MALDI Imaging of Formalin-Fixed Paraffin-Embedded Tissues: Application to Model Animals of Parkinson Disease for Biomarker Hunting

  • Isabelle Fournier
  • Julien Franck
  • Céline Meriaux
  • Michel Salzet
Chapter
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 2)

Abstract

After 10 years of important technical developments, MALDI Imaging Mass Spectrometry appears to be a sufficiently mature technology to be introduced in laboratories as a practical approach to exploring tissue properties at the molecular level, particularly in the comparison of normal vs. pathological states to study neurological diseases such as Parkinson’s. In this report, we will present the technology and the development to enable the use of formalin fixed and paraffin embedded tissue (FFPE) tissue in order to examine banked hospital clinical samples.

Keywords

MALDI imaging Pathologies Developments Proteomics 

Notes

Acknowledgments

Supported by grants from Centre National de la Recherche Scientifique (CNRS), Ministère de L’Education Nationale, de L’Enseignement Supérieur et de la Recherche, Agence Nationale de la Recherche (ANR to I.F.).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Isabelle Fournier
  • Julien Franck
  • Céline Meriaux
  • Michel Salzet
    • 1
  1. 1.Laboratoire de Neuroimmunologie et Neurochimie Evolutives, FRE CNRS 3249, MALDI Imaging TeamUniversité Lille Nord de FranceVilleneuve d’Ascq CedexFrance

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