Abstract
Small lymphocytes measure <12 μm in diameter, equivalent to the size of a histiocyte nucleus, a segmented neutrophil, or 1.5 to 2 times the size of an erythrocyte. The presence of a monotonous proliferation of small lymphoid cells in an enlarged round and rubbery lymph node is abnormal, and the cytologic findings should be correlated with the clinical scenario. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and the resolving or quiescent phase of a reactive lymphoid hyperplasia are the main and most common entities considered in the differential diagnosis and must be distinguished from other neoplastic and non-neoplastic processes. The following is a list of entities showing the monotonous small-cell pattern. The cytologic description is based on Romanovsky-stained, air-dried smears. We use the WHO classification and nomenclature for lymphoid neoplasms unless otherwise is noted.
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Bonato M, Pittaluga S et al (1998) Lymph node histology in typical and atypical chronic lymphocytic leukemia. Am J Surg Pathol 22(1):49–56
Caraway N P, Thomas E et al (2008) Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival. Cancer 114(5):315–322
Deschenes M, Michel RP et al (2008) Fine-needle aspiration cytology of Castleman disease: case report with review of the literature. Diagn Cytopathol 36(12):904–908
Diehl V, Sextro M et al (1999) Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin’s disease and lymphocyte-rich classical Hodgkin’s disease: report from the European Task Force on Lymphoma Project on Lymphocyte-Predominant Hodgkin’s Disease. J Clin Oncol 17(3):776–783
Dong HY, Harris NL et al (2001) Fine-needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: a retrospective analysis of the utility of cytomorphology and flow cytometry. Mod Pathol 14(5):472–481
Fan Z, Natkunam Y et al (2003) Characterization of variant patterns of nodular lymphocyte predominant hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 27(10):1346–1356
Harris NL, Jaffe ES et al (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 17(12):3835–3849
Hoyer JD, Ross CW et al (1995) True T-cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases. Blood 86(3):1163–1169
Kardos TF, Vinson JH et al (1986) Hodgkins disease: diagnosis by fine-needle aspiration biopsy. Analysis of cytologic criteria from a selected series. Am J Clin Pathol 86(3):286–291
Keller AR, Hochholzer L et al (1972) Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer 29(3):670–683
Koo CH, Rappaport H et al (1989) Imprint cytology of non-Hodgkin’s lymphomas based on a study of 212 immunologically characterized cases: correlation of touch imprints with tissue sections. Hum Pathol 20(12 Suppl 1):1–137
Lim MS, Beaty M et al (2002) T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. Am J Surg Pathol 26(11):1458–1466
Lin P, Bueso-Ramos C et al (2003) Waldenstrom macroglobulinemia involving extramedullary sites: morphologic and immunophenotypic findings in 44 patients. Am J Surg Pathol 27(8):1104–1113
Meyer L, Gibbons D et al (1999) Fine-needle aspiration findings in Castleman’s disease. Diagn Cytopathol 21(1):57–60
Morton LM, Wang SS et al (2006) Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood 107(1):265–276
Shin HJ, Caraway NP et al (2003) Cytomorphologic spectrum of small lymphocytic lymphoma in patients with an accelerated clinical course. Cancer 99(5):293–300
Stani J (1987) Cytologic diagnosis of reactive lymphadenopathy in fine needle aspiration biopsy specimens. Acta Cytol 31(1):8–13
Stewart CJ, Duncan JA et al (1998) Fine needle aspiration cytology diagnosis of malignant lymphoma and reactive lymphoid hyperplasia. J Clin Pathol 51(3):197–203
Tani E, Johansson B et al (1998) T-cell-rich B-cell lymphoma: fine-needle aspiration cytology and immunocytochemistry. Diagn Cytopathol 18(1):1–4
Tong TR, Lee KC et al (2002) T-cell/histiocyte-rich diffuse large B-cell lymphoma. Report of a case diagnosed by fine needle aspiration biopsy with immunohistochemical and molecular pathologic correlation. Acta Cytol 46(5):893–898
Zhang JR, Raza AS et al (2006) Fine-needle aspiration diagnosis of Hodgkin lymphoma using current WHO classification – re-evaluation of cases from 1999–2004 with new proposals. Diagn Cytopathol 34(6):397–402
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Pambuccian, S.E., Bardales, R.H. (2011). The Monotonous Small-Cell Pattern. In: Lymph Node Cytopathology. Essentials in Cytopathology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6964-4_8
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DOI: https://doi.org/10.1007/978-1-4419-6964-4_8
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