Abstract
Some reactions proceed via an intermediate that is stable enough to be detected with sensitive isotope techniques.One example is the transfer of the γ -phosphate group to aspartic acid in P-type ATPases, forming an acyl-phosphate intermediate, from which ADP is released followed by dephosphorylation:
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Buxbaum, E. (2011). Isotope Exchange. In: Biophysical Chemistry of Proteins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7251-4_40
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DOI: https://doi.org/10.1007/978-1-4419-7251-4_40
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