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Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems pp 375–402Cite as

Computational Analyses of Airway Flow and Lung Tissue Dynamics

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Abstract

The function of the mammalian respiratory system is the facilitation the transfer of gas exchange between the organism’s environment and its internal transport medium, the blood. Evolutionary processes have optimized the anatomic structure of the lung as a tree-like branching network of airways terminating in thin-walled elastic ducts and alveoli, where this gas exchange occurs. Both dissipative and elastic properties of the respiratory system contribute to its unique static and dynamic mechanical behavior. In this chapter, we will explore the various structural and functional relationships of the respiratory system, and review several computational and modeling analyses that provide insight into the pathophysiology of common respiratory diseases. Particular emphasis is placed on studies that utilize imaging to help understand and/or validate the distributed regional nature of lung function.

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Acknowledgments

Supported in part by National Heart, Lung, and Blood Institute Grants K08 HL-089227. The authors wish to thank Dr. Jason H.T. Bates for his many helpful suggestions.

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Authors and Affiliations

  1. Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA

    David W. Kaczka

  2. University of Toledo School of Medicine, Toledo, OH, 43614, USA

    Ashley A. Colletti

  3. Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand

    Merryn H. Tawhai

  4. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA

    Brett A. Simon

Authors
  1. David W. Kaczka
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  2. Ashley A. Colletti
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  3. Merryn H. Tawhai
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  4. Brett A. Simon
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Correspondence to David W. Kaczka .

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Editors and Affiliations

  1. College of Engineering, Seamans Center, University of Iowa, Iowa City, 52242-1527, Iowa, USA

    Krishnan B. Chandran

  2. College of Engineering, Seamans Center, University of Iowa, Iowa City, 52242-1527, Iowa, USA

    H. S. Udaykumar

  3. College of Engineering, Seamans Center, University of Iowa, Iowa City, 52242-1527, Iowa, USA

    Joseph M. Reinhardt

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Kaczka, D.W., Colletti, A.A., Tawhai, M.H., Simon, B.A. (2010). Computational Analyses of Airway Flow and Lung Tissue Dynamics. In: Chandran, K., Udaykumar, H., Reinhardt, J. (eds) Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7350-4_10

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  • DOI: https://doi.org/10.1007/978-1-4419-7350-4_10

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