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Pharmacology and Neurochemistry of Olivocochlear Efferents

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Auditory and Vestibular Efferents

Part of the book series: Springer Handbook of Auditory Research ((SHAR,volume 38))

Abstract

This chapter covers the chemistry and pharmacology of efferent transmission in the cochlea, starting with an overview of the biochemical and biophysical steps following the arrival of an action potential at the peripheral efferent nerve terminal (Sect. 4.1.1). A brief history of advances in understanding the efferent system follows (Sect. 4.1.2). The description of the neurochemistry and pharmacology of efferent action is organized around the sequence of events beginning with the arrival of an action potential at the medial efferent peripheral terminal and ending with the activation of calcium-dependent potassium channels in the outer hair cell (OHC; Sect. 4.2). In Sect. 4.3, other efferent neurotransmitters are covered and, because most of these are associated with the lateral efferent system, it is in this section that much of the knowledge of lateral efferents is presented.

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Acknowledgment

This work was supported by a grant from the NIDCD (R01 DC000767).

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Authors and Affiliations

  1. Department of Otology and Laryngology, Harvard Medical School, Boston, MA, 02114, USA

    William F. Sewell

  2. Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA

    William F. Sewell

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  1. William F. Sewell
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Correspondence to William F. Sewell .

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Editors and Affiliations

  1. Program in Neuroscience, Garvan Institute of Medical Research, 384 Victoria St., Level 7, Darlinghurst, NSW2010, Australia

    David K. Ryugo

  2. Parmly Hearing Institute, Loyola University Chicago, 6525 N. Sheridan Rd., Chicago, 60626, Illinois, USA

    Richard R. Fay

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Sewell, W.F. (2011). Pharmacology and Neurochemistry of Olivocochlear Efferents. In: Ryugo, D., Fay, R. (eds) Auditory and Vestibular Efferents. Springer Handbook of Auditory Research, vol 38. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7070-1_4

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