Human Herpesvirus 6

  • Charles G. ProberEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 697)


Human herpesvirus 6 (HHV-6) is a member of the family Herpesviridae. This family of eight viruses includes four Alphaherpesvirinae (herpes simplex virus type 1 [HSV-1], herpes simplex virus type 2 [HSV-2], human herpesvirus 8 [HHV-8], and varicella-zoster virus [VZV]); one Gammaherpesvirinae (Epstein–Barr virus [EBV]); and three Betaherpesvirinae (cytomegalovirus [CMV], HHV-6, and human herpesvirus 7 [HHV-7]) [1]. Common physical traits of these clinically important DNA viruses include large size (150–200 nm), an icosahedral nucleocapsid encased in an envelope that has multiple surface projections, and a large number of structural proteins. Their genomes are linear and double-stranded, varying in size from 120 to 230 kb and specifying a large number of enzymes involved in nucleic acid metabolism. The intranuclear replication of herpesviruses is complex and destruction of the infected cells accompanies the production of progeny.


Herpes Simplex Virus Type Primary Infection Febrile Seizure Human Herpesvirus Solid Organ Transplant Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Prober CG. Introduction to Herpesviridae. Chapter 203. In: Long SS, Pickering LJ, Prober CG, editors. Principles and practice of pediatric infectious diseases. 3rd ed. Philadelphia, PA: Elsevier; 2008.Google Scholar
  2. 2.
    Prober CG. Sixth disease and the ubiquity of human herpesviruses. N Engl J Med. 2005;352:753–55.CrossRefPubMedGoogle Scholar
  3. 3.
    Salahuddin S, Ablashi D, Markham P et al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986;234:596–601.CrossRefPubMedGoogle Scholar
  4. 4.
    Yamanishi K, Okuno T, Shiraki K et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988;1:1065–67.CrossRefPubMedGoogle Scholar
  5. 5.
    Zerr D, Meier A, Selke S et al. A population-based study of primary human herpesvirus 6 infection. N Engl J Med. 2005;352:768–76.CrossRefPubMedGoogle Scholar
  6. 6.
    Breese Hall C. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum). Chapter 208. In: Long SS, Pickering LJ, Prober CG, editors. Principles and Practice of Pediatric Infectious Diseases. 3rd ed. St Louis, MO: Elsevier; 2008.Google Scholar
  7. 7.
    Hall C, Long C, Schnabel K et al. Human herpesvirus-6 infection in children: a prospective study of complications and reactivation. N Engl J Med. 1994;331:432–38.CrossRefPubMedGoogle Scholar
  8. 8.
    Yao K, Honarmand S, Espinosa A et al. Detection of human herpesvirus-6 in cerebrospinal fluid of patient with encephalitis. Ann Neurol. 2009;65:257–67.CrossRefPubMedGoogle Scholar
  9. 9.
    Katzoli P, Sakellaris G, Ergazaki M et al. Detection of herpes viruses in children with acute appendicitis. J Clin Virol. 2009;44(4):282–86.CrossRefPubMedGoogle Scholar
  10. 10.
    Hennus MP, van Montfrans JM, van Vught AJ et al. Life-threatening human herpes virus-6 infection in early childhood: presenting symptom of a primary immunodeficiency?. Pediatr Crit Care Med. 2009;10(2):e16–e18.CrossRefPubMedGoogle Scholar
  11. 11.
    Comar M, D’Agaro P, Campello C et al. Human herpes virus 6 in archival cardiac tissues from children with idiopathic dilated cardiomyopathy or congenital heart disease. J Clin Pathol. 2009;62(1):80–3.CrossRefPubMedGoogle Scholar
  12. 12.
    Crawford JR, Santi MR, Cornelison R et al. Detection of human herpesvirus-6 in adult central nervous system tumors: predominance of early and late viral antigens in glial tumors. J Neurooncol. 2009;95(1):49–60.CrossRefPubMedGoogle Scholar
  13. 13.
    de Pagter PJ, Schuurman R, Visscher H et al. Human herpesvirus type 6 reactivation after hematopoietic stem cell transplantation. J Clin Virol. 2008;43:361–66.CrossRefPubMedGoogle Scholar
  14. 14.
    Pellett P, Black J. Human herpesvirus 6. In: Fields B, Knipe D, Howley P (eds). Fields’ Virology. 3rd ed. Philadelphia, PA: Lippincott-Raven; 1996. p. 2587–608.Google Scholar
  15. 15.
    Suga A, Yoshikawa T, Asano Y et al. Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. Ann Neurol. 1993;33:597–603.CrossRefPubMedGoogle Scholar
  16. 16.
    Luppi M, Barozzi P, Maiorana A et al. Human herpesvirus-6: a survey of presence and distribution of genomic sequences in normal brain and neuroglial tumors. J Med Virol. 1995;47:105–11.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Pediatrics, Microbiology and Immunology, Medical EducationStanford School of Medicine, Stanford University Medical CenterStanfordUSA

Personalised recommendations