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Modulators of Remodeling After Myocardial Infarction

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Molecular Defects in Cardiovascular Disease

Abstract

Remodeling of the heart wounded by myocardial infarction (MI) refers to the sum total of adaptive and maladaptive changes in myocardial structure, geometric shape, and function that occur over time after the initial event. Its consequences are most sinister in the patient with a large anterior transmural MI, also clinically known as the ST-segment MI (STEMI) in the early hours or Q-wave MI in later stages. It is recognized that these infarcts undergo adverse remodeling that leads to progressive left ventricular (LV) remodeling, which is the central mechanism in the march to ventricular dilatation, ventricular dysfunction, congestive heart failure, disability, and death. Over time, remodeling in survivors extends to other cardiac chambers, tissues, cells, and molecules, resulting in a vicious cycle leading to end-stage heart disease with significant morbidity and mortality. Knowledge of the modulators of the remodeling process is critical in efforts to prevent, interrupt, or limit the progression toward end-stage heart failure or reverse it. The focus of this chapter is on some key modulators of the post-MI remodeling process.

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Acknowledgments

This work was supported in part by grant # IAP99003 from the Canadian Institutes of Health Research, Ottawa, Ontario. I thank Catherine Jugdutt for assistance.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, University of Alberta and Hospitals, Edmonton, Alberta, Canada

    Bodh I. Jugdutt

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  1. Bodh I. Jugdutt
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Correspondence to Bodh I. Jugdutt .

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Editors and Affiliations

  1. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

  2. Jikei University School of Medicine, Shibuya-ku, Ebisu 3-31-6, Tokyo, 150-0013, Japan

    Makoto Nagano

  3. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

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Jugdutt, B.I. (2011). Modulators of Remodeling After Myocardial Infarction. In: Dhalla, N., Nagano, M., Ostadal, B. (eds) Molecular Defects in Cardiovascular Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7130-2_17

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  • DOI: https://doi.org/10.1007/978-1-4419-7130-2_17

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