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Mast Cell and Bladder Pain Syndrome

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Bladder Pain Syndrome

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Abstract

It is likely that Bladder Pain Syndrome (BPS) has a multifactorial etiology that may act predominantly through one or more pathways resulting in the typical symptom complex. There are an abundance of theories regarding the pathogenesis. Among the numerous proposals are “leaky epithelium,” mast cell activation, and neurogenic inflammation. Current evidence from clinical and laboratory studies confirms that mast cells play a central role in the pathogenesis and pathophysiology of BPS, at least in a subgroup of the patients. An increased number of activated mast cells in the bladder lining including in the detrusor muscle are thought to play an important role in pathophysiology of BPS. Upon activation mast cells release biologically active mediators that may cause the symptoms of BPS. In this chapter, we focus on the role of mast cells in BPS, and current available information is provided.

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Authors and Affiliations

  1. Smooth Muscle Research Center, Department of Clinical Biochemistry, Koege Hospital, University of Copenhagen, Lykkebaekvej 1, DK-4600, Koege, Denmark

    Kirsten Bouchelouche M.D., D.M.Sc. & Pierre Bouchelouche M.D.

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  1. Kirsten Bouchelouche M.D., D.M.Sc.
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  2. Pierre Bouchelouche M.D.
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Correspondence to Kirsten Bouchelouche M.D., D.M.Sc. .

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Editors and Affiliations

  1. University of Copenhagen, Department of Urology, Herlev Hospital, Herlev, 2730, Denmark

    Jørgen Nordling

  2. University Hospital Antwerp, Department of Urology, and Antwerp University, Edegem, 2650, Belgium

    Jean Jacques Wyndaele

  3. and Internal Medicine, Erasmus MC,, Departments of Immunology, University Medical Center Rotterdam, Rotterdam, 3141 XW, Netherlands

    Joop P. van de Merwe

  4. Koege Hospital, Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, 4600, Denmark

    Pierre Bouchelouche

  5. Department Obstetrics and Gynecology, Department of Urogynecology S.Carlo-IDI, Catholic University, Rome, 00165, Italy

    Mauro Cervigni

  6. Institute of Clinical Sciences, Department of Urology, Sahlgrens Academy at University of Gothenburg, Göteborg, 41345, Sweden

    Magnus Fall

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Bouchelouche, K., Bouchelouche, P. (2013). Mast Cell and Bladder Pain Syndrome. In: Nordling, J., Wyndaele, J., van de Merwe, J., Bouchelouche, P., Cervigni, M., Fall, M. (eds) Bladder Pain Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6929-3_5

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