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Cardiac Cell Therapy: Present and Future

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Abstract

End stage heart failure following myocardial infarction is a major health problem despite significant improvement in treatment intervention. Heart transplantation is the only option to treat end stage heart failure patients, however; the supply needed has severe shortage. Therefore, cell transplantation has gained significant interest as a future treatment of various heart diseases including myocardial infarction. Optimal cell type for complete cardiac regeneration is still needed as clinical trials using adult stem cell transplantation so far did not show long-term significant improvement in cardiac function. Moreover, there are concerns over the differentiation of adult stem cells into cardiac cell types. Embryonic stem cells can be used for cell transplantation but their potential in clinical trial has been hampered due to their characteristics of teratoma formation. Furthermore, beneficial effects observed in clinical and experimental studies that may be associated with released autocrine or paracrine factors following cell transplantation is another major area of current investigation discussed in this review.

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Authors and Affiliations

  1. Biomolecular Science Center, University of Central Florida, Orlando, FL, USA

    Dinender K. Singla

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  1. Dinender K. Singla
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Correspondence to Dinender K. Singla .

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Editors and Affiliations

  1. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

  2. Jikei University School of Medicine, Shibuya-ku, Ebisu 3-31-6, Tokyo, 150-0013, Japan

    Makoto Nagano

  3. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

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Singla, D.K. (2011). Cardiac Cell Therapy: Present and Future. In: Dhalla, N., Nagano, M., Ostadal, B. (eds) Molecular Defects in Cardiovascular Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7130-2_7

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  • DOI: https://doi.org/10.1007/978-1-4419-7130-2_7

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