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Zinc and Zinc Transport and Sequestration Proteins in the Brain in the Progression of Alzheimer’s Disease

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Neurochemical Mechanisms in Disease

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 1))

Abstract

Multiple studies over the past 25 years have demonstrated alterations of zinc (Zn) in the brain in Alzheimer’s disease (AD), although the potential fole of these alterations in the pathogenesis of AD remains unclear. The following examines normal and abnormal roles of Zn and Zn transport (ZIP and ZnT) proteins in brain and the potential effects of their alterations in the pathogenesis of AD.

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Acknowledgments

Supported by NIH grants 1R01-AG16269, 5-P01-AG05119, and 1P30-AG028383, and by a grant from the Abercrombie Foundation. The author thanks Ms. Paula Thomason for editorial assistance.

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Authors and Affiliations

  1. Department of Chemistry, Sanders-Brown Center on Aging and Alzheimer’s Disease Center, University of Kentucky, Lexington, KY, 40536, USA

    Mark A. Lovell

  2. Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA

    Mark A. Lovell

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  1. Mark A. Lovell
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Correspondence to Mark A. Lovell .

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  1. Burke Rehabilitation Center, Mamaroneck Ave. 785, White Plains, 10605, New York, USA

    John P. Blass

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Lovell, M.A. (2011). Zinc and Zinc Transport and Sequestration Proteins in the Brain in the Progression of Alzheimer’s Disease. In: Blass, J. (eds) Neurochemical Mechanisms in Disease. Advances in Neurobiology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7104-3_20

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