deoxynivalenol (DON)-contaminated diet fed to growing-finishing pigs on their performance at market weight, nitrogen retention and DON excretion. Canadian Journal of Animal Science 66, 1075–1085Google Scholar
  606. 607.
    Gan, L.-S., Skipper, P.L., Peng, X., Groopman, J.D., Chen, J.-S., Wogan, G.N., Tannenbaum, S.R., 1988: Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B1 intake and urinary excretion of aflatoxin M1. Carcinogenesis 9, 1323–1325Google Scholar
  607. 608.
    Garner, R.C., Wright, C.M., 1975: Binding of [14C]aflatoxin B1 to cellular macromolecules in the rat and hamster. Chemico-Biological Interactions 11, 123–131Google Scholar
  608. 609.
    Gregory, J.F., III, Manley, D.B., 1982: High performance liquid chromatographic quantitation of aflatoxin metabolites in animal tissues. Journal of the Association of Official Analytical Chemists 65, 869–875Google Scholar
  609. 610.
    Groopman, J.D., Busby Jr, W.F., Wogan, G.N., 1980: Nuclear distribution of aflatoxin B1 and its interaction with histones in rat liver in vivo. Cancer Research 40, 4343–4351Google Scholar
  610. 611.
    Groopman, J.D., DeMatos, P., Egner, P.A., Love-Hunt, A., Kensler, T.W., 1992: Molecular dosimetry of urinary aflatoxin-N 7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis 13, 101–106Google Scholar
  611. 612.
    Jennings, G.S., Oesch, F., Steinberg, P., 1992: In vivo formation of aflatoxin B1-DNA adducts in parenchymal and non-parenchymal cells of rat liver. Carcinogenesis 13, 831–835Google Scholar
  612. 613.
    Kumagai, S., 1985: Ochratoxin A: plasma concentration and excretion into bile and urine in albumin-deficient rats. Food and Chemical Toxicology 23, 941–943Google Scholar
  613. 614.
    Larsson, P., Tjälve, H., 1993: Distribution and metabolism of aflatoxin B1 in the marmoset monkey (Callithrix jacchus). Carcinogenesis 14, 1–6Google Scholar
  614. 615.
    Loury, D.N., Hsieh, D.P.H., 1984: Effects of chronic exposure to aflatoxin B1 and aflatoxin M1 on the in vivo covalent binding of aflatoxin B1 to hepatic macromolecules. Journal of Toxicology and Environmental Health 13, 575–587Google Scholar
  615. 616.
    Monroe, D.H., Eaton, D.L., 1987: Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse. Toxicology and Applied Pharmacology 90, 401–409Google Scholar
  616. 617.
    Obioha, W.I., Stahr, H.M., Kraft, A.A., 1986: Distribution and effects of aflatoxin in chicken tissues after feeding radiolabeled (14C) aflatoxin B1. Journal of Food Protection 49, 799–805Google Scholar
  617. 618.
    Olubuyide, I.O., Makarananda, K., Judah, D.J., Neal, G.E., 1991: Investigation of the assay of AFB1-albumin adducts using proteolysis products in ELISA. International Journal of Cancer 48, 468–472Google Scholar
  618. 619.
    Prelusky, D.B., Savard, M.E., Trenholm, H.L., 1995: Pilot study on the plasma pharmacokinetics of fumonisin B1 in cows following a single dose by oral gavage or intravenous administration. Natural Toxins 3, 389–394Google Scholar
  619. 620.
    Prelusky, D.B., Veira, D.M., Trenholm, H.L., 1985: Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep. Journal of Environmental Science and Health B20, 603–624Google Scholar
  620. 621.
    Roebuck, B.D., Liu, Y.-L., Rogers, A.D., Groopman, J.D., Kensler, T.W., 1991: Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry. Cancer Research 51, 5501–5506Google Scholar
  621. 622.
    Scholl, P.F., McCoy, L., Kenseler, T.W., Groopman, J.D., 2006: Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry. Chemical Research in Toxicology 19, 44–49Google Scholar
  622. 623.
    Shephard, G.S., Thiel, P.G., Sydenham, E.W., Alberts, J.F., 1994: Biliary excretion of the mycotoxin fumonisin B1 in rats. Food and Chemical Toxicology 32, 489–491Google Scholar
  623. 624.
    Stresser, D.M., Bailey, G.S., Williams, D.E., 1994: Indole-3-carbinol and β-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxification of aflatoxin B1 in the rat. Drug Metabolism and Disposition 22, 383–391Google Scholar
  624. 625.
    Toledo, C., Hendricks, J., Loveland, P., Wilcox, J., Bailey, G., 1987: Metabolism and DNA-binding in vivo of aflatoxin B1 in medaka (Oryzias latipes). Comparative Biochemistry and Physiology 87C, 275–281Google Scholar
  625. 626.
    Troxel, C.M., Reddy, A.P., O’Neal, P.E., Hendricks, J.D., Bailey, G.S., 1997: In vivo aflatoxin B1 metabolism and hepatic DNA adduction in zebrafish (Danio rerio). Toxicology and Applied Pharmacology 143, 213–220Google Scholar
  626. 627.
    Turner, P.C., Dingley, K.H., Coxhead, J., Russell, S., Garner, C.R., 1998: Detectable levels of serum aflatoxin B1-albumin adducts in the United Kingdom population: implications for aflatoxin-B1 exposure in the United Kingdom. Cancer Epidemiology, Biomarkers & Prevention 7, 441–447Google Scholar
  627. 628.
    Valsta, L.M., Hendricks, J.D., Bailey, G.S., 1988: The significance of glutathione conjugation for aflatoxin B1 metabolism in rainbow trout and coho salmon. Food and Chemical Toxicology 2, 129–135Google Scholar
  628. 629.
    Wild, C.P., Jiang, Y-Z., Sabbioni, G., Chapot, B., Montesano, R., 1990: Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Research 50, 245–251Google Scholar
  629. 630.
    Zaghini, A., Martelli, G., Roncada, P., Simioli, M., Rizzi, L., 2005: Mannanoligosaccharides and aflatoxin B1 in feed for laying hens: effects on egg quality, aflatoxin B1 and M1 residues in eggs, and aflatoxin B1 levels in liver. Poultry Science 84, 825–832Google Scholar
  630. 631.
    Moldes-Anaya, A., Wilkins, A.L., Rundberget, T., Fæste, C.K., 2009: In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A. Drug and Chemical Toxicology 32, 26–37Google Scholar
  631. 632.
    Lásztity, R., Bata, Á., Palyusik, M., 1989: Investigation of the distribution of zearalenone and its metabolites in the pig fed with feed contaminated by zearalenone. Periodica Polytechnica-Chemical Engineering 33, 203–209Google Scholar
  632. 633.
    Zomborszky-Kovács, M., Vetési, F., Kovács, F., Bata, A., Tóth, Á., Tornyos, G., 2000: Preliminary communication: examination of the harmful effect to fetuses of fumonisin B1 in pregnant sows. Teratogenesis, Carcinogenesis, and Mutagenesis 20, 293–299Google Scholar
  633. 634.
    Quist, C.F., Howerth, E.W., Fischer, J.R., Wyatt, R.D., Miller, D.M., Nettles, V.F., 1997: Evaluation of low-level aflatoxin in the diet of white-tailed deer. Journal of Wildlife Diseases 33, 112–121Google Scholar
  634. 635.
    Duca, R.C., Bravin, F., Delaforge, M., Vladescu, L., Badea, I.A., Criste, R.D., 2009: Development of a new HPLC method used for determination of zearalenone and its metabolites in broiler samples. Influence of zearalenone on the nutritional properties of broiler meat. Journal of Agricultural and Food Chemistry 57, 10497–10504Google Scholar
  635. 636.
    Gürbay, A., Girgin, G., Atasayar Sabuncuoğlu, S., Sahin, G., Yurdakök, M., Yiğit, Ş, Tekinalp, G., 2010: Ochratoxin A: is it present in breast milk samples obtained from mothers from Ankara, Turkey? Journal of Applied Toxicology 30, 329–333Google Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.BonnGermany

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