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NF-κB in Brain Diseases

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Neurochemical Mechanisms in Disease

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 1))

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Abstract

Nuclear factor κB (NF-κB) is a family of major transcription factors that play various important roles under physiological and pathological conditions. NF-κB transcription factors are ubiquitously expressed, including neurons and glial cells of the central nervous system (CNS). The roles of NF-κB family in the CNS, both as mediators of transcriptional response to synaptic activity and in behavioral paradigms of learning and memory, are the focus of recent studies. In this chapter, the general structure, major functions, and the regulation of NF-κB signaling are first described concisely. Advances made in understanding of the roles of NF-κB in the CNS and in brain diseases are then reviewed in more detail. The NF-κB signaling pathway as a potential therapeutic target of brain diseases is discussed at the end.

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Abbreviations

AD:

Alzheimer disease

CNS:

Central nervous system

HD:

Huntington’s disease

IκB:

Inhibitor of NF-κB

IKK:

IκB kinase

IL:

Interleukin

LTP:

Long-term potentiation

NES:

Nuclear export signal

NF-κB:

Nuclear factor κB

NIK:

NF-κB–inducing kinase

NGF:

Nerve growth factor

PD:

Parkinson’s disease

SOD:

Superoxide dismutase

SRD:

Signal response domain

TNF:

Tumor necrosis factor

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Acknowledgments

The author is grateful to Drs. K. Iqbal and I. Grundke-Iqbal of our institute and Dr. X. Zhu of the Institute of Pathology, Case Western Reserve University, Cleveland, OH, for critical reading of the manuscript, to Ms. M. Marlow of our institute for help in editing this manuscript, and to Ms. J. Murphy and Ms. S. Warren for secretarial assistance. Studies in my laboratory are supported in part by funds from the New York State Office of Mental Retardation and Developmental Disabilities, and grants from the NIH (R01 AG16760, R01 AG027429), the Alzheimer’s Association, Chicago, IL (IIRG-05-13095), and the Li Foundation, Inc., New York, NY.

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  1. Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, 10314-6399, USA

    Cheng-Xin Gong

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  1. Burke Rehabilitation Center, Mamaroneck Ave. 785, White Plains, 10605, New York, USA

    John P. Blass

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Gong, CX. (2011). NF-κB in Brain Diseases. In: Blass, J. (eds) Neurochemical Mechanisms in Disease. Advances in Neurobiology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7104-3_10

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