Development and Analysis of Models of Genetic and Metabolic Networks and Signal Transduction Pathways in the GeneNet System

Abstract

The GeneNet system was designed to construct and analyze information models of complex molecular genetic systems. The GeneNet system allows manifold data on the structure—function organization of gene and metabolic networks and signal transduction pathways to be accumulated in the context of a unified approach and to be visualized as interactive graphs. The GeneNet data are used to model the network dynamics and search for optimal means for control and correction of gene network behavior. The GeneNet system now contains descriptions of 37 gene networks regulating various functions of organisms. The information stored in the system was collected by annotating experimental publications. The academic version of GeneNet is available at http:// wwwmgs.bionet.nsc.ru/mgs/gnw/genenetworks.shtml.