Abstract
Multi-component reactions (MCRs) have now been well established as a powerful synthetic tool for creating molecular complexity and diversity and are undoubtedly well suited for the drug discovery program. Another potential that has probably received less attention among synthetic chemists is the opportunity offered by MCRs for the development of new fundamentally important transformations (reactions). Indeed, although an MCR is composed of a series of known bimolecular reactions, the overall transformation could be novel. Consequently, it provides chemists the opportunities to uncover transformations that were otherwise difficult to realize. In this talk, we will present our recent work in this field, including: (1) the oxidative homologation of aldehydes to amides, (2) the oxidative coupling of aldehydes and isocyanides to α-ketoamides, (3) oxidative isocyanide-based MCRs, and (4) the enantioselective Passerini reaction.
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Acknowledgment
Our research has been executed with the financial support of grant no. RFFI 07-03-0001, the program of Presidium of the Russian Academy of Sciences, on the theme “Development of Methods of Obtaining of Chemical Substances and Creation of New Materials.”
This work was supported by the Russian Foundation for Basic Research (grant no. 08-03-00067-a).
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Zhu, J. et al. (2011). Design of Multi-Component Reactions. In: Mironov, M. (eds) MCR 2009. Advances in Experimental Medicine and Biology, vol 699. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7270-5_5
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DOI: https://doi.org/10.1007/978-1-4419-7270-5_5
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