Advances in the Diagnosis and Management of Central Venous Access Device Infections in Children

  • Asha Bowen
  • Jonathan CarapetisEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 697)


Infection is a well-known complication of central venous access device (CVAD) use, with an incidence of 3–6 bloodstream infections per 1,000 catheter days in children. Prevention of CVAD infections has improved with new strategies including the use of chlorhexidine antisepsis, bundles, maximal sterile barriers for insertion, prophylactic locks, antibiotic impregnated catheters and tunnelling of long-term devices. Despite these strategies, catheter-related bloodstream infections (CRBSIs) continue to be an important health problem. New approaches to diagnosis include differential time to positivity and quantification of blood cultures and molecular diagnostics. The management of CRBSIs includes techniques for line salvage including ethanol, antibiotic, hydrochloric acid, taurolidine and urokinase locks. When these fail, line removal and antimicrobial therapy are recommended.


Paediatric Intensive Care Unit Bloodstream Infection Central Venous Access Device Intravascular Device Peripheral Blood Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Paediatric Infectious DiseasesAlice Springs HospitalAlice SpringsAustralia
  2. 2.Menzies School of Health ResearchDarwinAustralia
  3. 3.Charles Darwin UniversityDarwinAustralia

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