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Proteasome Function Determines Cellular Homeostasis and the Rate of Aging

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Book cover Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

Abstract

Homeostasis is a key feature of cellular lifespan. Maintenance of cellular homeostasis influences the rate of aging and its efficiency is determined by the cooperation between protein stability and resistance to stress, protein refolding, protein repair and proteolysis of damaged proteins. Protein degradation is predominately catalyzed by the proteasome which is responsible for cell clearance of abnormal, denatured or in general damaged proteins as well as for the regulated degradation of short-lived proteins. Impaired proteasome function has been tightly correlated to aging both in vivo and in vitro and thus, emphasis has been given recently in identifying ways of its activation. A number of studies have shown that the proteasome can be activated by genetic manipulations as well as by factors that affect either its conformation and stability or the expression of its subunits and the rate of proteasome assembly. This “readjustment” has been shown to have a great impact on retention of cellular homeostasis since it promotes lifespan extension. This chapter focuses on protein homeostasis and its direct link to proteasome function, dysfunction and manipulation and provides insights regarding the activation of proteasome-mediated protein degradation that, in turn, ensures health maintenance.

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Authors and Affiliations

  1. National Hellenic Research Foundation, 48 Vas. Constantinou Ave., Athens, 11635, Greece

    Niki Chondrogianni & Efstathios S. Gonos

Authors
  1. Niki Chondrogianni
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  2. Efstathios S. Gonos
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Correspondence to Efstathios S. Gonos .

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Nektarios Tavernarakis PhD

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Chondrogianni, N., Gonos, E.S. (2010). Proteasome Function Determines Cellular Homeostasis and the Rate of Aging. In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_4

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