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Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents

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Neuropeptide Systems as Targets for Parasite and Pest Control

Part of the book series: Advances in Experimental Medicine and Biology ((volume 692))

Abstract

Various insect species have a severe impact on human welfare and environment and thus force us to continuously develop novel agents for pest control. Neuropeptides constitute a very versatile class of bioactive messenger molecules that initiate and/or regulate a wide array of vital biological processes in insects by acting on their respective receptors in the plasmamembrane of target cells. These receptors belong to two distinct categories of signal transducing proteins, i.e., heptahelical or G protein-coupled receptors (7TM, GPCR) and single transmembrane containing receptors. An increasing amount of evidence indicates that insect neuropeptide-receptor couples play crucial roles in processes as diverse as development, metabolism, ecdysis and reproduction. As such, they gain growing interest as promising candidate targets for the development of a new generation of species- and receptor-specific insect control agents that may generate fewer side effects. In this chapter, we will present some examples of insect neuropeptide receptors and aim to demonstrate their fundamental importance in insect biology.

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Authors and Affiliations

  1. Research Unit Functional Genomics and Proteomics, Zoological Institute, Katholieke Universitet Leuven, Leuven, Belgium

    Matthias B. Van Hiel, Tom Van Loy, Jeroen Poels, Hans Peter Vandersmissen, Heleen Verlinden, Liesbeth Badisco & Jozef Vanden Broeck

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  1. Matthias B. Van Hiel
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  2. Tom Van Loy
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  3. Jeroen Poels
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  5. Heleen Verlinden
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  7. Jozef Vanden Broeck
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Correspondence to Jozef Vanden Broeck .

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  1. Institute of Parasitology, McGill University, Montréal, Québec, Canada

    Timothy G. Geary PhD

  2. Parasitology, School of Biological Sciences, Medical Biology Centre, Queen’s University Belfast, Belfast, UK

    Aaron G. Maule PhD

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Van Hiel, M.B. et al. (2010). Neuropeptide Receptors as Possible Targets for Development of Insect Pest Control Agents. In: Geary, T.G., Maule, A.G. (eds) Neuropeptide Systems as Targets for Parasite and Pest Control. Advances in Experimental Medicine and Biology, vol 692. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6902-6_11

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