Native Human and Bioprosthetic Heart Valve Dynamics

  • Hyunggun Kim
  • Jia Lu
  • K.B. ChandranEmail author


Native human heart valves undergo complex deformation during a cardiac cycle and the tissue leaflets are subjected to regions of stress concentrations particularly during the opening and closing phases. Diseases of the heart valves include stenosis and valvular incompetence and the valves in the left heart (aortic and mitral valves) subjected to higher pressure loads are more prone to these diseases. A correlation has been established between regions of high stress concentration on the leaflets and regions of calcification and tissue failure. Computational simulations play a significant role in the determination of stress distribution on the leaflets during a cardiac cycle. In this chapter, the development of state-of-the-art structural analysis of the biological leaflet valves as well as fluid–structure interaction algorithms for the analysis of biological tissue valve dynamics are described. The potential application of the computational analyses on improving the design of biological heart valve prostheses is discussed. The need for further advancements in multiscale simulation for increasing our understanding of the effect of mechanical stresses on the leaflet microstructure is also pointed out.


Aortic Valve Mitral Valve Heart Valve Valve Leaflet Mitral Valve Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Cardiology, Department of Internal MedicineThe University of Texas Health Science Center at HoustonHoustonUSA
  2. 2.Department of Mechanical and Industrial EngineeringThe University of Iowa, 2137 Seamans CenterIowa CityUSA
  3. 3.Department of Biomedical EngineeringCollege of Engineering, 1138 Seamans Center, The University of IowaIowa CityUSA

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