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Brain Protein Oxidation and Modification for Good or for Bad in Alzheimer’s Disease

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Book cover Neurochemical Mechanisms in Disease

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 1))

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and is characterized by senile plaques, neurofibrillary tangles, synapse loss, and progressive neuronal deficits. There is an abundance of evidence suggesting that oxidative stress is involved in the pathogenesis of Alzheimer’s disease. Several investigations have revealed the presence of oxidation products of proteins, lipids, and DNA in postmortem tissue from AD patients, indices that are indicative of increased oxidative stress. In the present review we discuss the role of protein oxidation in the brain of subjects with AD and MCI.

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Acknowledgments

This work was supported in part by NIH grants [AG-10836; AG-05119].

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Authors and Affiliations

  1. Department of Chemistry, University of Kentucky, Lexington, KY, 40506, USA

    Rukhsana Sultana & D. Allan Butterfield

  2. Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40506, USA

    Rukhsana Sultana & D. Allan Butterfield

  3. Department of Chemistry, Center of Membrane Sciences, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40506, USA

    D. Allan Butterfield

  4. Center of Membrane Sciences, University of Kentucky, Lexington, KY, 40506, USA

    D. Allan Butterfield

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  1. Rukhsana Sultana
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Correspondence to D. Allan Butterfield .

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  1. Burke Rehabilitation Center, Mamaroneck Ave. 785, White Plains, 10605, New York, USA

    John P. Blass

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Sultana, R., Butterfield, D.A. (2011). Brain Protein Oxidation and Modification for Good or for Bad in Alzheimer’s Disease. In: Blass, J. (eds) Neurochemical Mechanisms in Disease. Advances in Neurobiology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7104-3_17

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