Introduction to the Hematopoietic Growth Factors

Part of the Cancer Treatment and Research book series (CTAR, volume 157)


The hematopoietic growth factors (HGFs) are an important class of biologic molecules which augment production and functional maturation of hematopoietic cells. As shown in Fig. 1.1, endogenous production of HGFs modulates a wide variety of both hematopoietic and nonhematopoietic cells derived from the myeloid stem cell including progenitor and precursor cells and more functionally mature cells. Clinically, recombinant or mimetic forms of these cytokines are utilized to reduce the severity and duration of hematologic complications resulting from impairment of granulocytopoiesis, erythropoiesis, or thrombopoiesis.


Introduction Hematopoietic Growth Factors 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Duke University and the Duke Comprehensive Cancer CenterDurhamUSA
  2. 2.Department of MedicineUniversity of WashingtonSeattleUSA

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