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Cysteine-String Protein’s Role at Synapses

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Folding for the Synapse

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Abstract

Accumulating evidence illustrates the significance of chaperone systems for the regulation and maintenance of neuronal and synaptic function. The significance of synaptic chaperones is best illustrated by cysteine-string protein (CSP), a member of the DnaJ/Hsp40 family of Hsp70/Hsc70 co-chaperones. CSP recruits the ubiquitous chaperone Hsc70 to synaptic vesicles forming a chaperone complex that maintains synaptic function and prevents neurodegeneration. Here, we summarize studies that demonstrate CSP’s neuroprotective role for synaptic function and ­discuss insights into its possible clientele (the proteins whose function it facilitates).

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Acknowledgements

This work has been supported by grants to K.E.Z. from NINDS (R03 NS057215–01, R21 NS055202–02) and a PERT fellowship to M.I. (K12 GM000708).

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  1. Department of Neuroscience, University of Arizona, 210077, Gould-Simpson Building 627, 1040 E. 4th Street, Tucson, AZ, 85721–0077, USA

    Konrad E. Zinsmaier

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  1. Konrad E. Zinsmaier
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  2. Mays Imad
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Correspondence to Konrad E. Zinsmaier .

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  1. School of Biological Sciences, University of Southampton, Life Science Building (B85), SO17 1BJ, Southampton, SO16 7PX, United Kingdom

    Andreas Wyttenbach

  2. School of Biological Sciences, University of Southampton, Life Science Building (B85), SO17 1BJ, Southampton, SO16 7PX, United Kingdom

    Vincent O'Connor

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Zinsmaier, K.E., Imad, M. (2011). Cysteine-String Protein’s Role at Synapses. In: Wyttenbach, A., O'Connor, V. (eds) Folding for the Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7061-9_8

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