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Nuclear Architecture in Stem Cells

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The Cell Biology of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 695))

Abstract

Fundamental features of genome regulation depend on the linear DNA sequence, cell type specific modification of DNA and chromatin-associated proteins, which locally control the expression of single genes. Architectural features of genome organization within the three-dimensional (3D) nuclear space establish preferential positioning of genes relative to nuclear subcompartments associated with specific biochemical activities, thereby influencing states of expression. The structural and temporal organization of the genome within the nucleus of stem cells, together with specific features of epigenetic and transcriptional regulation are emerging as key players that influence pluripotency and differentiation.1,2

Both authors contributed equally to this work.

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Authors and Affiliations

  1. Genome Function Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK

    Kelly J. Morris, Mita Chotalia & Ana Pombo

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  1. Kelly J. Morris
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  2. Mita Chotalia
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  3. Ana Pombo
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Correspondence to Ana Pombo .

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Editors and Affiliations

  1. Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

    Eran Meshorer PhD

  2. Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California, USA

    Kathrin Plath PhD

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Morris, K.J., Chotalia, M., Pombo, A. (2010). Nuclear Architecture in Stem Cells. In: Meshorer, E., Plath, K. (eds) The Cell Biology of Stem Cells. Advances in Experimental Medicine and Biology, vol 695. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7037-4_2

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