Prevention of Vertical Transmission of HIV in Resource-Limited Countries

  • Catherine M. WilfertEmail author
  • Tabitha Sripipatana
  • Allison Spensley
  • Mary Pat Kieffer
  • Edward Bitarakwate
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 697)


Prevention of vertical (i.e., mother-to-child) transmission of HIV is essential to reduce significant HIV-related child morbidity and mortality in developing countries. Globally, pediatric infections comprise about 15% of all new HIV infections each year and virtually all pediatric infections can be prevented by eliminating vertical transmission [1]. The World Health Organization (WHO) recommendations (revised in 2006) for prevention of mother-to-child transmission (PMTCT)1 include a four-pronged comprehensive strategy [2]. Although we acknowledge the critical role that all approaches play in reducing pediatric HIV infection, the focus of this chapter is on strategies that address the third prong: preventing HIV transmission from infected mothers to their infants. Considerable achievements have been made on this front, including many clinical trials demonstrating good efficacy.


Exclusive Breastfeed Vertical Transmission PMTCT Program PMTCT Service Vertical Transmission Rate 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Catherine M. Wilfert
    • 1
    Email author
  • Tabitha Sripipatana
    • 1
  • Allison Spensley
    • 1
  • Mary Pat Kieffer
    • 1
  • Edward Bitarakwate
    • 1
  1. 1.Elizabeth Glaser Pediatric AIDS FoundationLos AngelesUSA

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