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Bayesian Clinical Trials

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Frontiers of Statistical Decision Making and Bayesian Analysis

Abstract

Innovative clinical trial design is one of the currently most exciting and high impact frontiers in a Bayesian analysis. The increasingly complex nature of clinical study designs and the increasing pressures for efficient and ethical design naturally lead to Bayesian approaches. In this chapter we discuss some examples of specific research problems, including adaptive and sequential trial design, sample size choice determination for longitudinal studies, and subgroup analysis.

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Author information

Authors and Affiliations

  1. Department of Statistics, University of Connecticut, 215 Glenbrook Road, U-4120, Storrs, CT, 06269, USA

    Prof. Ming-Hui Chen & Prof. Dipak K. Dey

  2. Department of Biostatistics, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 447, Houston, TX, 77030, USA

    Prof. Peter Müller

  3. Department of Statistics, University of Missouri-Columbia, 146 Middlebush Hall, Columbia, MO, 65211, USA

    Prof. Dongchu Sun

  4. Department of Management Science and Statistics, College of Business, University of Texas at San Antonio, San Antonio, TX, 78249, USA

    Prof. Keying Ye

Authors
  1. Prof. Ming-Hui Chen
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  2. Prof. Dipak K. Dey
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  3. Prof. Peter Müller
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  4. Prof. Dongchu Sun
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  5. Prof. Keying Ye
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Corresponding author

Correspondence to Ming-Hui Chen .

Editor information

Editors and Affiliations

  1. Dept. Statistics, University of Connecticut, Glenbrook Road 215, Storrs, 06269-4120, USA

    Ming-Hui Chen

  2. The University of Texas M. D. Anderson C, Pressler St. 1400, Houston, 77030, USA

    Peter Müller

  3. University of Missouri-Columbia, 146 Middlebush Hall, Columbia, 65211, USA

    Dongchu Sun

  4. University of Texas at San Antonio, San Antonio, 78249, USA

    Keying Ye

  5. University of Connecticut, 215 Glenbrook Road, Storrs, 06269-4120, USA

    Dipak K. Dey

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© 2010 Springer New York

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Chen, MH., Dey, D.K., Müller, P., Sun, D., Ye, K. (2010). Bayesian Clinical Trials. In: Chen, MH., Müller, P., Sun, D., Ye, K., Dey, D. (eds) Frontiers of Statistical Decision Making and Bayesian Analysis. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6944-6_8

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