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Actin and Diseases of the Nervous System

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Neurobiology of Actin

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 5))

Abstract

Abnormal regulation of the actin cytoskeleton results in several pathological conditions affecting primarily the nervous system. Those of genetic origin arise during development, but others manifest later in life. Actin regulation is also affected profoundly by environmental factors that can have sustained consequences for the nervous system. Those consequences follow from the fact that the actin cytoskeleton is essential for a multitude of cell biological functions ranging from neuronal migration in cortical development and dendritic spine formation to NMDA receptor activity in learning and alcoholism. Improper regulation of actin, causing aggregation, can contribute to the neurodegeneration of amyloidopathies, such as Down’s syndrome and Alzheimer’s disease. Much progress has been made in understanding the molecular basis of these diseases.

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Acknowledgments

We gratefully acknowledge support from the National Institutes of Health, grants NS40371 (JRB) and NS43115 (MTM and JRB) from the National Institute of Neurological Disorders and Stroke and HD055745 (MTM) from the National Institute of Child Health and Human Development.

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  1. Department of Biochemistry and Molecular Biology, Cellular and Integrative Neuroscience Program, Colorado State University, Fort Collins, CO, 80523, USA

    Barbara W. Bernstein & James R. Bamburg

  2. Neuroscience Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Michael T. Maloney

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Correspondence to James R. Bamburg .

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  1. , Dept Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, 19129, Pennsylvania, USA

    Gianluca Gallo

  2. 4-140 MCB, Department of Neuroscience, University of Minnesota, 321 Church St., Minneapolis, 55455, Minnesota, USA

    Lorene M. Lanier

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Bernstein, B.W., Maloney, M.T., Bamburg, J.R. (2011). Actin and Diseases of the Nervous System. In: Gallo, G., Lanier, L. (eds) Neurobiology of Actin. Advances in Neurobiology, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7368-9_11

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