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Synthesis, Modification and Turnover of Proteins during Aging

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Protein Metabolism and Homeostasis in Aging

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 694))

Abstract

Alterations in the rate and extent of protein synthesis, accuracy, post-translational modifications and turnover are among the main molecular characteristics of aging. A decline in the cellular capacity through proteasomal and lysosomal pathways to recognize and preferentially degrade damaged proteins leads to the accumulation of abnormal proteins during aging. The consequent increase in molecular heterogeneity and impaired functioning of proteins is the basis of several age-related pathologies, such as cataracts, sarcopenia and neurodegerative diseases. Understanding the proteomic spectrum and its functional implications during aging can facilitate developing effective means of intervention, prevention and therapy of aging and age-related diseases.

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  1. Laboratory of Cellular Aging, Department of Molecular Biology, Aarhus University, DK8000, Aarhus-C, Denmark

    Suresh I. S. Rattan

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  1. Institute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Nektarios Tavernarakis PhD

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Rattan, S.I.S. (2010). Synthesis, Modification and Turnover of Proteins during Aging. In: Tavernarakis, N. (eds) Protein Metabolism and Homeostasis in Aging. Advances in Experimental Medicine and Biology, vol 694. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7002-2_1

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