Abstract
Infectious disease outbreak detection is one of the main objectives of syndromic surveillance systems. Accurate and timely detection can provide valuable information for public health officials to react to major public health threats. However, disease outbreaks are often not directly observable. Moreover, additional noise caused by routine behavioral patterns and special events further complicates the task of identifying abnormal patterns caused by infectious disease outbreaks. We consider the problem of identifying outbreak patterns in a syndrome count time series using the Markov switching models. The outbreak states are treated as hidden (unobservable) state variables. Gibbs sampler then is used to estimate both the parameters and hidden state variables. We cover both the theoretical foundation of the estimation methods and the technical details of estimating the Markov switching models. A case study is presented in the last section.
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Suggested Reading
Kim, C.-J., Nelson, C.R., 1999. State-Space Models with Regime Switching. MIT Press, Cambridge, MA. 297 pages.
This book covers important topics of state-space models in general and Markov switching models in specific. Both classical estimation methods and Gibbs sampler are discussed in detail. The authors also provide sample programs that implement the algorithms discussed in the book.
Online Resources
The R Project provides a cross-platform computational environment that is suitable to implement the Markov switching models. The project website can be found at http://www.r-project.org/
The BioPortal project’s homepage is at http://bioportal.eller.arizona.edu
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Lu, HM., Zeng, D., Chen, H. (2011). Markov Switching Models for Outbreak Detection. In: Castillo-Chavez, C., Chen, H., Lober, W., Thurmond, M., Zeng, D. (eds) Infectious Disease Informatics and Biosurveillance. Integrated Series in Information Systems, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6892-0_6
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DOI: https://doi.org/10.1007/978-1-4419-6892-0_6
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