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Neonatal Herpes Simplex Virus Infections: Where Are We Now?

  • Clara Thompson
  • Richard WhitleyEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 697)

Abstract

Neonatal herpes simplex virus (HSV) infection continues to cause significant morbidity and mortality despite advances in diagnosis and treatment. Prior to antiviral therapy, 85% of patients with disseminated HSV disease and 50% of patients with central nervous system disease died within 1 year. The advent of antiviral therapy has dramatically improved the prognosis of neonatal HSV with initially vidarabine and subsequently acyclovir increasing the survival rate of infected neonates and improving long-term developmental outcomes. More recently, polymerase chain reaction has allowed earlier identification of HSV infection and provided a quantitative guide to treatment. Current advances in the treatment of neonatal HSV infections are looking toward the role of prolonged oral suppression therapy in reducing the incidence of recurrent disease. Of concern, however, are increasing reports of acyclovir-resistant HSV isolates in patients following prolonged therapy.

Keywords

Herpes Simplex Virus Central Nervous System Disease Herpes Simplex Virus Infection Herpes Simplex Virus Encephalitis Neonatal Herpes Simplex Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.PaediatricsJohn Radcliffe Children’s HospitalOxfordUK
  2. 2.Paediatrics, Microbiology, Medicine and NeurosurgeryThe University of AlabamaBirminghamUSA

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