Spray Drying, Spray Pyrolysis and Spray Freeze Drying

  • M. EslamianEmail author
  • N. AshgrizEmail author


In conventional spray pyrolysis (CSP or simply SP), a solution is sprayed into a carrier gas forming small droplets; owing to the high temperature of the surrounding gas, the solvent is vaporized and the solute is precipitated on and within the droplets. If the air temperature is high enough, solute is decomposed to form final solid particles. A schematic diagram of the spray pyrolysis process is shown in Fig. 37.1 [1]. Spray drying (SD) is similar to spray pyrolysis, except that there is no chemical decomposition in SD and usually the process temperature is lower. SP and SD techniques may produce fully-filled or hollow particles depending on the operating conditions. In general, for most materials, hollow particles are formed if at the onset of solute precipitation on the droplet surface, the solute concentration at the droplet center is lower than the equilibrium saturation (Jayanthi et al. [2]). However, Chau et al. [3] showed that Jayanthi’s model is not applicable to the formation of NaCl particles.


Spray Pyrolysis Hollow Particle Solution Droplet Initial Solution Concentration Droplet Center 
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  1. 1.
    M. Eslamian, M. Ahmed, and N. Ashgriz: Modeling of nanoparticle formation during spray pyrolysis. Nanotechnology, 17, 1674–1685 (2006).CrossRefGoogle Scholar
  2. 2.
    G. V. Jayanthi, S. C. Zhang, and G. L. Messing: Modeling of solid particle formation during solution aerosol thermolysis. Aerosol Science and Technology, 19, 478–490 (1993).CrossRefGoogle Scholar
  3. 3.
    A. Chau, M. Eslamian, and N. Ashgriz: On production of non-disrupted particles by spray pyrolysis. Particle and Particle Systems Characterization, 25, 183–191 (2008).CrossRefGoogle Scholar
  4. 4.
    H. R. Costantino and M. J. Pikal, Lyophilization of Biopharmaceuticals,  Chapter 13: Spray Freeze Drying of Biopharmaceuticals: Applications and Stability Considerations. American Association of Pharmaceuticals Scientists; Springer, Arlington, (2004).Google Scholar
  5. 5.
    Y-F. Maa, P. Nguyen, T. Sweeney, S. Shire, and C. Hsu: Protein inhalation powders: spray drying vs. spray freeze drying. Pharmaceutical Research, 16, 249–255 (1999).CrossRefGoogle Scholar
  6. 6.
    Y-F. Maa and S. Prestrelski: Biopharmaceutical powders: particle formation and formulation considerations. Current Pharmaceutical Biotechnology, 1, 283–302 (2000).CrossRefGoogle Scholar
  7. 7.
    Y. Xiong and T. T. Kodas: Droplet evaporation and solute precipitation during spray pyrolysis. Journal of Aerosol Science, 24(7), 893–908 (1993).CrossRefGoogle Scholar
  8. 8.
    I. W. Lenggoro, I. W. T. T. Hata, F. Iskandar, M. M. Lunden, and K. Okuyama: An experimental and modeling investigation of particle production by spray pyrolysis using a laminar flow aerosol reactor. Journal of Material Research, 15(3), 733–743 (2000).CrossRefGoogle Scholar
  9. 9.
    M. Farid: A new approach to modeling of single droplet drying. Chemical Engineering Science, 58, 2985–2993 (2003).CrossRefGoogle Scholar
  10. 10.
    M. Eslamian, M. Ahmed, and N. Ashgriz: Modeling of particle formation via droplet-to-particle spray methods. Drying Technology, 27, 1–11 (2009).CrossRefGoogle Scholar
  11. 11.
    M. Eslamian and N. Ashgriz: The effect of pressure on the morphology of spray-dried magnesium sulfate powders. Canadian Journal of Chemical Engineering, 84(5), 581–589 (2006).CrossRefGoogle Scholar
  12. 12.
    M. Eslamian and N. Ashgriz: The effect of pressure on the crystallinity and morphology of powders prepared by spray pyrolysis. Powder Technology, 167, 149–159 (2006).CrossRefGoogle Scholar
  13. 13.
    M. Eslamian and N. Ashgriz: Effect of atomization method on the morphology of spray generated particles. ASME Journal of Engineering Materials and Technology, 129(1), 130–142 (2007).CrossRefGoogle Scholar
  14. 14.
    L. Amirav and E. Lifshitz: WO06035425A2 (2006).Google Scholar
  15. 15.
    B. W. Han, J. S. Suh and M. S. Choi: US200693750A1 (2006).Google Scholar
  16. 16.
    M. Eslamian and M. Shekarriz: Recent advances in nanoparticle preparation by spray and microemulsion methods. Recent Patents on Nanotechnology, 3(2), 99–115 (2009).CrossRefGoogle Scholar
  17. 17.
    B. Xia, I. W. Lenggoro and K. Okuyama: Synthesis of CeO2 nanoparticles by salt-assisted ultrasonic aerosol decomposition. Journal of Material Chemistry, 13, 2925–2927 (2001).CrossRefGoogle Scholar
  18. 18.
    N. Jakic, J. Gregory, M. Eslamian and N. Ashgriz: Effect of impurities on the characteristics of metal oxides produced by spray pyrolysis. Journal of Materials Science, 44(8) 1977–1986 (2009).CrossRefGoogle Scholar
  19. 19.
    W. Nimmo, N. J. Ali, R. M. Brydson, C. Calvert, E. Hampartsoumian, D. Hind and S. J. Milne: Formation of lead zirconate titanate powders by spray pyrolysis. Journal of American Ceramic Society, 86(9), 1474–1480 (2003).CrossRefGoogle Scholar
  20. 20.
    T. Fukui, S. Ohara, K. Murata, H. Yoshida, K. Miura, T. Inagaki: Performance of intermediate temperature solid oxide fuel cells with La(Sr)Ga(Mg)O-3 electrolyte film. Journal of Power Sources, 106(1–2), 171–176 (2002).Google Scholar
  21. 21.
    Z. Bakenov, M. Wakihara and I. Taniguchi: Battery performance of nanostructured lithium manganese oxide synthesized by ultrasonic spray pyrolysis at elevated temperature. Journal of Solid State Electrochemistry, 12, 57–62 (2008).CrossRefGoogle Scholar
  22. 22.
    D. F. Fletcher, B. Guo, D. J. E. Harvie, T. A. G. Langrish, J. J. Nijdam and J. Williams: What is important in the simulation of spray dryer performance and how do current CFD models perform? Applied Mathematical Modelling, 30(11), 1281–1292 (2006).CrossRefGoogle Scholar

Copyright information

© Springer US 2011

Authors and Affiliations

  1. 1.Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoCanada

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