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Molecular Mechanisms of Neuronal Death

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Book cover Neurochemical Mechanisms in Disease

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 1))

Abstract

Cellular homeostasis, maintenance of the balance of life and death at the cellular level, is essential for tissue integrity from development through senescence. During development of the nervous system programmmed cell death is responsible for establishing the number of neurons and shaping the nervous system. After development the majority of the postmitotic neurons should live for the life of the organism. Aberrant neuronal death occurs in neurodegenerative diseases and there is still no clear understanding of the mechanisms involved. In this chapter we discuss the molecules and pathways that regulate the life and death of cells and illustrate how these pathways are potentially involved in neurodegenerative diseases. By understanding the molecular mechanisms that regulate cell death we can then begin to identify which pathways are dysregulated in neurodegenerative diseases.

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  1. Department of Pathology, Taub Center for the Study of Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA

    Elena M. Ribe, Lianna Heidt & Nike Beaubier

  2. Departments of Pathology and Neurology, Taub Center for the Study of Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, 10032, USA

    Carol M. Troy

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    John P. Blass

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Ribe, E.M., Heidt, L., Beaubier, N., Troy, C.M. (2011). Molecular Mechanisms of Neuronal Death. In: Blass, J. (eds) Neurochemical Mechanisms in Disease. Advances in Neurobiology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7104-3_2

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