BetaSys pp 489-503 | Cite as

Whole-Body and Cellular Models of Glucose-Stimulated Insulin Secretion

  • Gianna Maria Toffolo
  • Morten Gram Pedersen
  • Claudio Cobelli
Chapter
Part of the Systems Biology book series (SYSTBIOL, volume 2)

Abstract

Models of glucose-stimulated insulin secretion are commonly used to measure β-cell function and to gain insight into the biological mechanisms of insulin release. Depending on the scope, the complexity of the model must be chosen appropriately. We present two models of minimal complexity, able to assess β-cell function in an individual during intravenous and oral glucose perturbations, and a comprehensive model of insulin secretion, describing intracellular events. We show how comparison of cellular and minimal models provides insight into the mechanisms underlying the different aspects of the minimal models and yields biological meaning to their indices.

Keywords

β-cell Insulin secretion Glucose control Mathematical models 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Gianna Maria Toffolo
    • 1
  • Morten Gram Pedersen
    • 2
  • Claudio Cobelli
    • 1
  1. 1.Department of Information EngineeringUniversity of PadovaPadovaItaly
  2. 2.Lund University Diabetes CentreMalmöSweden

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