Latent Periodicity of Many Domains in Protein Sequences Reflects Their Structure, Function, and Evolution
We have analyzed many protein sequences for the presence of latent periodicity common for their functionally identical sites. As a result, we found that Rossman-like domains of TPP-binding enzymes, ATP synthases, and pyridoxal phosphate-dependent enzymes as well as many other α/β-proteins, such as dethiobiotin synthases, have latently periodic structure. We also identified the periodicity pattern responsible for formation of parallel n-barrel in a number of enzymes. Possible relationships of regular structures and latent periodicity are also discussed.
Key wordsperiodicity repeats profile analysis Rossman-like domains regular structures molecular evolution duplication structure-function relationship
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