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The Ubiquitin–Proteasome System in Synapses

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Folding for the Synapse

Abstract

The ubiquitin–proteasome system (UPS) is responsible for clearing most soluble proteins in the cytoplasm and nucleus. Recent studies reveal that the UPS function is critical for maintaining synaptic plasticity and transmission and that the UPS dysfunction is associated with axonal degeneration and impaired synaptic transmission. In this chapter, we will focus on the role of the UPS in synapses and the association of UPS impairment with neurological disorders. Since protein misfolding causes several neurological disorders that show synaptic dysfunction during the early stages of disease, understanding the involvement of the synaptic UPS in neurological disorders may help determine effective strategies for treating neurological disorders caused by the accumulation of misfolded proteins.

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Authors and Affiliations

  1. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA

    Xiao-Jiang Li

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  1. Suzanne Tydlacka
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  2. Shi-Hua Li
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Correspondence to Xiao-Jiang Li .

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  1. School of Biological Sciences, University of Southampton, Life Science Building (B85), SO17 1BJ, Southampton, SO16 7PX, United Kingdom

    Andreas Wyttenbach

  2. School of Biological Sciences, University of Southampton, Life Science Building (B85), SO17 1BJ, Southampton, SO16 7PX, United Kingdom

    Vincent O'Connor

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Tydlacka, S., Li, SH., Li, XJ. (2011). The Ubiquitin–Proteasome System in Synapses. In: Wyttenbach, A., O'Connor, V. (eds) Folding for the Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7061-9_10

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