Human Herpesvirus 6
Human herpesvirus 6 (HHV-6) is a member of the family Herpesviridae. This family of eight viruses includes four Alphaherpesvirinae (herpes simplex virus type 1 [HSV-1], herpes simplex virus type 2 [HSV-2], human herpesvirus 8 [HHV-8], and varicella-zoster virus [VZV]); one Gammaherpesvirinae (Epstein–Barr virus [EBV]); and three Betaherpesvirinae (cytomegalovirus [CMV], HHV-6, and human herpesvirus 7 [HHV-7]) . Common physical traits of these clinically important DNA viruses include large size (150–200 nm), an icosahedral nucleocapsid encased in an envelope that has multiple surface projections, and a large number of structural proteins. Their genomes are linear and double-stranded, varying in size from 120 to 230 kb and specifying a large number of enzymes involved in nucleic acid metabolism. The intranuclear replication of herpesviruses is complex and destruction of the infected cells accompanies the production of progeny.
KeywordsHerpes Simplex Virus Type Primary Infection Febrile Seizure Human Herpesvirus Solid Organ Transplant Recipient
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