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Metabolic Remodelling of the Hypertrophied Heart

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Molecular Defects in Cardiovascular Disease

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Abstract

The heart develops hypertrophy in response to persistent elevation in cardiac workload. Depending on the nature of the stimulus, cardiac hypertrophy can be categorized as pathologic or physiologic, each of which is accompanied by distinctly different phenotypic alterations including alterations in energy metabolism. These unique metabolic phenotypes may, in part, explain the differing functional outcomes of pathologically and physiologically hypertrophied hearts, especially notable following an ischemic stress. Thus, the mechanisms underlying remodelling in pathologic and physiologic cardiac hypertrophy have been the focus of many studies. A number of molecules including AMP-activated protein kinase, peroxisome proliferator-activated receptor-α, peroxisome proliferator-activated receptor gamma coactivator 1, protein kinase C, phosphoinositide-3 kinase/protein kinase B, and reactive oxygen species have been implicated as participating in the process of metabolic remodelling in cardiac hypertrophy.

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Acknowledgements

This work was supported by CIHR. We thank Mr. Rich Wambolt and all the current and former members of the Allard laboratory who have contributed to the studies summarized here.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine/Heart and Lung Institute, University of British Columbia, Vancouver, BC, Canada

    Jiazhen M. Dai

  2. Department of Pathology and Laboratory Medicine/James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

    Michael F. Allard

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  1. Jiazhen M. Dai
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  2. Michael F. Allard
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Correspondence to Michael F. Allard .

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Editors and Affiliations

  1. St. Boniface General Hospital, Research Centre, Institute of Cardiovascular Sciences, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Naranjan S. Dhalla

  2. Jikei University School of Medicine, Shibuya-ku, Ebisu 3-31-6, Tokyo, 150-0013, Japan

    Makoto Nagano

  3. Czech Republic, Institute of Physiology, Academy of Sciences of the, Videnska 1083, Prague, 142 20, Czech Republic

    Bohuslav Ostadal

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Dai, J.M., Allard, M.F. (2011). Metabolic Remodelling of the Hypertrophied Heart. In: Dhalla, N., Nagano, M., Ostadal, B. (eds) Molecular Defects in Cardiovascular Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7130-2_10

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