A Systems-Biology Approach to Yeast Actin Cables

  • Tyler Drake
  • Eddy Yusuf
  • Dimitrios VavylonisEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 736)


We focus on actin cables in yeast as a model system for understanding cytoskeletal organization and the workings of actin itself. In particular, we highlight quantitative approaches on the kinetics of actin-cable assembly and methods of measuring their morphology by image analysis. Actin cables described by these studies can span greater lengths than a thousand end-to-end actin-monomers. Because of this difference in length scales, control of the actin-cable system constitutes a junction between short-range interactions – among actin-monomers and nucleating, polymerization-facilitating, side-binding, severing, and cross-linking proteins – and the emergence of cell-scale physical form as embodied by the actin cables themselves.


Actin Filament Fission Yeast Fluorescence Recovery After Photobleaching Persistence Length Actin Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH Grant R21GM083928. We thank Nikola Ojkic, Matt Smith, and Jian-Qiu Wu for discussions.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PhysicsLehigh UniversityBethlehemUSA
  2. 2.Physics DepartmentSurya College of Education, Surya Research and Education (SURE) CenterTangerangIndonesia

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