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Mitochondrial DNA and Heart Disease

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Genes and Cardiovascular Function

Abstract

The relationship between abnormalities of myocardial mitochondrial DNA and heart disease is reviewed. Myocardial mitochondrial DNA abnormalities can induce both hypertrophic and dilated cardiomyopathies. In mitochondrial encephalomyopathy, abnormalities of myocardial mitochondrial DNA can also induce cardiac involvement, for example, heart failure and arrhythmia. The influence of acquired mitochondrial DNA mutations is also discussed.

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Authors and Affiliations

  1. Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan

    Chihiro Shikata

  2. Department of Internal Medicine, Aoto Hospital, Jikei University, Tokyo, Japan

    Masami Nemoto, Takanori Ebisawa, Akihiro Nishiyama & Nobuakira Takeda

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  1. Chihiro Shikata
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  2. Masami Nemoto
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  3. Takanori Ebisawa
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  4. Akihiro Nishiyama
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  5. Nobuakira Takeda
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Correspondence to Nobuakira Takeda .

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Editors and Affiliations

  1. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

  2. Jikei University School of Medicine, Shibuya-ku, Ebisu 3-31-6, Tokyo, 150-0013, Japan

    Makoto Nagano

  3. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

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Shikata, C., Nemoto, M., Ebisawa, T., Nishiyama, A., Takeda, N. (2011). Mitochondrial DNA and Heart Disease. In: Ostadal, B., Nagano, M., Dhalla, N. (eds) Genes and Cardiovascular Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7207-1_8

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